Higher microRNA-221 and lower microRNA-451 expression are associated with poor prognosis in patients with thyroid papillary carcinoma

Q: What relationship does the study assess between microRNAs and prognosis?

The study analyzes how serum microRNA-221 and microRNA-451 expression relates to pathological features and prognosis in patients with thyroid papillary carcinoma.

Q: How were microRNA levels measured and compared?

Relative expression levels of microRNA-221 and microRNA-451 were compared between the thyroid papillary carcinoma group (before treatment) and healthy controls, and also across pathological characteristics.

Q: Which microRNA pattern is linked with aggressive features and poor prognosis?

Higher microRNA-221 expression and lower microRNA-451 expression are associated with extracapsular invasion, lymphatic metastasis, and poor prognosis.

Sep 21, 2026

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Serum microRNA-221 expression and microRNA-451 expression are examined in patients with thyroid papillary carcinoma to clarify their association with pathological features and prognosis. A cross-sectional study includes 120 patients and 120 healthy volunteers, comparing relative circulating expression before treatment. MicroRNA-221 is higher, while microRNA-451 is lower in carcinoma patients, especially when extracapsular invasion, lymphatic metastasis, and poor prognosis are present. Multivariate logistic regression links aggressive morphological features with microRNA-221 high and microRNA-451 low.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages7

Reading Time18 min

AccessFree to download

Abstract

Background

Methods

Results

Conclusions

Keywords

Introduction

Materials and Methods

Results

DEL SISTEMA SANITARIO DE NAVARRA An Sist Sanit Navar 2023; 47(2): e1086 [https://doi.org/10.23938/ASSN.1086](https://doi.org/10.23938/ASSN.1086) eISSN: 2340-3527 • ISSN: 1137-6627 [https://recyt.fecyt.es/index.php/ASSN/](https://recyt.fecyt.es/index.php/ASSN/) ORIGINAL ARTICLES Higher microRNA-221 and lower microRNA-451 expression are associated with poor prognosis in patients with thyroid papillary carcinoma La expresión aumentada de microRNA-221 y disminuida de microRNA-451 serelaciona con mal pronóstico en pacientes con carcinoma papilar de tiroides Jiawei Wu, Weimin Sun, Jingyao Shen, Liping Hu | ABSTRACT | RESUMEN | | --- | --- | | Background. To analyze the relationship between serum mi- | Fundamento. Analizar la relación entre la expresión sérica | | croRNA-221 and microRNA-451 relative expression and the | relativa de microRNA-221 y microRNA-451 y las características | | pathological features and prognosis of patients with thyroid | patológicas y el pronóstico de pacientes con carcinoma papilar | | papillary carcinoma. | de tiroides. | | Methods. Cross-sectional study that included 120 patients with | Metodología. Estudio transversal que incluyó 120 pacientes | | papillary thyroid cancer treated at the hospital and 120 healthy | con carcinoma papilar de tiroides tratados en el hospital y 120 | | volunteers selected as the control group who underwent physical | voluntarios sanos que se sometieron a un examen físico en el | | examination at the same centre. The relative expression levels of | mismo centro (grupo control). Los niveles de expresión relati- | | microRNA-221 and microRNA-451 were compared between the | va de microRNA-221 y microRNA-451 se compararon entre el | | thyroid papillary carcinoma group (prior to treatment) and the control group. Additionally, microRNA-221 and microRNA-451 | grupo con carcinoma papilar de tiroides (previo al inicio del tratamiento) y el grupo control, así como entre pacientes con | | expression levels were analyzed in patients with papillary thy- | diferentes características patológicas. | | roid carcinoma across different pathological characteristics. | Resultados. Los niveles de microRNA-221 estaban más ele- | | Results. Serum microRNA-221 relative levels were significant- | vados (p<0,001) en el grupo con carcinoma papilar de tiroi- | | ly higher (p<0.001) in the papillary carcinoma group compared | des, mientras los niveles de microRNA-451 fueron mayores | | to the control group, while microRNA-451 levels were higher in | en el grupo control (p<0,001). Los niveles de microRNA-221 | | the control group (p<0.001). In the papillary carcinoma group, | eran más altos en pacientes con carcinoma papilar de tiroi- | | microRNA-221 expression was significantly higher inpatients with | des con invasión extracapsular (p<0,001), metástasis linfáti- | | extracapsular invasion (p<0.001), lymphatic metastasis (p=0.003), | cas (p=0,003) y mal pronóstico (p<0,001). Los niveles de mi- | | and poor prognosis (p<0.001). Conversely, microRNA-451 expres- | croRNA-451 fueron significativamente menores (p<0,001) en | | sion was significantly lower (p<0.001) in patients with extracap- | pacientes con invasión extracapsular, metástasis linfáticas | | sular invasion, lymphatic metastasis, and poor prognosis. In the | y mal pronóstico. Tanto la invasión extracapsular como las | | multivariate logistic regression analysis, morphological features | metástasis linfáticas, características sugestivas de un com- | | suggestive of an aggressive clinical behavior (extracapsular invasion and lymphatic metastasis) were related to high expression of | portamiento clínico agresivo, se asociaron a alta expresiónde microRNA-221 y a baja expresión de microRNA-451 en pa- | | microRNA-221 and low expression of microRNA-451 in patients with thyroid papillary carcinoma (p<0.001). | cientes con carcinoma papilar de tiroides (regresión logísticamúltiple; p<0,001). | | Conclusions. Serum microRNA-221 and microRNA

FAQs

What relationship does the study assess between microRNAs and prognosis?

The study analyzes how serum microRNA-221 and microRNA-451 expression relates to pathological features and prognosis in patients with thyroid papillary carcinoma.

How were microRNA levels measured and compared?

Relative expression levels of microRNA-221 and microRNA-451 were compared between the thyroid papillary carcinoma group (before treatment) and healthy controls, and also across pathological characteristics.

Which microRNA pattern is linked with aggressive features and poor prognosis?

Higher microRNA-221 expression and lower microRNA-451 expression are associated with extracapsular invasion, lymphatic metastasis, and poor prognosis.

Sep 21, 2026

Upload by Levi