IRAC MoA Classification - Version 11.5 - Active Ingredients

Sep 2, 2026

Uploaded by Theodore

IRAC MoA Classification Version 11.5 (February 2026) organizes insecticidal modes of action into main groups, primary sites of action, and sub-groups defined by representative active ingredients. The classification links nerve and muscle, growth regulation, and multi-site inhibition categories to specific compound families, and flags strength of evidence for action at targeted proteins. Tables list active ingredients spanning acetylcholinesterase inhibitors, organophosphates, chloride channel blockers, sodium channel modulators, and nicotinic receptor modulators.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages42

Reading Time1 h 46 min

AccessFree to download

Main groups and primary site of action

Sub-groups and active ingredients

Evidence descriptors for targeted proteins

| IRAC MoA Classification Version 11.5 , February 2026
See section 7.4 for further information on sub-groups. See section 7.3 for criteria for descriptors of the quality of MoA information. | | | | --- | --- | --- | | Main Group and Primary Site of Action | Sub-group, class or exemplifying Active Ingredient | Active Ingredients | | 1
Acetylcholinesterase (AChE) inhibitors
Nerve action
{Strong evidence that action at this protein is responsible for insecticidal effects} | 1A
Carbamates | Alanycarb, Aldicarb, Bendiocarb, Benfuracarb, Butocarboxim, Butoxycarboxim, Carbaryl, Carbofuran, Carbosulfan, Ethiofencarb, Fenobucarb, Formetanate, Furathiocarb, Isoprocarb, Methiocarb, Methomyl, Metolcarb, Oxamyl, Pirimicarb, Propoxur, Thiodicarb, Thiofanox, Triazamate,Trimethacarb, XMC, Xylylcarb | | | 1B
Organophosphates | Acephate, Azamethiphos, Azinphos-ethyl, Azinphos-methyl, Cadusafos, Chlorethoxyfos, Chlorfenvinphos, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Coumaphos, Cyanophos, Demeton-S-methyl, Diazinon, Dichlorvos/ DDVP, Dicrotophos, Dimethoate, Dimethylvinphos, Disulfoton, EPN, Ethion, Ethoprophos, Famphur, Fenamiphos, Fenitrothion, Fenthion, Fosthiazate, Heptenophos, Imicyafos, Isofenphos, Isopropyl O-(methoxyaminothiophosphoryl) salicylate, Isoxathion, Malathion, Mecarbam, Methamidophos, Methidathion, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemeton-methyl, Parathion, Parathionmethyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphosmethyl, Profenofos, Propetamphos, Prothiofos, Pyraclofos, Pyridaphenthion, Quinalphos, Sulfotep, Tebupirimfos, Temephos, Terbufos, Tetrachlorvinphos, Thiometon, Triazophos, Trichlorfon, Vamidothion | | 2
GABA-gated chloride channel blockers | 2A
Cyclodiene Organochlorines | Chlordane, Endosulfan | | Nerve action | | | |
{Strong evidence that action at this protein is responsible for insecticidal effects} | | | | | 2B
Phenylpyrazoles (Fiproles) | Ethiprole, Fipronil | | IRAC MoA Classification Version 11.5 , February 2026
See section 7.4 for further information on sub-groups. See section 7.3 for criteria for descriptors of the quality of MoA information. | | | | --- | --- | --- | | Main Group and Primary Site of Action | Sub-group, class or exemplifying Active Ingredient | Active Ingredients | | 3
Sodium channel modulators
Nerve action
{Strong evidence that action at this protein is responsible for insecticidal effects} | 3A
Pyrethroids
Pyrethrins | Acrinathrin, Allethrin, d-cis-trans Allethrin, dtrans Allethrin, Bifenthrin, Bioallethrin, Bioallethrin S-cyclopentenyl isomer , Bioresmethrin, Cycloprothrin, Cyfluthrin, betaCyfluthrin, Cyhalothrin, lambda-Cyhalothrin, gamma-Cyhalothrin, Cypermethrin, alphaCypermethrin, beta-Cypermethrin, thetacypermethrin, zeta-Cypermethrin, Cyphenothrin ,(1R)-trans-isomers], Deltamethrin, Empenthrin (EZ)- (1R) -isomers], Esfenvalerate, Etofenprox, Fenpropathrin, Fenvalerate, Flucythrinate, Flumethrin, tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin, Permethrin, Phenothrin [(1R)-trans-isomer], Prallethrin, Pyrethrins (pyrethrum), Resmethrin, Silafluofen, Tefluthrin, Tetramethrin, Tetramethrin [(1R)-isomers], Tralomethrin, Transfluthrin, | | | 3B
DDT
Methoxychlor | DDT
Methoxychlor | | 4
Nicotinic acetylcholine receptor (nAChR) competitive modulators
Nerve action
{Strong evidence that action atone or more of this class of protein is responsible for insecticidal effects} | 4A
Neonicotinoids | Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Thiacloprid, Thiamethoxam, | | | 4B
Nicotine | Nicotine | | | 4C
Sulfoximines | Sulfoxaflor | | | 4D
Butenolides | Flupyradifurone | | | 4E
Mesoionics | Dicloromezotiaz, Fenmezoditiaz, Triflumezopyrim | | | 4F
Pyridylidenes | Flupyrimin | | 5
Nicotinic acetylcholine receptor (nAChR) allosteric modulators – Site I
Nerve action
{Strong evidence that action atone or more of

FAQs

What does IRAC MoA Classification Version 11.5 organize?

It organizes insecticidal modes of action into main groups and sub-groups based on primary sites of action and representative active ingredients.

How are sub-groups represented in the tables?

Each sub-group lists active ingredients (example compounds) associated with that mode of action class.

What guidance is provided for assessing MoA information quality?

The document references criteria for descriptors of the quality of MoA information in section 7.3 and additional details on sub-groups in section 7.4.

Sep 2, 2026

Uploaded by Theodore

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