Long-term outcomes following the resection of screen-detected right-sided colon cancer

Q: What question does the study address about screen-detected right-sided colon cancer?

It compares relative outcomes after resection of screen-detected right-sided colon cancer with outcomes in symptomatic cases, including both elective and emergency resections.

Q: How was the study designed and who were the participants?

A prospective observational cohort enrolled patients undergoing right-sided colectomy for colon cancer from 2010 to 2020, including screen-detected and symptomatic patients. Participants were followed for long-term recurrence and survival.

Q: What differences in outcomes were observed at 5 years after resection?

Overall survival at 5 years was higher for screen-detected patients than for elective and emergency symptomatic groups (85.4% vs 75.4% vs 53.1%). Recurrence at 5 years was lower for screen-detected patients (8% vs 15.1% vs 22.5%).

Sep 21, 2026

Uploaded by Theodora

Background: Relative outcomes after resection of screen-detected right-sided colon cancer versus symptomatic cases remain unclear. This prospective observational cohort evaluates short- and long-term results after right-sided colectomy, contrasting screen-detected patients with symptomatic groups undergoing elective or emergency resections. Methods: Patients treated from 2010–2020 in a tertiary unit were followed for long-term recurrence and survival. Results include differences in tumor stage distribution, R0 resection rates, overall survival, and 5-year recurrence. Discussion: Screen-detected right-sided cancers show lower recurrence and better survival after resection than symptomatic groups.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages9

Reading Time23 min

AccessFree to download

Abstract

Background

Methods

Results

Discussion

Introduction

Study rationale and gap

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Data variables

DOI: 10. 1002/wjs.12409 ORIGINAL RESEARCH Long‐term outcomes following the resection of screen‐ detected right‐sided colon cancer James Lucocq1 | Thomas Trinder2 | Elli Symeonidou3 | Katy Homyer3 | Hassan Baig2 | Pradeep Patil1 | Girivasan Muthukumarasamy4 1Ninewells Hospital, Dundee, UK 2University Hospital, Ayr, UK 3Western General Hospital, Edinburgh, UK 4Victoria Hospital Kirkcaldy, Kirkcaldy, UK Correspondence James Lucocq. Email: [James.lucocq@nhs.scot](James.lucocq@nhs.scot) Abstract Background: The relative outcomes following the resection of screen‐ detected right‐sided colon cancer compared to symptomatic cases are unknown. In this study, short and long‐term outcomes after right‐sided colectomy in screen‐detected colon cancer are compared with symptomatic cases, both emergency and elective. Methods: A prospective observational cohort study of patients, including both screen‐detected and symptomatic patients (elective and emergency resections), undergoing right‐sided colectomy for colon cancer (2010–2020) in a tertiary care unit was conducted. Each patient was followed up for long‐ term recurrence and survival. Results: A total of 909 patients (median age, 70; IQR, 58–82; male, 52%) were included (151 patients (16 .6%) screen‐detected; 598 (65 .8%) elective and 160 (17 .6%) emergency) . Screen‐detected patients were more likely to have T1 or T2 lesions compared to elective and emergency groups (T1: 14.6% vs. 3.8% vs. 0.6% p < 0.001; T2: 16.6% vs. 8.9% vs. 3. 1% p < 0.001), but were less likely to have T3 or T4 lesions (p < 0.001), respectively. Rates of N0 were higher in the screen‐detected group (68 .9% vs. 63.5% vs. 41.9%, respectively; p < 0.001) . 98% of the screen‐detected group achieved R0 resection compared to 93.3% of elective and 79.4% of emergency patients (p < 0.001) . At 5‐years following resection, overall survival for the screen‐detected, elective, and emergency groups were 85.4%, 75.4%, and 53. 1%, respectively (p < 0.001) . Recurrence at 5‐year post‐resection were 8%, 15. 1%, and 22.5% for the screen‐detected, elective, and emergency groups, respectively (p < 0.001) . Discussion: When considering right‐sided colon cancer alone, screen‐ detected cancers have a lower long‐term recurrence rate, lower rates of postoperative complication, and superior survival compared to symptomatic groups following resection. KEYWORDS colon cancer, recurrence, resection, screening, survival This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Author(s) . World Journal of Surgery published by John Wiley & Sons Ltd on behalf of International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC) . 1 | INTRODUCTION Colorectal cancer is one of the most common cancer diagnoses worldwide, with high rates of morbidity and mortality.1–3 While patient outcomes have benefitted from the introduction of screening programs since 2006 through the early identification of asymptomatic cancers, peri‐operative outcomes compared with symptomatic patients undergoing either elective (non‐screen detected) or emergency colectomy are still largely unknown. While some studies have compared outcomesin screen‐detected (asymptomatic) groups with outcomes in elective patients diagnosed after the onset of symptoms,4,5 to the best of our knowledge no studies have compared patients specifically in right‐sided colon cancer. There is increasing evidence to support the differing characteristics and disparate outcomes between right and left‐sided cancers, including genomics, complication rates, response to adjuvant chemotherapy, and recurrence rates.6–10 Whilst studies have shown increased rates of mortality in emergent versus elective colectomy in symptomatic individuals,11–13 little is known about how these rates compare specifically in right‐sided c

FAQs

What question does the study address about screen-detected right-sided colon cancer?

It compares relative outcomes after resection of screen-detected right-sided colon cancer with outcomes in symptomatic cases, including both elective and emergency resections.

How was the study designed and who were the participants?

A prospective observational cohort enrolled patients undergoing right-sided colectomy for colon cancer from 2010 to 2020, including screen-detected and symptomatic patients. Participants were followed for long-term recurrence and survival.

What differences in outcomes were observed at 5 years after resection?

Overall survival at 5 years was higher for screen-detected patients than for elective and emergency symptomatic groups (85.4% vs 75.4% vs 53.1%). Recurrence at 5 years was lower for screen-detected patients (8% vs 15.1% vs 22.5%).

Sep 21, 2026

Uploaded by Theodora