Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes

Sep 28, 2026

Uploaded by Aditya

Letter to the editor engaging with an observational study on inflammatory-response-mediated marginal bone loss after dental implant surgery in patients with type 2 diabetes mellitus (T2DM). It highlights clinical relevance for reducing peri-implantitis risk, while noting that complex etiopathogenetic mechanisms linking elevated inflammatory markers to marginal bone loss in T2DM remain insufficiently clarified. It discusses potential covariant roles of perirenal adipose tissue and alcohol consumption and calls for further state-of-the-art bone-assessing research.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages6

Reading Time15 min

AccessFree to download

Letter to the editor

Background and relevance to peri-implantitis risk

Gaps in mechanism explanation

Potential roles of perirenal adipose tissue and alcohol consumption

Need for further research

| W | J | D | World Journal of
Diabetes | | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Diabetes 2025 December 15; 16(12): 114003 DOI: 10.4239/wjd.v16.i12.114003 ISSN 1948-9358 (online) LETTER TO THE EDITOR Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes Jelena S Jadzic, Vladan D Kekovic Specialty type: Endocrinology and metabolism Provenance and peer review: Invited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s classification Scientific Quality: Grade B, Grade C Novelty: Grade B, Grade D Creativity or Innovation: Grade B, Grade D Scientific Significance: Grade B, Grade C P-Reviewer: Wang B, PhD, Professor, China; Xu DJ, MD, Assistant Professor, China Received: September 9, 2025 Revised: October 10, 2025 Accepted: October 27, 2025 Published online: December 15, 2025 Processing time: 97 Days and 17.1 Hours Jelena S Jadzic, Center of Bone Biology, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia Vladan D Kekovic, Department of Maxillofacial Surgery, Faculty of Dental Medicine, University of Belgrade, Belgrade 11000, Serbia Corresponding author: Jelena S Jadzic, MD, PhD, Post Doctoral Researcher, Assistant Professor, Center of Bone Biology, Faculty of Medicine, University of Belgrade, Dr. Subotica 4/2, Belgrade 11000, [Serbia.](Serbia. jelena.jadzic@med.bg.ac.rs)[ jelena.jadzic@med.bg.ac.rs](Serbia. jelena.jadzic@med.bg.ac.rs) Abstract We read with great interest the article by Li et al, reporting an observational study on the inflammatory response-mediated bone loss after dental implant surgery inpatients with type 2 diabetes mellitus (T2DM) . This study provides relevant information for reducing the risk of peri-implantitis after dental implant surgery in T2DM, highlighting the need to bridge the gap between risk identification and effective clinical management. However, the complex etiopathogenetic mechanisms elucidating the association between elevated inflammatory response markers and marginal bone loss in T2DM are not sufficiently clarified. Recent studies suggest that perirenal adipose tissue and alcohol consumption affect bone metabolism, which may contribute to the observed marginal bone loss after dental implant surgery in T2DM. Therefore, further studies using state-of-the-art boneassessing methodologies are needed to enhance our understanding of the potential covariant effects of perirenal adipose tissue and alcohol consumption on inflammatory response-mediated bone loss after dental implant surgery in T2DM. Key Words: Type 2 diabetes mellitus; Dental implants; Inflammatory response; Perirenal adipose tissue; Alcohol consumption ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. WJD [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 15, 2025 Volume 16 Issue 12 Jadzic JS et al. Contributing factors for T2DM-mediated bone loss Core Tip: The observational study by Li et al assessed the inflammatory response after dental implant surgery in patients with type 2 diabetes mellitus (T2DM) . While this study is clinically relevant, the mechanisms elucidating the association between elevated inflammatory markers and marginal bone loss in T2DM are scarcely described. Perirenal adipose tissue secreted adipokines and alcohol consumption may contribute to marginal peri-implant bone alterations in T2DM. Therefore, further studies are needed to assess potential covariant effects of perirenal fat and alcohol consumption on inflammatory responsemediated bone loss after dental implant surgery in patients with T2DM. Citation: Jadzic JS, Kekovic VD. Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes. World J Diabetes 2025; 16(12): 114003 URL: [https://www.wjgne

FAQs

What is the main focus of the letter?

It comments on an observational study examining inflammatory-response-mediated marginal bone loss after dental implant surgery in T2DM and discusses additional factors that may explain the association.

Why does the letter emphasize peri-implantitis risk?

Because the referenced study provides information relevant to reducing peri-implantitis risk in patients with T2DM, linking inflammation after implantation to marginal bone outcomes.

What potential contributors does the letter propose beyond inflammatory markers?

It suggests that perirenal adipose tissue and alcohol consumption may affect bone metabolism and contribute to the marginal bone loss observed after dental implant surgery in T2DM.

Sep 28, 2026

Uploaded by Aditya