Impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX - study

Sep 15, 2026

Background: Surgery after induction chemotherapy for locally advanced pancreatic cancer can entail drawbacks when curative resection is not feasible, leading to non-therapeutic laparotomy. Objective: Assess the incidence and oncological impact of non-therapeutic laparotomy in patients treated with induction (m)FOLFIRINOX. Methods: Retrospective international multicentre comparison of non-therapeutic laparotomy versus no surgery and versus resection. Results: No significant survival reduction versus non-surgical care; resection showed better outcomes.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages10

Reading Time25 min

AccessFree to download

Abstract

Background

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EUR Research Information Portal Impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX Published in: British Journal of Surgery Publication status and date: Published: 01/03/2024 DOI (link to publisher): 10.1093/bjs/znae033 Document Version Publisher's PDF, also known as Version of record Document License/Available under: CC BY Citation for the published version (APA): Theijse, R. T. , Stoop, T. F. , Janssen, Q. P. , Prakash, L. R. , Katz, M. H. G. , Doppenberg, D. , Tzeng, C. W. D. , Wei, A. C. , Zureikat, A. H. , Koerkamp, B. G. , & Besselink, M. G. (2024) . Impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX: Trans-Atlantic Pancreatic Surgery (TAPS) Consortium study. British Journal of Surgery, 111(3), Article znae033 . [https://doi.org/10.1093/bjs/znae033](https://doi.org/10.1093/bjs/znae033) Link to publication on the EUR Research Information Portal Terms and Conditions of Use Except as permitted by the applicable copyright law, you may not reproduce or make this material available to any third party without the prior written permission from the copyright holder(s) . Copyright law allows the following uses of this material without prior permission: • you may download, save and print a copy of this material for your personal use only; • you may share the EUR portal link to this material. In case the material is published with an open access license (e.g. a Creative Commons (CC) license), other uses may be allowed. Please check the terms and conditions of the specific license. Take-down policy If you believe that this material infringes your copyright and/or any other intellectual property rights, you may request its removal by contacting us at the following email address: [openaccess.library@eur.nl. Please](openaccess.library@eur.nl. Please) provide us with all the relevant information, including the reasons why you believe any of your rights have been infringed. In case of a legitimate complaint, we will make the material inaccessible and/or remove it from the website. BJS, 2024, znae033 [https://doi.org/10.1093/bjs/znae033](https://doi.org/10.1093/bjs/znae033) Original Article Impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX: Trans-Atlantic Pancreatic Surgery (TAPS) Consortium study Rutger T. Theijse1,2, Thomas F. Stoop1,2,3 , Quisette P. Janssen4, Laura R. Prakash5, Matthew H. G. Katz5 , Deesje Doppenberg1,2, Ching-Wei D. Tzeng5, Alice C. Wei6 , Amer H. Zureikat7, Bas Groot Koerkamp4 and Marc G. Besselink1,2,* on behalf of the Trans-Atlantic Pancreatic Surgery (TAPS) Consortium 1Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands 2Cancer Center Amsterdam, Amsterdam, The Netherlands 3Division of Surgical Oncology, Department of Surgery, University of Colorado, Aurora, Colorado, USA 4Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands 5Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 6Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA 7Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA *Correspondence to: Marc G. Besselink, Department of Surgery, Amsterdam UMC, location University of Amsterdam, De Boelelaan 1117 (ZH-7F18), Amsterdam, 1081 HV, The Netherlands ([e-mail: m.g.besselink@amsterdamUMC.nl](e-mail: m.g.besselink@amsterdamUMC.nl)) Presented to the following international congresses: Pancreas Club, Chicago, IL, USA, May 2023; and Society for Surgery of the Alimentary Tract (SSAT), Chicago, IL, USA, May 2023. Abstract Background: Surgery in selected patients with locally advanced pancreatic

FAQs

What clinical problem does the study address?

The study evaluates oncological consequences when patients with locally advanced pancreatic cancer undergo induction (m)FOLFIRINOX but end up with a non-therapeutic laparotomy because curative resection is not possible.

How was the research conducted and what groups were compared?

A retrospective international multicentre design compared patients receiving non-therapeutic laparotomy with patients not undergoing surgery and with patients undergoing resection.

What were the key findings regarding survival?

Non-therapeutic laparotomy was not associated with reduced overall survival compared with no surgery, while patients who underwent resection had longer overall survival and higher 5-year survival rates.

Sep 15, 2026

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