Glyco-platelets with controlled morphologies via crystallization-driven self-assembly and their shape-dependent interplay with macrophages

Sep 21, 2026

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The study addresses controlled preparation of 2D biological and biodegradable nanostructures, focusing on PLLA-based diblock glycopolymers assembled by crystallization-driven self-assembly (CDSA). Careful selection of building block structures and assembly conditions enables formation of 1D glyco-cylinders and 2D diamond-shaped glyco-platelets with either solid or hollow cores, with the latter reported as previously unavailable. Shape- and dimensionality-dependent macrophage activation reveals a clear size effect compared with 1D analogues, supporting potential immunological applications.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages9

Reading Time23 min

AccessFree to download

Abstract

Nanostructure design via CDSA

Formation of 1D and 2D glyco-structures

Macrophage activation and size effects

University of Birmingham Glyco-platelets with controlled morphologies via crystallization-driven self-assembly and their shapedependent interplay with macrophages Li, Zhen; Zhang, Yufei; Wu, Libin; Yu, Wei; Wilks, Thomas R; Dove, Andrew P; Ding, HongMing; O'Reilly, Rachel K; Chen, Guosong; Jiang, Ming DOI: 10.1021/acsmacrolett.9b00221 License: Other (please specify with Rights Statement) Document Version Peer reviewed version Citation for published version (Harvard): Li, Z, Zhang, Y, Wu, L, Yu, W, Wilks, TR, Dove, AP, Ding, H-M, O'Reilly, RK, Chen, G & Jiang, M 2019, 'Glycoplatelets with controlled morphologies via crystallization-driven self-assembly and their shape-dependent interplay with macrophages', ACS Macro Letters, vol. 8, no. 5, pp. 596-602. [https://doi.org/10.1021/acsmacrolett.9b00221](https://doi.org/10.1021/acsmacrolett.9b00221) Link to publication on Research at Birmingham portal Publisher Rights Statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://doi.org/10.1021/acsmacrolett.9b00221](https://doi.org/10.1021/acsmacrolett.9b00221) General rights Unless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or the copyright holders. The express permission of the copyright holder must be obtained for any use of this material other than for purposes permitted by law. •Users may freely distribute the URL that is used to identify this publication. •Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research. •User may use extracts from the document in line with the concept of ‘fair dealing’ under the Copyright, Designs and Patents Act 1988 (?) •Users may not further distribute the material nor use it for the purposes of commercial gain. Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive. If you believe that this is the case for this document, [please contact UBIRA@lists.bham.ac.uk](please contact UBIRA@lists.bham.ac.uk) providing details and we will remove access to the work immediately and investigate. Download date: 21. Sep. 2026 Zhen Li,1 Yufei Zhang,1 Libin Wu,1 Wei Yu,2 Andrew P. Dove,3 Hong-ming Ding,4* Rachel K. O’Reilly,3* Guosong Chen,1* Jiang Ming1. 1The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China. 2Department of Chemistry, The University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom. 3School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. 4Center for Soft Condensed Matter Physics and Interdisciplinary Research, School of Physical Science and Technology, Soochow University, Suzhou 215006, China. ABSTRACT: Two-dimensional (2D) materials are of great significance to the materials community for their high surface area and controllable surface properties. However, controlled preparation of 2D structures with biological functions and biodegradable features is considerably hard. In this work, we demonstrate that, by careful selection of building block structures and assembly conditions, the above obstacle can be overcome partially by crystallization-driven self-assembly (CDSA) from PLLA-based diblock glycopolymers. 1D glyco-cylinders and 2D d

FAQs

What strategy enables the controlled assembly of the glyco-structures?

The work uses crystallization-driven self-assembly (CDSA) from PLLA-based diblock glycopolymers, with careful selection of building block structures and assembly conditions.

What glyco-structures are achieved in the study?

The researchers obtain 1D glyco-cylinders and 2D diamond-shaped glyco-platelets with solid or hollow cores.

How do the glyco-platelets influence macrophage behavior?

The 2D glyco-platelets demonstrate strong macrophage activation efficiency with a clear size effect compared with their 1D counterparts, indicating potential immunological applications.

Sep 21, 2026

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