INTERACTION OF PHYSICAL ACTIVITY, SLEEP, AND COGNITIVE FUNCTION IN STROKE - SEM AND ML APPROACHES

Q: What was the primary aim of this study?

To examine how physical activity and sleep influence cognitive function in stroke survivors and to identify potential biological mediators.

Q: Which factors were measured to evaluate cognition and mediators?

Weekly physical activity, nighttime sleep duration/latency, cognitive function (MOCA), depression severity (HAMD), and serum homocysteine (Hcy) and hs-CRP biomarkers.

Q: What did the analyses show about physical activity, sleep, and cognition?

More frequent physical activity and adequate sleep were significantly associated with higher cognitive scores, and regression identified exercise frequency and sleep duration as independent positive predictors.

Sep 29, 2026

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Cognitive impairment is common in stroke survivors, motivating exploration of modifiable lifestyle factors and their biological mechanisms. This hospital-based cross-sectional study analyzed data from 262 stroke survivors at admission, assessing weekly physical activity, nighttime sleep metrics, cognitive performance via MOCA, depressive status (HAMD), and serum homocysteine (Hcy) and hs-CRP biomarkers. Correlation and regression showed physical activity and adequate sleep linked to better cognition, while depression and higher Hcy related negatively. Structural equation modeling supported causal pathways, and machine learning identified key predictors with strong accuracy.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Study objective and rationale

Participants and data collection

Measures and biomarkers

Statistical methods (correlation, regression, SEM, ML)

Key findings and implications

Innovation in Aging, 2025, Vol. 9, No. S2 559 on cognition and indirect effects mediated by improved sleep and reduced inflammation (CFI>0.9). ML predicted cognitive impairment (accuracy>80%), identifying age, education, Hcy level, physical activity, and sleep as crucial predictors. Physical activity and sleep synergistically enhance cognition in stroke survivors via inflammatory and neurological pathways. Promoting regular exercise, optimizing sleep, and managing biomarkers may preserve cognitive function. Abstract citation ID: igaf122.1916 INTERACTION OF PHYSICAL ACTIVITY, SLEEP, AND COGNITIVE FUNCTION IN STROKE: SEM AND ML APPROACHES Mo Yi1, Lan Gao2, Li Chen3, Junxin Li4, and Tangsheng Zhong2, 1. Peking University, Beijing, Beijing, China (People’s Republic), 2. First Hospital of Jilin University, Changchun, Jilin, China (People’s Republic), 3. Jilin University, Changchun, Jilin, China (People’s Republic), 4. Johns Hopkins University, Baltimore, Maryland, United States Cognitive impairment is prevalent among stroke survivors, highlighting the importance of exploring modifiable lifestyle factors such as physical activity and sleep, along with their biological underpinnings. This study aimed to investigate how physical activity and sleep influence cognitive function in stroke survivors, examining potential biological mediators. Cross-sectional data collected at hospital admission from 262 stroke survivors (First Hospital of Jilin University, 2024) were analyzed. Measures included self-reported weekly physical activity (exercise frequency/duration), nighttime sleep (duration, latency), cognitive function (Montreal Cognitive Assessment [MOCA]), emotional status (Hamilton Depression Rating Scale [HAMD]), and Serum neurological (homocysteine [Hcy]) and inflammatory (hs-CRP) biomarkers. Participants were aged 65.4±8.2 years, 43% female, and 58% showed cognitive impairment. Correlation and regression analyses examined associations, and structural equation modeling (SEM) explored causal pathways. Machine learning (ML) methods identified key predictors of cognitive impairment. Frequent physical activity (r= 0.35, p< 0.001) and adequate sleep (r = 0.25, p < 0.001) significantly correlated with higher cognitive scores. Depression severity (r=-0.40, p < 0.001) and elevated Hcy (r=-0.36, p < 0.001) negatively correlated with cognition. Regression analyses confirmed exercise frequency (β = 0.34, p < 0.001) and sleep duration (β = 0.29, p< 0.001) as independent positive predictors of cognitive function. SEM demonstrated direct beneficial effects of physical activity (β = 0.41, p < 0.001)

FAQs

What was the primary aim of this study?

To examine how physical activity and sleep influence cognitive function in stroke survivors and to identify potential biological mediators.

Which factors were measured to evaluate cognition and mediators?

Weekly physical activity, nighttime sleep duration/latency, cognitive function (MOCA), depression severity (HAMD), and serum homocysteine (Hcy) and hs-CRP biomarkers.

What did the analyses show about physical activity, sleep, and cognition?

More frequent physical activity and adequate sleep were significantly associated with higher cognitive scores, and regression identified exercise frequency and sleep duration as independent positive predictors.

Sep 29, 2026

Upload by kopisore