Malignant salivary gland tumors in Brazil - Epidemiology, treatment patterns, and survival outcomes in public Brazilian population

Sep 22, 2026

Upload by Cipher

Rare and heterogeneous malignant salivary gland tumors receive limited population-based evidence in low- and middle-income settings. This study analyzes national-level registry data to characterize epidemiology and uses retrospective longitudinal data from the São Paulo State Cancer Registry to estimate overall survival. Histologies are grouped into five categories, and survival is assessed across them. Multivariable models evaluate prognostic factors, highlighting demographic, stage, and histologic effects.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages13

Reading Time33 min

AccessFree to download

Background

Methods

Results

Conclusions

Original Article Malignant salivary gland tumors in Brazil: epidemiology, treatment patterns, and survival outcomes in public Brazilian population Aline Lauda Freitas Chaves1\#^, Leandro Luongo Matos2,3\#^, Patrícia Klarmann Ziegelmann4^, Gustavo Nader Marta5^, Gilberto de Castro Junior6^, Guilherme Harada7^, Carmen Silvia Passos Lima8^, Ligia Traldi Macedo9^, Marcos Aurelio Fonseca Magalhaes Filho10^, Milena Perez Mak6^, Pedro de Marchi11^, Thiago Bueno de Oliveira12^, Alan Roger Santos-Silva13^, Luiz Paulo Kowalski14,15^, William Nassib William Jr16*^ 1DOM Clínica de Oncologia, Grupo Oncoclínicas, São Paulo, Brazil; 2Department of Head and Neck Surgery, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Universidade de São Paulo (Icesp HCFMUSP), São Paulo, Brazil; 3Surgery, Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil; 4Graduate Program in Epidemiology and Statistics Department, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; 5Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil; 6Serviço de Oncologia Clínica, Instituto do Câncer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil; 7Clinical Oncology, Hospital Sírio-Libanês, São Paulo, Brazil; 8Departamento de Radiologia e Oncologia, Universidade Estadual de Campinas, São Paulo, Brazil; 9Department of Oncology and Radiology, University of Campinas, São Paulo, Brazil; 10Beneficência Portuguesa de São Paulo, São Paulo, Brazil; 11Grupo Oncoclinicas, Riyadh, Saudi Arabia; 12A. C. Camargo Cancer Center, São Paulo, Brazil; 13Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, São Paulo, Brazil; 14Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil; 15Department of Head and Neck Surgery and Otorhinolaryngology, A C Camargo Cancer Center, São Paulo, Brazil; 16Grupo Oncoclínicas, São Paulo, Brazil Contributions: (I) Conception and design: ALF Chaves, LP Kowalski, WN William Jr; (II) Administrative support: PK Ziegelmann; (III) Provision of study materials or patients: PK Ziegelmann; (IV) Collection and assembly of data: LL Matos, PK Ziegelmann; (V) Data analysis and interpretation: LL Matos, PK Ziegelmann; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. \#These authors contributed equally to this work. *This author contributed to this work as a senior author. Correspondence to: Leandro Luongo Matos, MD, PhD. Department of Head and Neck Surgery, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Universidade de São Paulo (Icesp HCFMUSP), Av. Dr. Enéas de Carvalho Aguiar, 255–8th Floor–Room 8174, São Paulo 05403-000, Brazil; Surgery, Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil. Email: [l.matos@fm.usp.br](l.matos@fm.usp.br). Background: Malignant salivary gland tumors are rare and heterogeneous neoplasms, and populationbased data from low-and middle-income countries remain scarce. This study aimed to describe the epidemiology, treatment patterns, overall survival (OS), and prognostic factors of salivary gland cancers in Brazil. Methods: A cross-sectional study using national-level data obtained from the Brazilian Hospital Cancer Registry Integrator describes epidemiological aspects while a retrospective longitudinal study was performed to assess OS using data from the São Paulo State Cancer Registry [Fundação Oncocentro de São Paulo (FOSP)] . Histologies were grouped into five categories: acinic cell carcinoma, adenocarcinoma/ductal carcinomas, biphasic tumors, mucoepidermoid carcinoma, and not otherwise specified (NOS) . ^ ORCID: Aline Lauda Freitas Chaves, 0000-0002-6759-9463; Leandro Luongo Matos, 0000-0002-5068-8208; Patrícia Klarmann Ziegelmann, 0000-0002-2851-2011; Gustavo Nader Marta, 0000-0002-3298-3684; Gilberto de Castro Junior, 0000-0

FAQs

What was the study’s main objective for malignant salivary gland tumors in Brazil?

To describe epidemiology, treatment patterns, overall survival, and prognostic factors for salivary gland cancers using population-based Brazilian registry data.

How were the study data sources used?

National-level data were used to describe epidemiological aspects, and retrospective longitudinal data from the São Paulo State Cancer Registry were used to assess overall survival.

Which factors were independently associated with poorer prognosis?

Advanced age, male sex, advanced clinical stage, and histological subtype were independently associated with worse outcomes in multivariable analyses.

Sep 22, 2026

Upload by Cipher