High-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix - a case report

Sep 21, 2026

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High-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix is described as a rare scenario within multiple primary malignant neoplasms. The case involves a 47-year-old woman presenting with irregular vaginal bleeding and diagnostic findings suggesting HPV 16 infection with atypical SCC cells. After comprehensive staging with imaging and pathology, the patient underwent laparoscopic radical hysterectomy and related procedures, followed by postoperative chemotherapy leading to complete remission. Genetic testing identified BRCA2 mutations, and PARP inhibitors were used for maintenance therapy.

LanguageEnglish

CategoryResearch & Report

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Pages8

Reading Time20 min

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Introduction

Case report

TYPE Case Report PUBLISHED 07 March 2024 DOI 10.3389/fonc.2024.1298109 OPEN ACCESS EDITED BY Sophia George, University of Miami, United States REVIEWED BY Federica Perelli, Azienda USL Toscana Centro, Italy Dilyara Kaidarova, Kazakh Institute of Oncology and Radiology, Kazakhstan *CORRESPONDENCE Lianli He [1744122878@qq.com](1744122878@qq.com) †These authors share ﬁrst authorship RECEIVED 21 September 2023 ACCEPTED 29 January 2024 PUBLISHED 07 March 2024 CITATION Wu M, Zhang W, He L, Zhu Y, Jiang X, Zhang L, Yuan X and Li T (2024) High-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix: a case report. Front. Oncol. 14:1298109 . doi: 10.3389/fonc.2024.1298109 COPYRIGHT © 2024 Wu, Zhang, He, Zhu, Jiang, Zhang, Yuan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. High-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix: a case report Maoyuan Wu 1†, Wenwen Zhang 1†, Lianli He 2*, Ye Zhu 2, Xiaoling Jiang 2, Lixia Zhang 2, Xiwei Yuan 3 and Tingchao Li 4 1 Department of Gynecology and Obstetrics, The Third Afﬁliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, China, 2 Department of Gynecology, The Third Afﬁliated Hospital of Zunyi Medical University (The First People ’s Hospital of Zunyi), Zunyi, Guizhou, China, 3 Department of Imaging, The Third Afﬁliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, China, 4 Department of Pathology, The Third Afﬁliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, China Multiple primary malignant neoplasms are a rare gynecologic malignancy; particularly, cases originating from the heterologous organs, such as the ovary and cervix. Here, we report a case of two primary malignant neoplasms in a patient who had undergone laparoscopic radical hysterectomy + bilateral salpingo-oophorectomy + pelvic lymph node dissection + para-aortic lymphadenectomy + appendectomy + omentectomy + metastasectomy under general anesthesia. The patient experienced complete remission after six courses of postoperative chemotherapy with a standard Taxol and Carboplatin regimen. Genetic testing was performed to detect BRCA2 mutations, and poly (ADP-ribose) polymerase (PARP) inhibitors were used for maintenance therapy. KEYWORDS case report, multiple primary malignant neoplasms, cervical cancer, ovarian cancer, high-grade serous papillary carcinoma 1 Introduction Multiple primary malignant neoplasms (MPMN) were ﬁrst described by Billroth et al. in 1889 (1) . Many clinical cases of MPMN have been reported since. Most patients have metachronous MPMN as MPMN occurrences are rarely synchronous. MPMNs originating from the female reproductive system account for 1–2% of the cases of gynecologic malignant neoplasms. Among these cases, the most prevalent ones, accounting for approximately 50–70% of cases, have synchronous ovarian and endometrial cancers arising from homologous tissues (2, 3) . However, cases of malignant neoplasms synchronously arising from the cervix and ovary are extremely rare. Frontiers in Oncology 01 [frontiersin.org](frontiersin.org) Here, we report a case of high-grade serous papillary carcinoma (HGSOC) of the ovary combined with nonkeratinizing squamous cell carcinoma (SCC) of the cervix with multiple metastases from the HGSOC. 2 Case report A 47-year-old woman was admitted to the hospital because of irreg

FAQs

What makes the reported condition clinically rare?

The report highlights synchronously combined malignancies arising from the cervix and ovary, which are described as extremely rare compared with other multiple primary malignant neoplasm patterns.

What diagnostic findings supported the suspicion of cervical and ovarian cancers?

ThinPrep cytology suggested atypical SCC cells and HPV 16, cervical biopsy indicated grade-III cervical intraepithelial neoplasia, and colposcopy plus imaging (MRI and PET-CT) showed cervical lesions and suspected metastatic masses.

What treatment and follow-up strategy was used after surgery?

The patient received postoperative chemotherapy with a Taxol and Carboplatin regimen to achieve complete remission, followed by genetic testing for BRCA2 mutations and maintenance therapy with PARP inhibitors.

Sep 21, 2026

Uploaded by Finn