miR-17-92a-1 cluster host gene - a key regulator in colorectal cancer development and progression

Sep 22, 2026

Colorectal cancer (CRC) is driven by multifactorial environmental, dietary, age, and genetic influences, yet the exact genetic mechanisms of its pathogenesis remain incompletely defined. This research focuses on the miR-17-92a-1 cluster host gene (MIR17HG) and its associated miRNAs within the non-coding RNA repertoire. The study investigates regulatory mechanisms, structural features, functional roles, and possible diagnostic and therapeutic implications. Results indicate MIR17HG and related miRNAs are upregulated in CRC versus normal tissues and may contribute to metastatic behavior, apoptosis regulation, proliferation, and drug resistance.

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Clinical and Experimental Medicine (2024) 24:85 [https://doi.org/10.1007/s10238-024-01331-1](https://doi.org/10.1007/s10238-024-01331-1) miR‑17‑92a‑1 cluster host gene: a key regulator in colorectal cancer development and progression Amirhossein Mohajeri Khorasani1,2,3 · Samane Mohammadi1,2,3 · Alireza Raghibi4 · Behzad Haj Mohammad Hassani1,2,3 · Behina Bazghandi5 · Pegah Mousavi2 Received: 22 December 2023 / Accepted: 14 March 2024 / Published online: 25 April 2024 © The Author(s) 2024 Abstract Colorectal cancer (CRC), recognized among the five most prevalent malignancies and most deadly cancers, manifests multifactorial influences stemming from environmental exposures, dietary patterns, age, and genetic predisposition. Although substantial progress has been made in comprehending the etiology of CRC, the precise genetic components driving its pathogenesis remain incompletely elucidated. Within the expansive repertoire of non-coding RNAs, particular focus has centered on the miR-17-92a-1 cluster host gene (MIR17HG) and its associated miRNAs, which actively participate in diverse cellular processes and frequently exhibit heightened expression in various solid tumors, notably CRC. Therefore, the primary objective of this research is to undertake an extensive inquiry into the regulatory mechanisms, structural features, functional attributes, and potential diagnostic and therapeutic implications associated with this cluster in CRC. Furthermore, the intricate interplay between this cluster and the development and progression of CRC will be explored. Our findings underscore the upregulation of the miR-17-92a-1 cluster host gene (MIR17HG) and its associated miRNAs in CRC compared to normal tissues, thus implying their profound involvement in the progression of CRC. Collectively, these molecules are implicated in critical oncogenic processes, encompassing metastatic activity, regulation of apoptotic pathways, cellular proliferation, and drug resistance. Consequently, these findings shed illuminating insights into the potential of MIR17HG and its associated miRNAs as promising targets for therapeutic interventions in the management of CRC. Graphical abstract Keywords MIR17HG · miR-17-92a-1 cluster host gene · Colorectal cancer · Non-coding RNA · miRNA Abbreviations CRC Colorectal cancer Extended author information available on the last page of the article miRNA MicroRNA lncRNAcircRNA MFECOAD TCGARNA-seq miRNA-seq TMM DElncRNA DEmiRNA FC FDR ROC AUC CI CeRNA MCC KEGG GSCA CTRP GDSC GO ncRNA ATM MMP-9 VEGFC IBD CD UC Long non-coding RNA Circular RNAs Minimum free energy Colon adenocarcinoma The cancer genome atlas RNA-sequencing MicroRNA-sequencing Mean of M values Differentially expressed long non-coding RNA Differentially expressed microRNAs Fold change False discovery rate Receiver operating characteristic Area under the curve Confidence interval Competing endogenous RNA Maximal clique centrality Kyoto Encyclopedia of Genes and Genomes Gene set cancer analysis Cancer therapeutics response portal Genomics of drug sensitivity in cancer Gene ontology Non-coding RNA Ataxia-telangiectasia mutated Matrix metallopeptidase 9 Vascular endothelial growth factor C Inflammatory bowel disease Crohn’s disease Ulcerative colitis Introduction Colorectal cancer (CRC) stands as a highly prevalent global affliction, ranking as the third most common cancer worldwide [1] . In terms of mortality, CRC assumes the grim position of being the second most lethal malignancy [1, 2] . Its incidence is markedly impacted by an interplay of environmental factors, lifestyle choices, dietary habits, age, and genetic predispositions [3] . While the full etiology of this disease remains elusive, substantial evidence has substantiated the pivotal role of genetic factors in its pathogenesis [4, 5] . Exceeding 75% of the human genome is subject to transcription; however, the majority

FAQs

What is the main focus of this research in colorectal cancer?

The study centers on the miR-17-92a-1 cluster host gene (MIR17HG) and its associated miRNAs, examining how this cluster may regulate CRC development and progression.

What do the findings suggest about MIR17HG in CRC?

The research reports upregulation of MIR17HG and its associated miRNAs in CRC compared with normal tissues, supporting their involvement in disease progression.

How could MIR17HG and its associated miRNAs be relevant clinically?

The study connects the cluster to oncogenic processes such as metastasis, apoptosis regulation, cellular proliferation, and drug resistance, highlighting its potential as a diagnostic and therapeutic target.

Sep 22, 2026

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