Global research trends on the relationship between IBD and CRC - a bibliometric analysis from 2000 to 2023

Sep 21, 2026

Uploaded by Hazel

Objective, a bibliometric analysis of research articles exploring the relationship between inflammatory bowel disease (IBD) and colorectal cancer (CRC) from 2000 to 2023, using CiteSpace to summarize research status, hotspots, and trends, and to present results visually. Methods: English articles were retrieved from the Web of Science Core Collection and analyzed via cooperation, clustering, co-citation, and burst detection. Results: 4,239 articles were included; the USA led in publications; Mayo Clinic and Harvard University were most active; CRC was the most common keyword. Conclusion: Current emphasis centers on gut microbiota and oxidative stress, with implications for endoscopic monitoring and future therapeutic development.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages14

Reading Time35 min

AccessFree to download

Abstract

Introduction

Background: CRC burden and projections

IBD definitions and clinical distinctions

Link between IBD and CRC: inflammation, oxidative stress, microbiota

Research gap and purpose of the bibliometric study

Zhang et al. Journal of Health, Population and Nutrition (2024) 43:83 [https://doi.org/10.1186/s41043-024-00577-5](https://doi.org/10.1186/s41043-024-00577-5) Journal of Health, Population and Nutrition RESEARCH Open Access Global research trends on the relationship between IBD and CRC: a bibliometric analysis from 2000 to 2023 Hao Zhang 1†, Huiru Xin2†, Mengqi Zhao3†, Chenyang Bi 1, Yafei Xiao 1, Yifan Li 1 and Changjiang Qin 1* Abstract Objective This study aimed to conduct a bibliometric analysis of research articles on the relationship between inflammatory bowel disease (IBD) and colorectal cancer (CRC) using CiteSpace to summarize the current research status, hotspots, and trends in this field and present the results visually. Method Research articles on the relationship between IBD and CRC published from 2000 to 2023 and in English were selected from the Web of Science Core Collection (Woscc) database. The articles were downloaded as “full record and references”. CiteSpace was used to conduct cooperative, cluster, co-citation, and burst analyses. Results The literature search revealed 4244 articles; of which, 5 duplicates were removed, resulting in the inclusion of 4239 articles in this study. The United States of America had the highest number of publications, with Mayo Clinic and Harvard University being the most active institutions, and Bas Oldenburg being the most active author. Collaboration among core authors was inadequate. JA Eaden was the most cited author, and CRC was the most common keyword. Burst analysis indicated that Sun Yat-sen University might be one of the institutions with a large contribution to this research field in the future. Cluster analysis showed that earlier research focused more on microsatellite instability, whereas “gut microbiota” and “oxidative stress” are considered current research hotspots and trends. Conclusion At present, the primary focus areas of research are “gut microbiota” and “oxidative stress”. With the improvement of healthcare policies and standards, regular endoscopic monitoring of patients with IBD has become an indispensable diagnostic and therapeutic practice. More drugs will be developed to reduce the risk of progression from IBD to CRC. The findings ofthis study provide valuable insights into the relationship between IBD and CRC for researchers in the same field. Keywords IBD, CRC, Bibliometric, CiteSpace, WoSCC †Hao Zhang, Huiru Xin and Mengqi Zhao contributed equally to this work. *Correspondence: Changjiang Qin [hhyyqcj@126.com](hhyyqcj@126.com) 1Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China 2Department of Cardiothoracic Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China 3Department of Gastroenterology, Huaihe Hospital of Henan University, Kaifeng 475000, China © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ([http://creativecommons.org/publicdomain/zero/1.0/](http://creativecommons.org/publicdomain/zero/1.0/)) applies to the data made available in this article, unless otherw

FAQs

What is the objective of this study on IBD and CRC?

To conduct a bibliometric analysis of research on the IBD–CRC relationship from 2000 to 2023, summarizing research status, hotspots, and trends using CiteSpace and presenting findings visually.

How were the research articles selected and analyzed?

English research articles from 2000 to 2023 were selected from the Web of Science Core Collection, downloaded as full records and references, and analyzed in CiteSpace using cooperation, cluster, co-citation, and burst analyses.

What do the results indicate about current research hotspots?

Gut microbiota and oxidative stress are identified as current hotspots and trends, while earlier work focused more on microsatellite instability.

Sep 21, 2026

Uploaded by Hazel