Incidence and factors associated with central line-associated bloodstream infection in patients with chronic intestinal failure - Research article - 20-year retrolective cohort

Sep 29, 2026

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Type 3 intestinal failure (IF-3) is a chronic condition that often requires long-term outpatient intravenous supplementation via a central venous catheter, placing patients at risk for catheter-related infections such as central line-associated bloodstream infection (CLABSI). This 20-year retrospective cohort study evaluated CLABSI incidence and associated factors among IF-3 patients receiving OIS at a national tertiary referral center. Poisson regression identified variables linked to CLABSI, with results emphasizing clinical and psychosocial contributors to prevention.

LanguageEnglish

CategoryResearch & Report

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Pages16

Reading Time40 min

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Abstract

Background

Methodology

Results

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Introduction

OPEN ACCESS Citation: González-Salazar LE, Verdeja-Padilla PA, Reyes-Ramírez AL, Flores-López A, Castillo-Martínez L, Galindo-Fraga A, et al. (2026) Incidence and factors associated with central line-associated bloodstream infection in patients with chronic intestinal failure. A 20-year retrolective cohort. PLoS One 21(1): e0340064. [https://doi](https://doi). org/10.1371/journal.pone.0340064 Editor: Rodney Adam, Aga Khan University Hospital Nairobi, KENYA Received: March 10, 2025 Accepted: December 16, 2025 Published: January 6, 2026 Copyright: © 2026 González-Salazar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data availability statement: All relevant data are within the manuscript and its Supporting Information files. RESEARCH ARTICLE Incidence and factors associated with central line-associated bloodstream infection inpatients with chronic intestinal failure. A 20-year retrolective cohort Luis Eduardo González-Salazar1, Pedro Antonio Verdeja-Padilla2, Ana Luz Reyes-Ramírez1, Adriana Flores-López1, Lilia Castillo-Martínez1, Arturo Galindo-Fraga3, Alma Rosa Chávez-Ríos3,4, Martha Asunción Huertas-Jiménez5, Aurora Elizabeth Serralde-Zúñiga1* 1 Servicio de Nutriología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2 Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, UNAM, Mexico City, Mexico, 3 Subdirección de Epidemiología Hospitalaria y Control de la Calidad de la Atención Médica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4 Clínica de Catéteres Ambulatoria, Subdirección de Epidemiología Hospitalaria y Control dela Calidad de la Atención Médica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 5 Subdirección de Enfermería, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico * [aurora.serraldez@incmnsz.mx](aurora.serraldez@incmnsz.mx) Abstract Background Type 3 Intestinal Failure (IF-3) is a chronic condition in which patients may require long-term Outpatient Intravenous Supplementation (OIS) to maintain hydration and nutrition, they are susceptible to catheter-related infectious complications. The present study aimed to determine the incidence of factors associated with central lineassociated bloodstream infection (CLABSI) in patients with IF-3 on OIS. Methodology Retrolective cohort study of patients with IF-3 undergoing OIS treated at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, a national tertiary care and referral center in Mexico City, between 2004 and 2024. Sociodemographic, anthropometric, biochemical, clinical, and microbiological data, including isolated pathogens, were collected. Variables associated with CLABSI incidence were determined using Poisson regression analysis. Results Sixty patients were included, of which 31 (51 .7%) were female and 29 (48 .3%) were male. The mean age was 49.5 ± 18.1 years, and BMI was 19.8 ± 5.31kg/m2. The PLOS One | [https://doi.org/10.1371/journal.pone.0340064](https://doi.org/10.1371/journal.pone.0340064) January 6, 2026 1 / 16 Funding: The author(s) received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist. primary pathophysiological mechanism of IF-3 was short bowel syndrome (n = 23 (38 .3%)) . Twenty-seven (45%) patients developed CLABSI, resulting in 36 events over 27,200 catheter days, with an incidence rate of 1.323 per 1,000 catheter days. Fifty-seven pathogens were isolated, the most frequent being Gram-negative bacteria (52 .6%), specifically the Enterobacter cloacae complex (23 .3%) and Klebsiella oxytoca (16 .6%) . Patients

FAQs

What was the study objective regarding CLABSI in IF-3 patients?

To determine the incidence of factors associated with central line-associated bloodstream infection in patients with type 3 intestinal failure receiving outpatient intravenous supplementation.

How was the study conducted?

A 20-year retrospective cohort of IF-3 patients undergoing outpatient intravenous supplementation between 2004 and 2024, collecting sociodemographic, clinical, biochemical, and microbiological data.

Which factors were associated with higher CLABSI incidence?

Intestinal stomas showed a higher CLABSI incidence, and depression was associated with increased CLABSI incidence in the regression analysis.

Sep 29, 2026

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