Overview of glottic laryngeal cancer treatment recommendation changes in the NCCN guidelines from 2011 to 2022

Sep 24, 2026

Uploaded by Fahsai

Background: The treatment of glottic cancer remains challenging, particularly regarding morbidity reduction and larynx preservation. The National Comprehensive Cancer Network (NCCN) publishes guidelines supporting decisions based on tumor site, clinical stage, and patient status. Aim: Identify NCCN guideline changes for glottic cancer from 2011–2022 and describe the evidence and outcomes reported in the same period. Methods: NCCN clinical practice guidelines and related PubMed literature were reviewed and analyzed. Results: 24 guideline updates and 68 studies were identified, with key changes affecting surgical/systemic therapies, adverse feature considerations, and metastatic options; early-stage comparisons suggest similar survival with potential functional compromise. Conclusion: NCCN updates emphasize individualized care prioritizing quality of life and functional outcomes.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages16

Reading Time40 min

AccessFree to download

Abstract

Background

Aim

Methods and Results

Conclusion

Introduction

DOI: 10.1002/cnr2.1837 REVIE W Overview of glottic laryngeal cancer treatment recommendation changes in the NCCN guidelines from 2011 to 2022 Lady Paola Aristizabal Arboleda 1 | Aline Borburema Neves 1 | Hugo Fontan Kohler 2 | José Guilherme Vartanian 2 | Letícia Miliano Candelária 3 | Matheus Ferraz Borges 3 | Gisele Aparecida Fernandes 3 | Genival Barbosa de Carvalho 2 | Luiz Paulo Kowalski 2,4 | Paul Brennan 5 | Alan Roger Santos-Silva 6 | Maria Paula Curado 3 1Graduate Program, A.C. Camargo Cancer Center, So Paulo, Brazil 2Head and Neck Surgery and Otorhinolaryngology Department, A.C. Camargo Cancer Center, So Paulo, Brazil 3Group of Epidemiology and Statistics on Cancer, A.C. Camargo Cancer Center, So Paulo, SP, Brazil 4Head and Neck Surgery Department, Faculdade de Medicina, Universidade de So Paulo, So Paulo, Brazil 5International Agency for Research on Cancer, Genomic Epidemiology Branch, Lyon, France 6Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Campinas, Brazil Correspondence Maria Paula Curado, Group of Epidemiology and Statistics on Cancer, A.C. Camargo Cancer Center, Rua Tagua 440, Liberdade, 01508-020, So Paulo, SP, Brazil. [Email:](Email: mp.curado@accamargo.org.br)[ mp.curado@accamargo.org.br](Email: mp.curado@accamargo.org.br) Luiz Paulo Kowalski, Head and Neck Surgery and Otorhinolaryngology Department, A.C. Camargo Cancer Center, Rua Professor Antonio Prudente 211, Liberdade, 01509-900, So Paulo, SP, Brazil. Email: [lpkowalski@accamargo.org.br](lpkowalski@accamargo.org.br) Funding information Fundaço de Amparo à Pesquisa do Estado de So Paulo, Grant/Award Number: 2018/26297-3 Abstract Background: The treatment of glottic cancer remains challenging, especially with regard to morbidity reduction and larynx preservation rates. The National Comprehensive Cancer Network (NCCN) has published guidelines to aid decision-making about this treatment according to the tumor site, clinical stage, and patient medical status. Aim: The present review was conducted to identify changes in the NCCN guidelines for glottic cancer treatment made between 2011 and 2022 and to describe the published evidence concerning glottic cancer treatment and oncological outcomes in the same time period. Methods and Results: Clinical practice guidelines for head and neck cancer published from 2011 up to 2022 were obtained from the NCCN website ([www.NCCN.org](www.NCCN.org)) . Data on glottic cancer treatment recommendations were extracted, and descriptive analysis was performed. In addition, a review of literature registered in the PubMed database was performed to obtain data on glottic cancer management protocols and treatment outcomes from randomized controlled trials, systematic reviews, and meta-analyses published from 2011 to 2022 . In total, 24 NCCN guidelines and updates and 68 relevant studies included in the PubMed database were identified. The main guideline changes made pertained to surgical and systemic therapies, the consideration of adverse features, and new options for the treatment of metastatic disease at initial presentation. Early-stage glottic cancer received the most research attention, with transoral endoscopic laser surgery and radiotherapy assessed and compared as the main treatment modalities. Reported associations between treatment types and survival rates for this stage of glottic cancer appear to be similar, but functional outcomes can be highly compromised. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC. Conclusion: NCCN panel members provide updated recommendations based on currently accepted treatment approaches for glottic cancer, constantly reviewing new surgical and non-surgical techniques. The guidelines suppo

FAQs

What is the main purpose of the review?

To identify changes in the NCCN guidelines for glottic cancer between 2011 and 2022 and to describe the evidence and oncological outcomes reported in that period.

How were the guideline changes and evidence sources obtained?

The review extracted glottic cancer treatment recommendations from NCCN website guidelines and performed a literature review in PubMed for trials, systematic reviews, and meta-analyses published from 2011 to 2022.

What categories of guideline changes were most prominent?

Key changes pertained to surgical and systemic therapies, consideration of adverse features, and new options for treating metastatic disease at initial presentation.

Sep 24, 2026

Uploaded by Fahsai