GH/IGF-1 Axis as a Gerotherapeutic Target - Abstract citation ID igaf122.1103

Sep 28, 2026

Uploaded by jay

While growth hormone/insulin-like growth factor-1 (GH/IGF-1) is a well-documented modulator of aging and longevity in model organisms, its role in human aging remains less established. Epidemiologic and genetic findings from the general population and exceptional longevity cohorts indicate attenuated GH/IGF-1 signaling may mediate healthy aging and reduce risk of age-related diseases including cancer, diabetes, dementia, and cardiovascular disease. These results have supported preclinical trials of newly developed and repurposed therapeutics aimed at diminishing GH/IGF-1 signaling to potentially delay aging and associated conditions.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Background

Evidence from human cohorts

Healthy aging and disease protection

Therapeutic implications

Preclinical trials targeting GH/IGF-1

FAQs

How is GH/IGF-1 linked to aging in model organisms versus humans?

In model organisms, GH/IGF-1 is well established as a modulator of aging and longevity. In humans, its role in aging is described as less established.

What evidence suggests attenuated GH/IGF-1 signaling may promote healthy aging?

Epidemiologic and genetic evidence from the general population and exceptional longevity cohorts points to attenuated GH/IGF-1 signaling as a mediator of healthy aging.

What therapeutic strategy is being explored based on this evidence?

Preclinical trials are testing newly developed and repurposed therapeutics that diminish GH/IGF-1 signaling, with the potential to delay aging and age-related diseases.

Sep 28, 2026

Uploaded by jay