NAPLEX Questions - 10 Free Practice Q&A

Sep 17, 2026

Uploaded by Dipper

Free NAPLEX practice questions with explanations covering core clinical reasoning and medication dosing. Topics include switching antibiotics for MSSA with beta-lactam allergy, interpreting direct Coombs test–associated drugs, calculating infusion rates for milrinone from a concentration and weight-based order, selecting standard weekly alendronate dosing, identifying medications that lower seizure threshold, and performing alteplase bolus/infusion volume calculations. Also included are insulin regimen adjustments after a 10% total daily dose reduction and assessing beta-blockers with proven mortality benefit in systolic CHF.

LanguageEnglish

CategoryExam

FormatPDF

Pages9

Reading Time23 min

AccessFree to download

Question 1

Question 2

Question 3

Question 4

Question 5

Question 6

Question 7

Question 8

Free Questions for NAPLEXShared by Brewer on 09-08-2024 For More Free Questions and Preparation ResourcesCheck the Links on Last Page # Question 1 JT is a 58-year-old women who is on vancomycin empirically for pyomyositis confirmed by MRI.Surgical debridement has successfully removed infected tissue and pus.C&S of the infectedtissue comes back MSSA sensitive to everything on the panel.JT is allergic to PCN(rash),she hashad cephalosporin for her UTI in the past with no problem. What would be the most appropriate antibiotics to switch to while JT is still in the hospital? Options: A-Oxacillin B-Doxycycline C-Ceftaroline D-Daptomycin E-Cefazolin Answer: E Explanation: Cefazolin or an antistaphylococcal penicillin(oxacillin or nafcillin)is recommended for this patienttbecause the C&S results indicate MSSA.Since the patient develops a rash to penicillins,it wouldbe acceptable to use cefazolin in this case. https://academic.oup.com/cid/article/59/2/e10/2895845/Practice-Guidelines-for-the-Diagnosis-and Question 2 Question Type:MultipleChoice Which of these medicines is well-known to cause a positive direct Coombs test? Options: B-Labetalol C-Hydralazine D-Nifedipine Section:(none) Explanation Answer: A Explanation: The direct Coombs test is used to test for autoimmune hemolyticanemia --a condition in whichthe body attacks red blood cells,leading to anemia.Some drugs can cause a positive directCoombs test --methyldopa being one of the most well-known(via IgG-mediated type Il hypersensitivity reaction).Other drugs that can cause this effect include quinidine (IgM-mediatedactivation)and penicillins(at very high doses). # Question 3 Question Type:MultipleChoice An order is received to start Milrinone at 0.75mcg/kg/min,Milrinone comes as 20mg/100ml D5W.What is the infusion rate in mL/hr?Patient weighs 115kg. Options: A-86 mls/hr B-13 mls/hr C-25.9 mls/hr D-43 mls/hr E-7 mls/hr Answer: C Explanation: (1mg/1000mcg)=25.875mL/hr Rate of infusion of Milrinone # Question 4 Question Type:MultipleChoice What is the standard oral weekly dose of alendronate given to treat osteoporosis? Options: A-10mg B-70mg C-140mg D-200mg Answer: B # Explanation: The standard oral dose of alendronate in the treatment of osteoporosis is 70mg weekly --or10mg per day. # Question 5 Question Type:MultipleChoice Which of the following medication can lower seizures threshold? Options: A-Bupropion B-Tramadol C-Clozapine D-Thiothixene E-All of the above can lower seizure threshold Answer: F Explanation: Seizure threshold can be lowered by bupropion,chlorpromazine,clozapine,maprotiline,olanzapine,thioridazine,thiothixene,and tramadol. # Question 6 Question Type:MultipleChoice Alteplase is ordered for a 72 YOM who weighs 68kg for Ischemic stroke.The ER physician wouldlike you to dose.As an ER pharmacist you know the dose is 0.9 mg/kg IV(not to exceed 90 mg);give 10%of the total dose as an IV bolus over 1 minute,then give the remaining 90%as an IVinfusion over 60 minutes.After reconstitution,the concentration of Altaplace is 1mg/ml.Howmany ml is needed for the bolus and how many ml is needed for the infusion?Round to thenearest ml. Options: A-6ml IV bolus,followed by 55mL IV over 60 minutes B-4ml IV bolus,followed by 57mLIV over 60 minutes C-3ml IV bolus,followed by 58mL IV over 60 minutes D-8ml IV bolus,followed by 52mLIV over 60 minutes E-9ml IV b

FAQs

How do the MSSA culture results and penicillin allergy influence antibiotic switching in Question 1?

MSSA sensitive to the panel supports switching to an antistaphylococcal agent such as cefazolin or an antistaphylococcal penicillin. Because the patient develops a rash with penicillins, cefazolin is considered acceptable in this case.

Which medications are known to cause a positive direct Coombs test, according to Question 2?

Methyldopa is one of the best-known causes via IgG-mediated type II hypersensitivity. Quinidine and penicillins at very high doses can also produce positive direct Coombs results.

How are infusion volumes calculated for milrinone and alteplase in the dosing questions?

Milrinone rate is computed from the ordered mg/kg/min dose using the vial concentration (20 mg/100 mL D5W) to obtain mL/hr. Alteplase requires weight-based total dose (0.9 mg/kg, max 90 mg), then 10% as an IV bolus over 1 minute and 90% as an IV infusion over 60 minutes, using the reconstituted concentration (1 mg/mL) to convert mg to mL.

Sep 17, 2026

Uploaded by Dipper