LINC00839 in Human Disorders - Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer

Sep 21, 2026

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LINC00839 has captured significant attention across acute lung injury, osteoarthritis, and childhood obesity, as well as multiple cancer types. Aberrant LINC00839 expression is documented in diverse tumors and cell lines, where it functions as an oncogenic factor shaping tumor-associated behaviors. The review highlights regulatory impacts on key pathways including PI3K/AKT, OXPHOS, and Wnt/β-catenin, supporting therapeutic potential. Elevated expression correlates with advanced clinicopathological features and unfavorable prognoses, suggesting biomarker value and targeted intervention across disease domains.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages14

Reading Time35 min

AccessFree to download

Abstract

Keywords

Introduction

Long non-coding RNAs and disease links

LINC00839 genomic features and transcripts

Roles in non-neoplastic and neoplastic diseases

Review scope and focus

Review Ivyspring International Publisher Journal of Cancer 2024; 15(8): 2179-2192. doi: 10.7150/jca.93820 LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer Yingqiu Hu1, Yushan Hu3, Xuan Lu3, Hongliang Luo4, Ziwen Chen2􀀍 1. Emergency Department, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China 2. Department of Gastrointestinal Surgery, Ganzhou Hospital Affiliated to Nanchang University, Ganzhou, 341000, Jiangxi, China 3. Second School of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China 4. Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China. 􀀍 Corresponding author: Ziwen Chen, email: [chenziwen667@163.com](chenziwen667@163.com), Hongqi Avenue No. 16, Zhanggong District, Ganzhou, 341000, Jiangxi Province, China. © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions. Received: 2024.01.03; Accepted: 2024.02.14; Published: 2024.02.25 Abstract LINC00839 has captured significant attention within a spectrum of human disorders, including acute lung injury, osteoarthritis, and childhood obesity. Notably, aberrant expression patterns of LINC00839 have been observed across diverse cancer tissues and cell lines. LINC00839 emerges as an oncogenic factor in tumorigenesis and exerts a positive influence on tumor-associated behaviors. Its therapeutic potential for various cancers is underscored by its modulatory impact on pivotal signaling pathways, such as PI3K/AKT, OXPHOS, and Wnt/β-catenin. Additionally, LINC00839's role in reducing sensitivity to drug and radiotherapy interventions presents opportunities for targeted intervention. Furthermore, elevated LINC00839 expression indicates advanced clinicopathological features and foretells unfavorable prognoses, as validated by publications and comprehensive analyses of tumor types using TCGA datasets. This review elucidates the multiple regulatory mechanisms and functional implications of LINC00839 in various diseases, especially malignancies, emphasizing its potential as a predictive biomarker and therapeutic target across multiple disease domains in humans. Keywords: LINC00839, Neoplasms, Non-neoplastic, Biological Functions, Regulatory Mechanisms, Clinical application Introduction Long non-coding RNAs (lncRNAs) constitute a subset of non-coding functional RNAs that span over 200 nucleotides [1, 2] . In recent years, with rapid advancements in RNA sequencing and array technologies, a plethora of non-coding RNAs, including lncRNAs, have been unearthed [3-6] . The identification of novel forms of lncRNAs has piqued the interest of researchers, driving them to elucidate their biological roles. Accumulating evidence has highlighted the connection between the dysregulation of lncRNAs and the initiation and progression of diverse disorders, such as cardiovascular disease [7-9], cholestatic liver disease [10-12], and particularly malignancy [13-16] . Furthermore, in-depth investigations have illuminated the pivotal role that lncRNAsplay in the development of various diseases, exerting influence over processes such as lipid metabolism [17, 18], cellular aging [19-22], and an array of biological behaviors associated with tumors [23-28], including cell migration, invasion, and metastasis. This paradigm extends further as lncRNAs have risen as promising candidates for clinical applications, owing to the deepening exploration of the molecular mechanisms that govern the multifaceted functionalities of numerous lncRNAs. Homo sapiens (human) long Inter

FAQs

What disorders are associated with LINC00839 expression in the review?

The review links LINC00839 with acute lung injury, osteoarthritis, and childhood obesity, and also discusses its involvement in multiple cancers.

How does LINC00839 influence cancer biology according to the abstract?

It is presented as an oncogenic factor that promotes tumorigenesis and tumor-associated behaviors, including effects on key signaling pathways.

Why is LINC00839 considered important for clinical outcomes?

Higher LINC00839 expression is associated with advanced clinicopathological features and unfavorable prognoses, including poor survival outcomes.

Sep 21, 2026

Uploaded by Finn