LncRNA-MALAT1 - A Key Participant in the Occurrence and Development of Cancer - Review

Sep 24, 2026

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LncRNAs are non-coding RNA transcripts longer than 200 nucleotides that interact with DNA, RNA, and proteins to regulate malignant tumor gene expression in human tissues. They participate in key cancer-related processes including chromosomal nuclear transport at cancer sites, proto-oncogene activation and regulation, immune-cell differentiation, and cellular immune control. LncRNA-MALAT1 is described as involved in the occurrence and development of many cancers, acting as a biomarker and therapeutic target. The review summarizes lncRNA structure and functions, details mechanisms in diverse cancers, and discusses ongoing research and drug-development progress targeting MALAT1.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages14

Reading Time35 min

AccessFree to download

Abstract

Keywords

Structure of LncRNA

MALAT1 Overview

Review Scope and Drug Development

molecules Review LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer Longhui Hao 1, Wenzheng Wu 1,†, Yankun Xu 1,†, Yufan Chen 2,†, Chengzhen Meng 2, Jingyi Yun 1 and Xiaoyu Wang 1, * 1 College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China 2 College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China * [Correspondence: wangxiaoyu0504@126.com](Correspondence: wangxiaoyu0504@126.com) † These authors contributed equally to this work and share ﬁrst authorship. Citation: Hao, L.; Wu, W.; Xu, Y.; Chen, Y.; Meng, C.; Yun, J.; Wang, X. LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer. Molecules 2023, 28, 2126. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/molecules28052126](10.3390/molecules28052126) Academic Editors: Ramon Eritja and Yan Xu Received: 6 January 2023 Revised: 18 February 2023 Accepted: 21 February 2023 Published: 24 February 2023 Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . Abstract: LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides and can interact with DNA, RNA, and proteins to regulate gene expression of malignant tumors inhuman tissues. LncRNAs participate in vital processes, such as chromosomal nuclear transport in the cancerous site of human tissue, activation, and the regulation of proto-oncogenes, the differentiation of immune cells, and the regulation of the cellular immune system. The lncRNA metastasis-associated lung cancer transcript 1 (MALAT1) is reportedly involved in the occurrence and development of many cancers and serves as a biomarker and therapeutic target. These ﬁndings highlight its promising role in cancer treatment. In this article, we comprehensively summarized the structure and functions of lncRNA, notably the discoveries of lncRNA-MALAT1 in different cancers, the action mechanisms, and the ongoing research on new drug development. We believe our review would serve as a basis for further research on the pathological mechanism of lncRNA-MALAT1 in cancer and provide evidence and novel insights into its application in clinical diagnoses and treatments. Keywords: long non-coding RNA; lncRNA-MALAT1; cancer; mechanism; action pathway 1. Structure of LncRNA Approximately 2% of the genes in the entire genome sequence of organisms can code for proteins. Conversely, non-coding RNA molecules participate in various biological processes and have almost no protein translation functions [1] . The typical non-coding RNAs with regulatory functions include small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), and lncRNAs. Although lncRNAs lack most of their protein-coding ability, they can be transcribed by at least 80% of mammalian genomes [2], regulating the transcription and expression of other genes in tumor cells. Long non-coding RNAs (lncRNAs) belong to a group of non-coding RNA transcripts longer than 200 nucleotides. LncRNAs, as functional RNA molecules, participate in the gene expression of various diseases and inﬂuence biological processes and homeostasis. MALAT1, an important member of the lncRNA family, was the ﬁrst to be identiﬁed as LncRNA-MALAT1 . Metastasis-associated lung cancer transcript 1 (MALAT1) is closely associated with the occurrence and development of various human cancers [3] . In 2003, it was screened for several differentially expressed genes in tumor cells from patients with initial-stage non-small cell lung cancer. LncRNA-MALAT1 is an intergenic transcript that is located on human chromosome 11q13.1 and i

FAQs

What is LncRNA-MALAT1 and why is it important in cancer?

LncRNA-MALAT1 is an lncRNA closely associated with the occurrence and development of various human cancers. It is reported to serve as a biomarker and a therapeutic target, highlighting its promising role in cancer treatment.

How do lncRNAs regulate malignant tumor gene expression?

The document states that lncRNAs interact with DNA, RNA, and proteins to regulate gene expression in malignant tumors. They also participate in processes such as chromosomal nuclear transport, proto-oncogene regulation, and immune-cell differentiation.

What does the review cover regarding LncRNA-MALAT1 research?

It comprehensively summarizes lncRNA structure and function, emphasizes discoveries of lncRNA-MALAT1 in different cancers, explains action mechanisms, and reviews ongoing research including new drug development targeting lncRNA-MALAT1.

Sep 24, 2026

Uploaded by Jiven