Global Research Trends in the Links between Periodontal Disease and Cancer - A Bibliometric Analysis

Sep 21, 2026

Uploaded by Miles

Periodontal disease and cancer are widespread conditions with major effects on individuals and society. Research suggests a meaningful connection between them, motivating a bibliometric study of publications from 2014–2023. Using the Thomson Reuters Web of Science Core Collection database, the analysis extracted author, affiliation, publication date, journal, country, citation counts, keywords, and H-index data. Among 253 articles, outputs and citations increased, highlighting leading authors, institutions, and countries/regions, while clustered themes emphasized microbiome-driven carcinogenesis and inflammation.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages15

Reading Time38 min

AccessFree to download

Introduction

Epidemiology and relevance of periodontal disease and cancer

Biological mechanisms linking periodontal disease and cancer

Abstract

Scope and database

Methods and metrics

Key findings and thematic clusters

Keywords

Core keyword set

pathogens Review Global Research Trends in the Links between Periodontal Disease and Cancer: A Bibliometric Analysis Suh-Woan Hu 1,2, Jaw-Ji Yang 1 and Yuh-Yih Lin 1,2,3, * Citation: Hu, S.-W.; Yang, J.-J.; Lin, Y.-Y. Global Research Trends in the Links between Periodontal Disease and Cancer: A Bibliometric Analysis. Pathogens 2024, 13, 789. [https://](https://)[ ](https://)[doi.org/10.3390/pathogens13090789](doi.org/10.3390/pathogens13090789) Academic Editors: Milena Radunovicand Natalia Di Pietro Received: 28 July 2024 Revised: 28 August 2024 Accepted: 11 September 2024 Published: 12 September 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 Institute of Oral Sciences, College of Oral Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; [suhwoan@csmu.edu.tw](suhwoan@csmu.edu.tw) (S.-W.H.); [jjyang@csmu.edu.tw](jjyang@csmu.edu.tw) (J.-J.Y.) 2 Department of Stomatology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan 3 School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung 40201, Taiwan * [Correspondence: yuhyih@csmu.edu.tw](Correspondence: yuhyih@csmu.edu.tw); Tel.: +886-4-2471-8668 (ext. 55515) Abstract: Both periodontal disease and cancer are prevalent conditions with significant impactson individuals and society. Extensive research has suggested a potential link between these two diseases. This study conducted a bibliometric analysis using the Thomson Reuters Web of Science Core Collection database, focusing on publications from 2014 to 2023 . The analysis included data extraction and examination of authors, affiliations, publication dates, journals, countries, citation counts, keywords, and the H-index. A total of 253 relevant articles were identified, showing an increasing trend in both publications and citations over the years. The analysis highlighted the most productive authors, institutions, and countries/regions, with Michaud DS and Abnet CC leading in the number of publications. Highly cited articles emphasized the role of specific oral microbiota, particularly F. nucleatum and P. gingivalis, in various cancers, suggesting their potential as diagnostic markers and therapeutic targets. Four key thematic clusters emerged from the keyword analysis: the broader health implications of periodontal disease, the microbiome’s role in carcinogenesis, inflammation, and specific bacteria in cancer, and epidemiological methods in studying the disease– cancer association. This bibliometric analysis underscores the growing interest in the connection between periodontal disease and cancer. Future research should adopt interdisciplinary approaches, focus on large-scale microbiome studies and longitudinal research to understand the systemic effects of periodontal disease, identify cancer-associated bacterial profiles, and investigate the molecular mechanisms of bacterial carcinogenesis. Additionally, public health interventions aimed at improving oral hygiene and reducing cancer risk factors are recommended. Keywords: periodontal diseases; neoplasms; bibliometrics; databases; bibliographic 1. Introduction Periodontal disease is one of the most prevalent oral diseases, and it significantly impacts individuals and society [1] . According to the Global Oral Health Status Report 2022, severe periodontal disease affected approximately 1.08 billion people worldwide in 2019, with an age-standardized prevalence of 18.82% among individuals over 15 years old [2] . Cancer remains the foremost cause of premature death worldwide, ranking first in 57 countries and second in 70 [3] . The latest analysis of GLOBOCAN 2020 estimates indicated

FAQs

What was the database and publication window used in the bibliometric analysis?

The study used the Thomson Reuters Web of Science Core Collection database, focusing on publications from 2014 to 2023.

How many relevant articles were identified, and what trend was observed over time?

A total of 253 relevant articles were identified, showing an increasing trend in both publications and citations across the years.

Which microbiota were emphasized in highly cited research?

Highly cited articles highlighted specific oral microbiota, particularly F. nucleatum and P. gingivalis, in relation to various cancers.

Sep 21, 2026

Uploaded by Miles