MSC-derived extracellular vesicles - Precision miRNA delivery for overcoming cancer therapy resistance

Sep 23, 2026

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Cancer remains a major worldwide health challenge due to toxicity, limited effectiveness, and the emergence of treatment resistance, creating a need for improved remedies. Exosomes, small extracellular vesicles involved in intercellular communication, carry diverse cargo such as microRNAs and other biomolecules, making them promising for cancer therapy. Mesenchymal stem cells (MSC) can promote vessel formation, prevent cell death, and regulate immunity. This review analyzes MSC-derived exosomes for miRNA encapsulation, strategies to improve uptake and stability, potential applications, associated difficulties, and future clinical directions.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages16

Reading Time40 min

AccessFree to download

Introduction

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVS)

Characteristics of MSC-EVs

Isolation and characterization

Regenerative Therapy 29 (2025) 303e318 Contents lists available at ScienceDirect Regenerative Therapy journal homepage: [http://www. elsevier. com/locate/reth](http://www. elsevier. com/locate/reth) | Review
MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance | | | | | --- | --- | --- | --- | | Ahsas Goyal a, Muhammad Afzal b, Kavita Goyal c, Subbulakshmi Ganesan d, Mukesh Kumari e, S. Sunitha f, Aniruddh Dash g, Suman Saini h, Mohit Rana i, Gaurav Gupta j, o, Haider Ali k, Ling Shing Wong l, Vinoth Kumarasamy m, *, Vetriselvan Subramaniyan n
a Institute of Pharmaceutical Research, GLA University, Mathura, UP, India
b Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah, 21442, Saudi Arabia c Department of Biotechnology, Graphic Era (Deemed to be University), Clement Town, 248002, Dehradun, India
d Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, Indiae Department of Applied Sciences-Chemistry, NIMS Institute of Engineering & Technology, NIMS University Rajasthan, Jaipur, India f Department of CHEMISTRY, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
g Department of Orthopaedics IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751030, India h Department of Chemistry, Chandigarh Engineering College, Chandigarh Group of Colleges-Jhanjeri, Mohali, 140307, Punjab, India i Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
j Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India
k Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India l Faculty of Health and Life Sciences, INTI International University, Nilai, 71800, Malaysia
m Department of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, 56000, Kuala Lumpur, Malaysia
n Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, 47500, Subang Jaya, Selangor, Malaysia o Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates | | | | | a r t i c l e i n f o | | a b s t r a c t | | | Article history:
Received 4 February 2025
Received in revised form
4 March 2025
Accepted 18 March 2025 | | Cancer remains a prominent worldwide health concern, presenting existing therapies with frequent difﬁculties, including major toxicity, limited effectiveness, and treatment resistance emergence. These issues highlight the necessity for novel and enhanced remedies. Exosomes, tiny extracellular vesicles that facilitate intercellular communication, have attracted interest for their potential medicinal applications. Carrying a variety of molecules, including microRNAs, small interfering RNAs, long non-coding RNAs, proteins, lipids, and DNA, these vesicles are positioned as promising cancer treatment options. Current studies have increasingly investigated the capacity of microRNAs as a strategic approach for combating malignancy. Mesenchymal stem cells (MSC) are recognized for their aptitude to augment blood vessel formation, safeguard against cellular death, and modulate immune responses. Consequently, researchers examine exosomes derived from MSCs as a safer, non-cellular choice over therapies employing MSCs, which risk undesirable differentiation. The focus is shifting towards employing miRNA-encapsulated exosomes sourced from MSCs to target and heal cancerous cells selectively. However, the exact functions of miRNAs within MSC-derived exosomes in the context of cancer are still not fully understood. Additional exploration is necessary to clarify the role o

FAQs

What are the key gaps that motivate further research on miRNAs in MSC-derived exosomes?

The precise functions of miRNAs within MSC-derived exosomes in cancer are not fully understood, requiring additional work to clarify roles in malignancy progression and identify therapeutic targets.

Sep 23, 2026

Uploaded by Mia