Grip Strength as a Mediator Linking Motoric Cognitive Risk Syndrome to Instrumental Activities of Daily Living - Article Abstract

Sep 29, 2026

Upload by Ben

Motoric cognitive risk syndrome (MCR) is a preclinical state marked by gait impairment and cognitive complaints, appearing before dementia. This cross-sectional study examined how MCR relates to instrumental activities of daily living (IADL) through grip strength in 204 Taiwanese adults aged 65+. Participants were classified as robust or MCR based on timed-up-and-go performance and subjective cognitive complaints. MCR prevalence was 25%. IADL scores correlated negatively with MCR, and grip strength partially mediated the effect, accounting for 33% of the total impact. Results support monitoring grip strength with gait and cognitive status for aging.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Abstract

Study design and participants

Measurement of MCR and classification

Statistical mediation analysis

Key findings and implications

Innovation in Aging, 2025, Vol. 9, No. S2 1179 Abstract citation ID: igaf122.3949 GRIP STRENGTH AS A MEDIATOR LINKING MOTORIC COGNITIVE RISK SYNDROME TO INSTRUMENTAL ACTIVITIES OF DAILY LIVING Wan-Yun Chou, and Su-I Hou, University of Central Florida, Orlando, Florida, United States, Motoric cognitive risk syndrome (MCR) represents a preclinical condition characterized by the simultaneous presence of gait impairment and cognitive complaints, typically manifesting before dementia onset. This study explores the complex mediating relationships between MCR, instrumental activities of daily living (IADL), and grip strength among Taiwanese older adults . The cross-sectional study analyzed 204 community-dwelling adults aged 65 and older who participated in annual health screenings between March 2021 and November 2022. Participants were categorized as either robust or having MCR, with MCR diagnosed when individuals scored below 1.5 standard deviations of age- and sex-matched norms on timed-up-and-go speed assessments while experiencing subjective cognitive complaints. Bootstrap analysis, with 5000 resamples, was employed to investigate how grip strength mediates the relationship between MCR and daily functioning. The prevalence of MCR reached 25% among participants. Results demonstrated a significant negative correlation between IADL score and MCR presence, with grip strength serving as a crucial mediating factor (β=-1.1055, p = 0.003). Bootstrap analysis confirmed the partial mediating effect of grip strength, explaining 33% of the total effect of MCR presence on IADL score. These findings underscore the critical importance of monitoring grip strength alongside gait speed and cognitive health to preserve daily activity function in aging populations. Understanding MCR’s underlying mechanisms could facilitate early dementia detection and prevention strategies. The research highlights the necessity of monitoring both grip strength and MCR in older adults. However, the convenience sampling methodology may limit generalizability, necessitating further investigation into grip strength’s impact on MCR-IADL relationships for broader clinical applications.

FAQs

How was motoric cognitive risk syndrome (MCR) defined in the study?

MCR was diagnosed when individuals scored below 1.5 standard deviations from age- and sex-matched norms on timed-up-and-go speed assessments while reporting subjective cognitive complaints.

What role did grip strength play between MCR and daily functioning?

Grip strength partially mediated the relationship between MCR presence and IADL score, indicating grip strength is a crucial factor linking motoric-cognitive risk to everyday functioning.

What were the study’s main results regarding IADL and MCR?

IADL score showed a significant negative correlation with MCR presence, and the mediation model explained 33% of the total effect of MCR on IADL. The reported effect was statistically significant (β=-1.1055, p=0.003).

Sep 29, 2026

Upload by Ben