Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives - Review

Sep 21, 2026

Uploaded by Miles

Head and neck squamous cell carcinoma (H&NSCC) is a complex anatomic, biological, and genetic disease involving over 1000 genes implicated in its oncogenesis. This review limits its search and description to genes implicated in the onco-ontogeny of derivatives from the first pharyngeal arch, connecting developmental origins with cancer biology. The work aims to consolidate mechanistic insight for understanding tumor initiation and progression within a developmental framework.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages34

Reading Time1 h 26 min

AccessFree to download

Abstract

Key disease background

Scope of gene-focused review

Developmental and oncogenic implications

Review Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives Daniel Sat-Muñoz 1,2,3,4, *, Luz-Ma.-Adriana Balderas-Peña 1,2,4,5, *, Eduardo Gómez-Sánchez 2,6, Brenda-Eugenia Martínez-Herrera 7, Benjamín Trujillo-Hernández 8, Luis-Aarón Quiroga-Morales 9, Mario Salazar-Páramo 10, Ingrid-Patricia Dávalos-Rodríguez 11, Carlos M. Nuño-Guzmán 6,12, Martha-Cecilia Velázquez-Flores 1,13, Miguel-Ricardo Ochoa-Plascencia 2,6, María-Ivette Muciño-Hernández 2,6, Mario-Alberto Isiordia-Espinoza 14, Mario-Alberto Mireles-Ramírez 15 and Eduardo Hernández-Salazar 16 Citation: Sat-Muñoz, D.; BalderasPeña, L.-M.-A.; Gómez-Sánchez, E.; Martínez-Herrera, B.-E.; TrujilloHernández, B.; Quiroga-Morales, L.-A.; Salazar-Páramo, M.; DávalosRodríguez, I.-P.; Nuño-Guzmán, C.M.; Velázquez-Flores, M.-C.; et al. Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives. Int. J. Mol. Sci. 2024, 25, 9979. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms25189979 Academic Editors: Marko Tarle and Ivica Lukši´c Received: 16 July 2024 Revised: 6 September 2024 Accepted: 14 September 2024 Published: 16 September 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 Departamento de Morfología, Centro Universitario de Ciencis de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico; [c.velazquez@academicos.udg.mx](c.velazquez@academicos.udg.mx) 2 Cuerpo Académico UDG-CA-874, Ciencias Morfológicas en el Diagnóstico y Tratamiento de la Enfermedad, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico; [eduardo.gsanchez@academicos.udg.mx](eduardo.gsanchez@academicos.udg.mx) (E.G.-S.); [miguel.oplascencia@academicos.udg.mx](miguel.oplascencia@academicos.udg.mx) (M.-R.O.-P.); [ivette.mucino@academicos.udg.mx](ivette.mucino@academicos.udg.mx) (M.-I.M.-H.) 3 Unidad Médica de Alta Especialidad (UMAE), Departamento Clínico de Cirugía Oncológica, Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico 4 Comité de Tumores de Cabeza y Cuello, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico 5 Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico 6 División de Disciplinas Clínicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico; [carlosnunoguzman@hotmail.com](carlosnunoguzman@hotmail.com) 7 Departamento de Nutrición y Dietética, Hospital General de Zona \#1, Instituto Mexicano del Seguro Social, OOAD Aguascalientes, Boulevard José María Chavez \#1202, Fracc, Lindavista, Aguascalientes 20270, Mexico; [bren.mtzh16@gmail.com](bren.mtzh16@gmail.com) 8 Posgrado en Ciencias Médicas, Universidad de Colima, Colima 28040, Mexico; [trujillobenjamin@hotmail.com](trujillobenjamin@hotmail.com) 9 Unidad Académica de Ciencias de la Salud, Clínica de Rehabilitación y Alto Rendimiento ESPORTIVA, Universidad Autónoma de Guadalajara, Zapopan 45129, Mexico; [luisquiroga@hotmail.com](luisquiroga@hotmail.com) 10 Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Academia de Inmunología, Guadalajara 44340, Mexico; [mario.sparamo@academicos.udg.mx](mario.sparamo@academicos.udg.mx) 11 Departamento de Biología Molec

FAQs

What disease is the review focused on?

The review focuses on head and neck squamous cell carcinoma (H&NSCC), described as a complex anatomic, biological, and genetic disease.

What is the specific scope regarding genes?

The review limits its search and description to genes implicated in the onco-ontogeny of derivatives from the first pharyngeal arch.

Why is the first pharyngeal arch relevant to the discussion?

The first pharyngeal arch is used as a developmental origin framework to connect oncogenesis-related genes with cancer development and progression.

Sep 21, 2026

Uploaded by Miles