Human Papillomavirus (HPV)-Associated Cancers Among Hispanic Males in the United States - Late-Stage Diagnosis by Country of Origin

Sep 24, 2026

Uploaded by Mary Man

Study evaluates differences in late-stage diagnosis of human papillomavirus (HPV)-associated cancers among Hispanic male subgroups in the United States, focusing on oropharyngeal, anorectal, and penile cancers. Using a population-based retrospective cohort from 2005–2016 NAACCR data (n=9242), multivariable logistic regression assessed factors linked to late-stage presentation. Results show subgroup-specific patterns tied to country of origin and insurance coverage, including higher penile cancer odds and insurance-associated late-stage diagnoses.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Abstract

Introduction

HPV burden and prevention in males

Vaccination uptake and disparities

Objective

Methods

Results

Conclusion

Keywords

| Human Papillomavirus (HPV)-Associated Cancers Among Hispanic Males in the United States: Late-Stage Diagnosis by Country of Origin | Cancer Control Volume 30: 1–11
© The Author(s) 2023
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[DOI: 10.1177/10732748231218088](DOI: 10.1177/10732748231218088)[ ](DOI: 10.1177/10732748231218088)[journals.sagepub.com/home/ccx](journals.sagepub.com/home/ccx)

| | --- | --- | | Seiichi Villalona 1,2 􀀁, Satsuki Villalona3, Daisy Reinoso4, Simone Sukhdeo4, Antoinette M. Stroup5,6, and Jeanne M. Ferrante6,7
Abstract
Introduction: The epidemiology of human papillomavirus (HPV)-associated cancers has changed since the development of the multivalent vaccine. This is evidenced by the decline in incidence of cervical cancers in the post-vaccine era. By contrast, studies have reported the rise in incidence of these cancers in males. Though little is known regarding HPV-associated cancers in males, Hispanic males have been largely excluded from research on these cancers.
Objective: The purpose of this study was to examine the differences in late-stage diagnosis of HPV-associated cancers (oropharyngeal, anorectal, or penile) among subgroups of Hispanic males in the U.S.
Methods: We performed a population-based retrospective cohort study using the 2005–2016 North American Association of Central Cancer Registries Cancer in North America Deluxe data ﬁle (n = 9242). Multivariable logistic regression modeling was used in studying late-stage diagnosis.
Results: There were no differences in late-stage diagnosis of oropharyngeal cancer between Hispanic subgroups. Higher odds of late-stage penile cancers were observed among Mexican and Puerto Rican males relative to European Spanish males. Lower odds of late-stage anorectal cancers were observed among Central or South American and Puerto Rican males. Having Medicaid or no insurance were associated with late-stage diagnosis for all cancers.
Conclusion: Certain subgroups of Hispanic males have higher odds of late-stage HPV-associated cancer diagnosis based on country of origin and insurance status. These ﬁndings call for improved efforts to increase HPV vaccination, particularly among these subgroups of Hispanic males. Efforts to improve health care access and early detection from health care providers are also needed.
Keywords
human papillomavirus, Hispanic, males, late-stage cancer | | | 1 Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 2Hospital of the University of Pennsylvania, Philadelphia, PA, USA
3The College of New Jersey, Ewing, NJ, USA
4Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
5Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA 6Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
7Department of Family Medicine and Community Health, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Corresponding Author:
Seiichi Villalona, Hospital of the University of Pennsylvania, 3701 Market St., Philadelphia, PA 19104, USA.
Email: Seiichi.Vi[llalona@pennmedicine.upenn.edu](llalona@pennmedicine.upenn.edu) | | Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/4.0/](creativecommons.org/licenses/by/4.0/)) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as speciﬁed on the SAGE and Open Access pages ([https://us.sagepub.com/en-us/nam/](https://us.sagepub.com/en-us/nam/) open-access-at-sage). Received May 15, 2023. Received revised October 9, 2023. Accepted for publication November 7, 2023. Introduction In the United States, human papillomavirus (HPV) is the most common sexually transmitted

FAQs

What was the objective of this study?

To examine differences in late-stage diagnosis of HPV-associated cancers (oropharyngeal, anorectal, or penile) among subgroups of Hispanic males in the U.S.

How were late-stage diagnoses analyzed?

A population-based retrospective cohort study used NAACCR Cancer in North America Deluxe data from 2005–2016 (n=9242), with multivariable logistic regression modeling to study late-stage diagnosis.

Which factors were associated with late-stage HPV-associated cancer diagnosis?

Certain Hispanic male subgroups showed different odds based on country of origin, and having Medicaid or no insurance was associated with late-stage diagnosis across cancers.

Sep 24, 2026

Uploaded by Mary Man