J O U R N A L O F T H E A M E R I C A N C O L L E G E O F C A R D I O L O G Y - LATE-BREAKING CLINICAL TRIALS

Oct 22, 2026

Late-breaking clinical trials summarize nationwide and registry-based evidence on acute myocardial infarction and chronic total occlusion. Using Taiwan inpatient claim data, incidence and short-term outcomes are tracked over 1997–2011, highlighting rising NSTEMI incidence and declining in-hospital mortality, while STEMI changes are modest. A Japanese Retrograde Summit Registry analysis compares re-attempt versus initial CTO-PCI, reporting lower procedural success in re-attempt settings with more complex lesions. Additional late-breaking items cover bioresorbable vascular scaffolds in STEMI.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Late-Breaking Clinical Trials

Acute Coronary Syndromes

Chronic Total Occlusion

Bioresorbable Vascular Scaffolds

J O U R N A L O F T H E A M E R I C A N C O L L E G E O F C A R D I O L O G Y , V O L . 6 7 , N O . 1 6 , S U P P L S , 2 0 1 6 S1 LATE-BREAKING CLINICAL TRIALS | ACUTE CORONARY SYNDROMES (STEMI, NSTE-ACS)(TCTAP A-001) | | --- | | TCTAP A-001
The Temporal Trends of Incidence, Treatment, and In-Hospital Mortality of Acute Myocardial Infarction over 15 Years in a Taiwanese Population
Kuanchun Chen,1 Wei-Hsian Yin1
1Cheng Hsin General Hospital, Taiwan | | BACKGROUND The study was conducted to examine the nationwide temporal trends of incidence, treatment, and short-term outcomes for acute myocardial infarction (AMI) over a 15-year period in Taiwan. METHODS We identiﬁed patients who were hospitalized for incident AMI between 1997 and 2011 from the inpatient medical claim data set of the National Health Insurance Research Database. Age- and sexadjusted incidence and in-hospital mortality rates were calculated for AMI, and separately for ST-segment elevation and non–ST-segment elevation myocardial infarction (STEMI and NSTEMI) .
RESULTS A total of 144,634 patients were identiﬁed. The incidence rates (per 100,000 populations) of AMI increased from 30 in 1997 to 42 in 2011, which was mainly driven by the increase of NSTEMI. The inhospital mortality rate after AMI decreased from 9.1 % in 1997 to 6.5 % in 2011, which was also driven by the case mortality rate for NSTEMI. Although the in-hospital mortality rates signiﬁcantly decreased from 7.3% to 5.1% between 1997 and 2003 for STEMI, it did not change signiﬁcantly from 2004 to 2011 . Moreover, AMI patients undergoing revascularization treatment, particularly PCI, was the most important independent predictor for improved in-hospital survival.
CONCLUSION The results of this study demonstrated a recent dramatic increase in the incidence rates and a decrease in short-term mortality in patients with NSTEMI; whilst the incidence and inhospital morality of STEMI only modestly changed over time in Taiwan. Further quality improvement approaches for AMI prevention and treatment to favorably affect the incidence and outcomes from both. | | CHRONIC TOTAL OCCLUSION (TCTAP A-002) | | TCTAP A-002
Clinical Outcomes of Re-Attempt Percutaneous Coronary Intervention for Chronic Total Occlusion: Insights from Japanese Retrograde Summit Registry
Masaki Tanabe,1 Toshiya Muramatsu,2 Tsutomu Fujita,3
Atsunori Okamura,4 Makoto Muto,5 Masahisa Yamane,6
Akitsugu Oida,7 Yuji Oikawa,8 Satoru Otsuji,9 Ryohei Yoshikawa,10 Etsuo Tsuchikane11
1Dai-Ni Okamoto General Hospital, Japan; 2Saiseikai Yokohama City Eastern Hospital, Japan; 3Sapporo CardioVascular Clinic, Japan; 4Sakurabashi Watanabe Hospital, Japan; 5Saitama Prefectural Cardiovascular and Respiratory Disease Center, Japan; 6Sekishinkai Sayama Hospital, Japan; 7Takase Clinic, Japan; 8The Cardiovascular Institute, Japan; 9Higashi Takarazuka Satoh Hospital, Japan; 10Sanda City Hospital, Japan; 11Toyohashi Heart Center, Japan | BACKGROUND According to previous reports, patients with previously failed or not attempted chronic total occlusion (CTO) percutaneous coronary intervention (PCI) had a poor clinical outcome including signiﬁcantly higher rate of cardiac mortality, therefore, CTOrecanalization should be considered. On the other hand, CTO lesions which had previously attempted PCIs but failed were independent predictors as successful interventional revascularization in itself. Moreover, clinical outcomes of re-attempt PCI for CTO have not been well elucidated. The aim of this study is to evaluate clinical outcomes of re-attempt PCI for CTO lesions which had previously attempted but failed, compared to initial attempted PCI for CTO lesions via the Japanese Retrograde Summit Registry. METHODS The data of 3,185 cases between January 2009 and December 2013 from 56 centers in Japan were used for the analysis to clarify efﬁcacy and safety of re-attempt CTO-PCI. The patients were classiﬁed into two groups whether the CTO-PCI wa

FAQs

What nationwide trends were observed for acute myocardial infarction in Taiwan over 1997–2011?

Incidence of AMI increased from 30 per 100,000 in 1997 to 42 per 100,000 in 2011, driven mainly by NSTEMI. In-hospital mortality after AMI decreased from 9.1% to 6.5%, also driven by NSTEMI.

How did re-attempt CTO-PCI outcomes compare with initial CTO-PCI in the Japanese registry?

Re-attempt CTO-PCI had more complex lesions and a significantly lower procedure success rate (82.5% vs 89.1%). The re-attempt group used the retrograde approach more often and had longer procedure and imaging times.

What factor was identified as an independent predictor of procedure failure in CTO-PCI?

Calciﬁed lesion was reported as an independent predictor of procedure failure.

Oct 22, 2026

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