Medication-Related Osteonecrosis of the Jaw - An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force

Sep 29, 2026

Medication-related osteonecrosis of the jaw (MRONJ) has become a growing clinical challenge worldwide due to population aging and increasing use of antiresorptive agents. To provide tailored clinical guidance, a Korean multidisciplinary task force convened to develop an evidence-based 2025 position statement. The manuscript documents the background, rationale, and collaborative framework supporting the recommended approach, aiming to inform clinical decision-making and standardize patient management strategies.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages24

Reading Time1 h 0 min

AccessFree to download

Background

Rationale for an Evidence-Based Position Statement

Multidisciplinary Task Force Approach

Intended Clinical Guidance

Special Article Endocrinol Metab 2025;40:787-810 [https://doi.org/10.3803/EnM.2025.2712](https://doi.org/10.3803/EnM.2025.2712)[ ](https://doi.org/10.3803/EnM.2025.2712)[pISSN 2093-596X](pISSN 2093-596X) · eISSN 2093-5978 Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force Jin-Woo Kim1, Sung-Hye Kong2, Jae-Young Kim3, Mi Kyung Kwak4, Jun-Young Kim5, Ji-Hyeon Oh6, Hyung-Youl Park7, BeomTaek Kim8, Young-Kyun Lee9, Jeong Joon Han 10, Moon-Young Kim11, Yong Jun Choi12, Yong-Dae Kwon 13, Kwang-Sup Song 14, Beom-Jun Kim15, Sun-Jong Kim 1, Seung-Hoon Baek16, Dong Ock Lee17, Han Seok Choi 18, Ha Young Kim19, Tae-Geon Kwon20 1Department of Oral and Maxillofacial Surgery, Ewha Womans University College of Medicine, Seoul; 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam; 3Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University College of Dentistry, Seoul; 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong; 5Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul; 6Department of Oral and MaxilloFacial Surgery, Dental Hospital, Gangneung-Wonju National University, Gangneung; 7Department of Orthopedic Surgery, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul; 8Department of Family Practice & Community Health, Ajou University School of Medicine and Graduate School of Medicine, Suwon; 9Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam; 10Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul; 11Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan; 12Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon; 13Department of Oral and Maxillofacial Surgery, Kyung Hee University College of Dentistry; 14Department of Orthopaedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine; 15Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical | Received: 3 October 2025, Revised: 11 November 2025, Accepted: 17 November 2025
Corresponding authors: Jin-Woo Kim
Department of Oral and Maxillofacial Surgery, Ewha Womans University College of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Korea
Tel: +82-2-2650-2720, Fax: +82-2-2650-2754, E-mail:[jwkim84@ewha.ac.kr](jwkim84@ewha.ac.kr)
Dong Ock Lee
Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Korea
Tel: +82-10-3737-3436, Fax: +82-31-920-1238, [E-mail:](E-mail: dolee@ncc.re.kr)[ dolee@ncc.re.kr](E-mail: dolee@ncc.re.kr)
Han Seok Choi
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang 10326, Korea
Tel: +82-31-961-5777, Fax: +82-31-961-8369, [E-mail:](E-mail: hschoi402@dumc.or.kr)[ hschoi402@dumc.or.kr](E-mail: hschoi402@dumc.or.kr)
Ha Young Kim
Division of Endocrinology, Department of Internal Medicine, GangneungAsan Hospital, University of Ulsan College of Medicine, 38 Bangdong-gil, Gangneung 25440, Korea
Tel: +82-33-610-4580, Fax: +82-33-641-8310, [E-mail:](E-mail: hykimmd@hanmail.net)[ hykimmd@hanmail.net](E-mail: hykimmd@hanmail.net) | Tae-Geon Kwon
Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University, 2175 Dalgubeol-daero, Jung-gu, Daegu 41940, Korea Tel: +82-53-600-7574, Fax: +82-53-426-5365, [E-mail:](E-mail: kwondk@knu.ac.kr)[ kwondk@knu.ac.kr](E-mail: kwondk@knu.ac.kr)
This manuscript is

FAQs

Why is medication-related osteonecrosis of the jaw (MRONJ) a growing problem?

MRONJ is increasingly reported worldwide alongside population aging and more frequent use of antiresorptive agents.

What is the purpose of the 2025 position statement?

It provides tailored, evidence-based clinical guidance to support standardized decision-making for MRONJ.

Who developed the recommendations?

The document is developed by a Korean multidisciplinary task force representing multiple clinical and research groups.

Sep 29, 2026

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