Mesenchymal stromal/stem cell-derived exosomes and genitourinary cancers - A mini review

Sep 24, 2026

Uploaded by dhado

Mesenchymal stromal/stem cell-derived exosomes are presented as promising agents for tissue repair and tumor repression, while their role in tumor formation and progression remains debated. The review focuses on recent evidence in genitourinary neoplasms, covering prostatic, ovarian, cervical, endometrial, bladder, and renal cell cancers. It highlights MSC-derived exosomes for delivering effective RNAs, offering extensive tissue compatibility, and supporting tumor identification, as a potential future therapeutic approach compared with limitations of cell therapy.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages10

Reading Time25 min

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Mesenchymal stromal/stem cell-derived exosomes and genitourinary neoplasms

MSCs and their immunomodulatory functions

Exosomes in diagnosing genitourinary neoplasms

MSC-derived exosomes as therapeutic carriers

Therapeutic relevance and current controversies

TYPE Mini Review PUBLISHED 04 January 2023 DOI 10.3389/fcell.2022.1115786 OPEN ACCESS EDITED BY Reza Shirazi, UNSW Sydney, Australia REVIEWED BY Ulanbek Zhanbyrbekuly, Astana Medical University, Kazakhstan Mohammad Saied Salehi, Shiraz University of Medical Sciences, Iran Sahar Almasi-Turk, Bushehr University of Medical Sciences, Iran *CORRESPONDENCE Farhad Rahmanifar, [rahmanifar@shirazu.ac.ir](rahmanifar@shirazu.ac.ir), [f.rahmanifar@yahoo.com](f.rahmanifar@yahoo.com) SPECIALTY SECTION This article was submitted to Stem Cell Research, a section of the journal Frontiers in Cell and Developmental Biology RECEIVED 04 December 2022 ACCEPTED 14 December 2022 PUBLISHED 04 January 2023 CITATION Salehpour A, Balmagambetova S, Mussin N, Kaliyev A and Rahmanifar F (2023), Mesenchymal stromal/stem cell-derived exosomes and genitourinary cancers: A mini review. Front. Cell Dev. Biol. 10:1115786 . doi: 10.3389/fcell.2022.1115786 COPYRIGHT © 2023 Salehpour, Balmagambetova, Mussin, Kaliyev and Rahmanifar. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Mesenchymal stromal/stem cell-derived exosomes and genitourinary cancers: A mini review Aria Salehpour 􀀁 1, Saule Balmagambetova 􀀁 2, Nadiar Mussin 􀀁 3, Asset Kaliyev 􀀁 3 and Farhad Rahmanifar 􀀁 4* 1PerciaVista R&D Co. Ltd, Shiraz, Iran, 2Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan, 3Department of Surgery No. 2, West Kazakhstan Medical University, Aktobe, Kazakhstan, 4Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Mesenchymal stromal/stem cell- (MSC-) derived exosomes are gaining popularity for their involvement in tissue repair and repressing various tumors through extensive patterns. Nevertheless, the impact of extracellular vesicles produced by stem cells on tumor formation and progression is controversial and seems to depend on several factors. The utilization of MSCs’ various capabilities in urogenital neoplasms is widely regarded as a potential future therapeutic as well. These genitourinary neoplasms include prostatic neoplasms, ovarian neoplasms, cervical neoplasms, endometrial neoplasms, bladder neoplasms, and renal cell neoplasms. The present study has concentrated on the most recent information on genitourinary neoplasms employing MSCs derived exosomes’ many capabilities, such as delivering effective RNAs, extensive tissue compatibility, and speciﬁcity with tumor identiﬁcation without inherent limitations of cell therapy. KEYWORDS Mesenchymal Stromal/Stem Cell, MSCs, Exosomes, miRNAs, Urogenital neoplasms, Genitourinary neoplasms, Reproductive neoplasms, Reproductive cancers Abbreviations: CDKs, cyclin-dependent kinases; PCa, Prostate cancer; CRPC, Castration-resistant prostate cancer; EC, Endometrial cancer; EVs, Extracellular vesicles; EXO, Exosome; hA-MSC-CM, human adipose tissue-derived mesenchymal stromal/stem cell condition media; hBM-MSC, Human bone marrow-derived mesenchymal stromal/stem cell; hL-SCs, Human liver stem cells; hUC-MSC, human umbilical cord-derived mesenchymal stromal/stem cell; lncRNA, Long non-coding RNA; MenSCs, Menstrual blood-derived stem cells; MEST, mesoderm-speciﬁc transcript; miRNA, microRNA; mir, microRNA; MSC, Mesenchymal stromal/stem cell; MSC-EXO, Mesenchymal stromal/stem cellderived exosome; OCa, Ovarian cancer; ROS, Reactive oxygen species; SEPT2, Septin 2; WT, Wilms tumor. Frontiers in Cell and Developmental Biology 01 [frontiersin.org](frontiersin.org) Mesenchymal stromal/stem cell

FAQs

What is the main focus of this mini review?

The mini review concentrates on recent information about MSC-derived exosomes and their capabilities in genitourinary neoplasms, including multiple cancer types.

Why is the role of stem-cell extracellular vesicles in cancer considered controversial?

The document states the impact is debatable and appears to depend on the EV source, the tumor type, and the mode of exosome therapy.

Which genitourinary cancer categories are discussed?

It lists prostatic neoplasms, ovarian neoplasms, cervical neoplasms, endometrial neoplasms, bladder neoplasms, and renal cell neoplasms.

Sep 24, 2026

Uploaded by dhado