Integrative Omics Analysis Reveals the Potential Value of CEACAM6 in Pan-Gastrointestinal Cancers

Sep 22, 2026

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Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) functions as a cell adhesion receptor with regulatory roles in cancer signaling, yet its significance across pan-gastrointestinal cancers is insufficiently defined. Using multi-omics bioinformatics, the study evaluates CEACAM6 expression distribution, prognostic value, and immune-related function across cancers. Analyses rely on TCGA and multiple immune/tumor microenvironment resources, including spatial transcriptomics. Results show CEACAM6 overexpression, associations with genetic/epigenetic alterations, immune-cell correlations, and therapeutic potential linked to immune exclusion subtypes.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages14

Reading Time35 min

AccessFree to download

Introduction

Rationale and clinical need

Methods

Multi-omics datasets and analysis workflow

Results

CEACAM6 expression and prognostic associations

Genomic/epigenetic contributors

Immune microenvironment and spatial transcriptomics findings

Conclusion

Diagnostic accuracy and therapeutic targeting

Immunity, Inflammation and Disease ORIGINAL ARTICLE Integrative Omics Analysis Reveals the Potential Value of CEACAM6 in Pan‐Gastrointestinal Cancers Liying Jin1 | Changjuan Tao2 | Zhiyong Pan3 | Peng Zhang4,5 1Department of Gastroenterology, Xianju People's Hospital, Taizhou, China | 2Department of Radiation Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China | 3Department of Neurology, Yueyang People's Hospital, Yueyang, China | 4Department of Medical Oncology, Zhejiang Provincial People's Hospital, Hangzhou, China | 5Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China Correspondence: Peng Zhang ([zhangpeng@hmc.edu.cn](zhangpeng@hmc.edu.cn)) Received: 10 July 2024 | Revised: 24 November 2025 | Accepted: 5 January 2026 Funding: Medical Science and Technology Project of Zhejiang Province, Grant/Award Number: 2024KY047; Natural Science Foundation of Zhejiang Province, Grant/Award Number: Q24H160113 Keywords: CEACAM6 | pan‐gastrointestinal cancers | prognosis | tumor immune microenvironment ABSTRACT Objective: Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) is known as a cell adhesion receptor which could regulate proliferation and other signaling in cancer. The role of CEACAM6 in pan‐gastrointestinal cancers remains largely uncharacterized. This study employed multi‐omics bioinformatics to investigate the expression distribution, prognostic value, and immune function of CEACAM6 in these malignancies. Methods: Utilizing multi‐omics data from The Cancer Genome Atlas (TCGA), cBioPortal, GDSC2, TIMER2.0, and TISCH databases, we assessed the CEACAM6 expression and prognostic value across pan‐gastrointestinal cancers. Additionally, the potential role of CEACAM6 in the tumor immune microenvironment was explored using multi‐omics data, including spatial transcriptomics data. Results: Based on TCGA data, CEACAM6 was found to be overexpressed in pan‐gastrointestinal cancers. The CEACAM6 somatic copy number alterations, DNA methylation and mutation sites were identified as potential contributors to abnormal CEACAM6 expression. The CEACAM6 expression was significantly negatively associated with the abundance of CD4 + Th1 cells across pan‐gastrointestinal cancers. Furthermore, spatial transcriptomics data revealed that CEACAM6 expression was significant positively associated with malignant cells, while there was a negative correlation was observed with between CEACAM6 expression and plasma cells. Conclusion: CEACAM6 exhibits high diagnostic accuracy and tumor‐specific overexpression in pan‐gastrointestinal cancers. CEACAM6 could promote angiogenesis/metastasis and suppress anti‐tumor immunity. Spatially localized in tumors with immune cell exclusion, CEACAM6 correlates with poor survival and immune‐excluded subtypes, positioning it as a therapeutic target in precision immunotherapy for pan‐gastrointestinal cancers. | Liying Jin and Changjuan Tao contributed equally to this work. | | --- | | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
© 2026 The Author(s) . Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. | Immunity, Inflammation and Disease, 2026; 14:e70327 1 of 14 [https://doi.org/10.1002/iid3.70327](https://doi.org/10.1002/iid3.70327) 1 | Introduction Pan‐gastrointestinal cancers, comprising esophageal, gastric, and colorectal cancers, are among the most prevalent and fatal malignancies globally. Notably, colorectal cancer and gastric cancers rank among the top ten cancer types with the highest mortality rates worldwide [1] . In 2022, an estimated 1.9 million patients were newly diagnosed with col

FAQs

What was the main goal of the study on CEACAM6 in pan-gastrointestinal cancers?

To determine how CEACAM6 is expressed across pan-gastrointestinal cancers and whether it has prognostic value and functional links to the tumor immune microenvironment.

Which data sources and approaches were used to analyze CEACAM6?

Multi-omics bioinformatics was performed using datasets from TCGA and tools/databases including cBioPortal, GDSC2, TIMER2.0, and TISCH, with immune microenvironment exploration that includes spatial transcriptomics data.

What did the study find regarding CEACAM6 expression and its clinical relevance?

CEACAM6 was overexpressed in pan-gastrointestinal cancers, with potential contributions from copy number alterations, DNA methylation, and mutation sites, and it showed diagnostic accuracy alongside links to poor survival and immune-excluded subtypes.

Sep 22, 2026

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