Photoaging and Cosmetic Result with Artificial Daylight Photo dynamic Therapy Using Methyl Aminolevulinate

Q: What was the main objective of the ArtLight study?

To gain comprehensive insights into the cosmetic effect of methyl aminolevulinate-artificial daylight photodynamic therapy for patients with actinic keratoses using different artificial daylight systems under real-world conditions.

Q: How were cosmetic effects and photoaging changes assessed?

Cosmetic effects were evaluated using photoaging parameters including global photoaging score, mottled pigmentation, tactile roughness, telangiectasias, and fine lines, each recorded on a 5-point scale (0–4).

Q: What did the study find about photoaging improvements after treatment?

At month 3, all five photoaging parameters were significantly reduced from baseline (p < 0.001), and most patients and investigators rated the cosmetic result as good or very good.

Sep 23, 2026

Uploaded by Connor

Artificial daylight photodynamic therapy using methyl aminolevulinate is evaluated as an effective, nearly painless option for actinic keratoses. The prospective, non-interventional multicentre ArtLight study (NCT05725213) assessed the cosmetic outcome in real-world conditions with different artificial daylight systems. Patients with Olsen grade 1–2 actinic keratoses on the face and scalp in Germany received methyl aminolevulinate-artificial daylight photodynamic therapy, and photoaging parameters were measured on a 0–4 scale.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages7

Reading Time18 min

AccessFree to download

Background

Ultraviolet exposure and photodamage

Cosmetic impact and treatment rationale

Study Design and Methods

ArtLight study overview and objectives

Treatment and patient population

Photoaging assessment parameters

Results

Reduction of photodamage parameters at month 3

Patient and investigator ratings

Conclusions

Cosmetic benefits beyond lesion eradication

1/7 ORIGINAL REPORT Photoaging and Cosmetic Result with Artificial Daylight Photo dynamic Therapy Using Methyl Aminolevulinate Rolf-Markus SZEIMIES1, Matthias BRÜCKNER2, Matthias HOFFMANN3, Melvin BAÉ4, Jörg FRÄNKEN5, Bernd GROßMANN6, Uwe PAASCH7, Sven QUIST8, Berenice M. LANG 9, Rajeev CHAVDA10 and Wolfgang G. PHILIPP-DORMSTON11,12 1Knappschaft Kliniken Recklinghausen, Recklinghausen, Germany, 2Galderma Laboratorium GmbH, Düsseldorf, Germany, 3Hautarztpraxis Dr. Hoffmann, Witten, Germany,4 Privatpraxis Dermatologie am Luisenplatz, Potsdam, Germany, [5](5 Dermatologische Praxis Dr. med. Fr)[ Dermatologische Praxis Dr. med. Fr](5 Dermatologische Praxis Dr. med. Fr)änken, Schwelm, Germany, 6 MVZ Fokus-Haut Corius Koblenz, Koblenz, Germany, 7 Hautarztpraxis [Hautaerzte-paasch.de](Hautaerzte-paasch.de), Jesewitz OT Gotha, Germany, 8BAG Drs. Quist, Mainz, Germany, 9Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Frankfurt, Frankfurt am Main, Germany, 10Galderma SA, Switzerland, 11Hautzentrum Köln (Cologne Dermatology), Köln, Germany, and 12Faculty of Health, University Witten-Herdecke, Witten, Germany Artificial daylight photodynamic therapy with methyl aminolevulinate is an effective and almost painless treatment approach for actinic keratoses. The objective of the prospective, non-interventional, multicentre study ArtLight (NCT05725213) was to gain comprehensive insights into the cosmetic effect of methyl aminolevulinate-artificial daylight photodynamic therapy in patients with actinic keratoses using different artificial daylight systems under real-world conditions. The study enrolled patients with Olsen grade 1 or 2 actinic keratoses on the face and scalp in Germany. Patients were treated with methyl aminolevulinateartificial daylight photodynamic therapy. The cosmetic effect was assessed via photodamage parameters (global score for photoaging, mottled pigmentation, tactile roughness, telangiectasias, fine lines) . Each photodamage variable was recorded on a 5-point scale (0–4) . In total, 224 patients (median age: 75.0 years [range 50–91], 85.3% male, 62.5% Olsen grade 2, 55.4% treatment-naive) were treated with methyl aminolevulinate-artificial daylight photodynamic therapy. At month 3, all 5 parameters of photoaging were significantly reduced from baseline (p < 0.001) . The majority of patients (81.3%) and investigators (83.6%) rated the cosmetic result as good or very good. Beyond effective eradication of actinic keratoses, field-directed methyl aminolevulinate-artificial daylight photodynamic therapy can improve photoaging symptoms, including tactile roughness, mottled pigmentation, telangiectasis, and fine lines. Thus methyl aminolevulinate-artificial daylight photodynamic therapy provides additional benefits, particularly for patients concerned with cosmetic outcomes during or after treatment. Key words: actinic keratosis; methyl aminolevulinate; photoaging of skin; photodynamic therapy; telangiectasia. Submitted Feb 24, 2025. Accepted after revision Mar 28, 2025 Published Apr 22, 2025. DOI: 10.2340/actadv.v105.43245 Acta Derm Venereol 2025; 105: adv43245 . Corr: [Prof. Dr. med. Rolf-Markus Szeimies](Prof. Dr. med. Rolf-Markus Szeimies), Knappschaft Kliniken Reckling hausen, Dorstener Str. 151, DE-45657 Recklinghausen, Germany. E-mail: [Rolf-Markus.Szeimies@knappschaft-kliniken.de](Rolf-Markus.Szeimies@knappschaft-kliniken.de) Actfoilnlcwkeringatoselongs-te(AKrm) are keratinocyte neoplasms exposure to ultraviolet (UV) SIGNIFICANCE Beyond effective eradication of actinic keratoses, fielddirected methyl aminolevulinate-artificial daylight photodynamic therapy can improve photodamage symptoms, including tactile roughness, mottled pigmentation, telangiectasis, and fine lines. Methyl aminolevulinate-artificial daylight photodynamic therapy provides additional benefits, particularly for patients who are concerned with cosmetic outcomes during or after treatment. As the treatme

FAQs

What was the main objective of the ArtLight study?

To gain comprehensive insights into the cosmetic effect of methyl aminolevulinate-artificial daylight photodynamic therapy for patients with actinic keratoses using different artificial daylight systems under real-world conditions.

How were cosmetic effects and photoaging changes assessed?

Cosmetic effects were evaluated using photoaging parameters including global photoaging score, mottled pigmentation, tactile roughness, telangiectasias, and fine lines, each recorded on a 5-point scale (0–4).

What did the study find about photoaging improvements after treatment?

At month 3, all five photoaging parameters were significantly reduced from baseline (p < 0.001), and most patients and investigators rated the cosmetic result as good or very good.

Sep 23, 2026

Uploaded by Connor