Pan-cancer analysis of NUP155 - Pan-cancer analysis, prognosis, immune infiltration

Sep 21, 2026

NUP155 correlates with tumor development, yet its roles in tumor physiology and the tumor immune microenvironment (TIME) had not been previously assessed. This study profiles NUP155 expression, immunological function, and prognostic value across cancer types using bioinformatics and molecular biology. NUP155 is upregulated in 26 cancers and links to advanced stages and poor prognosis, correlating with DNA methylation, tumor mutational burden, microsatellite instability, and stemness. In breast invasive carcinoma, NUP155 promotes oncogenic behavior and is connected with immunomodulatory pathways and immune infiltration.

LanguageEnglish

CategoryResearch & Report

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Pages22

Reading Time55 min

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Abstract

Keywords

Introduction

Cancer burden and immunotherapy

Nuclear pore complex and nucleoproteins

NUP155 background and relevance

Wang et al. BMC Cancer (2024) 24:353 [https://doi.org/10.1186/s12885-024-12039-6](https://doi.org/10.1186/s12885-024-12039-6) BMC Cancer RESEARCH Open Access Pan-cancer analysis of NUP155 and validation of its role in breast cancer cell proliferation, migration, and apoptosis Zi‑qiong Wang1,2,3†, Zhi‑xuan Wu2†, Zong‑pan Wang1, Jing‑xia Bao2, Hao‑dong Wu2, Di‑yan Xu2, Hong‑feng Li2, Yi‑Yin Xu 1, Rong‑xing Wu 1* and Xuan‑xuan Dai 1,2,3* Abstract NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types. Bioinformatics analysis revealed that NUP155 was upregulated in 26 types of cancer. Additionally, NUP155 upregula‑ tion was strongly correlated with advanced pathological or clinical stages and poor prognosis in several cancers. Fur‑ thermore, NUP155 was significantly and positively correlated with DNA methylation, tumor mutational burden, micro‑ satellite instability, and stemness score in most cancers. Additionally, NUP155 was also found to be involved in TIME and closely associated with tumor infiltrating immune cells and immunoregulation‑related genes. Functional enrich‑ ment analysis revealed a strong correlation between NUP155 and immunomodulatory pathways, especially antigen processing and presentation. The role of NUP155 in breast cancer has not been examined. This study, for the first time, demonstrated that NUP155 was upregulated in breast invasive carcinoma (BRCA) cells and revealed its oncogenic role in BRCA using molecular biology experiments. Thus, our study highlights the potential value of NUP155 as a bio‑ marker in the assessment of prognostic prediction, tumor microenvironment and immunotherapeutic response in pan‑cancer. Keywords NUP155, Pan‑cancer analysis, Prognosis, Immune infiltration, Immune checkpoints, Molecular biology experiments †Zi‑qiong Wang and Zhi‑xuan Wu contributed equally to this work. *Correspondence: Rong‑xing Wu [qzwrx@163.com](qzwrx@163.com)[ ](qzwrx@163.com)Xuan‑xuan Dai [dashidaixuanxuan@126.com](dashidaixuanxuan@126.com) 1 Quzhou People’s Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, 100 Minjiang Avenue, Quzhou, Zhejiang 324000, Zhejiang, China 2 Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, Zhejiang, China 3 Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China Introduction Cancer adversely affects human health and quality of life worldwide. In addition to the number of newly diagnosed cancer cases, the burden of cancer is increasing due to rapid population aging [1, 2]. The breakthrough in immune checkpoint inhibitor (ICI) therapy has enabled the development of immunotherapy, which is a novel therapeutic approach that improves the clinical outcomes of patients with cancer [3, 4]. Therefore, there is a need to explore novel immunotherapeutic targets and their roles in tumor physiology and tumor immune microenvironment (TIME). © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regu

FAQs

What question does the study address about NUP155?

It examines how NUP155 contributes to tumor physiology and the tumor immune microenvironment (TIME), including its immunological function and prognostic significance across cancer types.

What did the study find about NUP155 expression across cancers?

Bioinformatics results show NUP155 is upregulated in 26 cancer types and is associated with advanced pathological or clinical stages and poor prognosis in several cancers.

How was NUP155 linked to breast cancer specifically?

The study reports that NUP155 is upregulated in breast invasive carcinoma (BRCA) cells and demonstrates an oncogenic role for NUP155 in BRCA using molecular biology experiments.

Sep 21, 2026

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