HISPANIC/LATINO(A) AGING WITH HIV - INSIGHTS FROM THE MWCCS COHORT

Q: How was frailty defined and categorized?

Frailty was defined using the Fried Frailty Phenotype, with a score of 3/5 or higher indicating frailty.

Q: What were the key sex-specific findings regarding CVD risk and frailty?

Among men, Hispanic/Latino participants had lower odds of intermediate and high CVD risk but higher odds of frailty than non-Hispanic/Latino Whites; among women, ethnicity-related differences were not significant for frailty or CVD risk.

Sep 29, 2026

Uploaded by Rainbow Cat

Hispanic/Latino individuals living with HIV remain understudied yet show significant health disparities compared with non-Hispanic/Latino groups. The MWCCS analysis evaluated frailty and 10-year cardiovascular disease (CVD) risk among Hispanic/Latino and non-Hispanic/Latino White adults aged 40+. Frailty used the Fried Frailty Phenotype (score ≥3/5), while CVD risk was grouped as low, borderline, intermediate, or high using model-based estimates and adjusted odds ratios with 95% confidence intervals.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages2

Reading Time5 min

AccessFree to download

Background

Study Design and Measures

Frailty Definition

CVD Risk Categorization

Results

Sex-Stratified Findings

Interpretation and Implications

Innovation in Aging, 2025, Vol. 9, No. S2 1235 Abstract citation ID: igaf122.4130 HISPANIC/LATINO(A) AGING WITH HIV: INSIGHTS FROM THE MWCCS COHORT Mirza Ishrat Noor1, Mark Kuniholm1, Allison Appleton1, Jessica Islam2, Marlene Camacho-Rivera3, Gypsyamber D’Souza4, Deborah Gustafson3, and Elizabeth Vásquez1, 1. University at Albany (SUNY), Albany, New York, United States, 2. H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States, 3. SUNY Downstate Health Sciences University, Brooklyn, New York, United States, 4. Johns Hopkins University, Baltimore, Maryland, United States Hispanic/Latino (H/L) individuals living with HIV are an understudied and diverse population with significant health disparities compared to non-H/L individuals. We examined frailty and cardiovascular disease (CVD) risk among H/L and non-H/L White adults aged ≥40 years in the MACS/WIHS Combined Cohort Study (MWCCS) . The sample included 621 H/L and 1,293 non-H/L White participants. Frailty was defined using the Fried Frailty Phenotype (FFP), with a score ≥3/5 indicating frailty. Ten-year CVD risk was categorized as low (< 5%), borderline (5–7.4%), intermediate (7.5–19.9%), or high (≥20%). Adjusted odds ratios (aOR) and 95% confidence intervals (CI) assessed associations between ethnicity and outcomes, with models stratified by sex and adjusted for HIV status, age, education, BMI, depression, diabetes, and hypertension. H/L participants were more likely to be women (53.6% vs. 15.9%), frail (22.5% vs. 11.8%), and living with HIV (73.3% vs. 50.7%), but less likely to have hypertension (46.9% vs. 66.3%) or high CVD risk (7.5% vs. 18.4%) . Among men, H/L participants had significantly lower odds of intermediate (aOR: 0.32, CI: 0.18–0.57) and high (aOR: 0.20, CI: 0.09–0.45) CVD risk but higher odds of frailty (aOR: 3.54, CI: 1.65–7.58) than non-H/L Whites. Among 1236 Innovation in Aging, 2025, Vol. 9, No. S2 women, no significant differences were observed in frailty or CVD risk by ethnicity. Despite lower CVD risk, H/L men had higher frailty, suggesting potential sex-specific disparities that require further investigation.

FAQs

What populations were compared in the MWCCS cohort analysis?

Hispanic/Latino and non-Hispanic/Latino White adults aged 40+ living with or without HIV were compared within the MACS/WIHS Combined Cohort Study (MWCCS).

How was frailty defined and categorized?

Frailty was defined using the Fried Frailty Phenotype, with a score of 3/5 or higher indicating frailty.

What were the key sex-specific findings regarding CVD risk and frailty?

Among men, Hispanic/Latino participants had lower odds of intermediate and high CVD risk but higher odds of frailty than non-Hispanic/Latino Whites; among women, ethnicity-related differences were not significant for frailty or CVD risk.

Sep 29, 2026

Uploaded by Rainbow Cat