Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer

Sep 21, 2026

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Objectives: Assess how combined hematological and physical measurement indicators influence prognosis for patients undergoing surgery for gastric or colorectal cancer, and identify the most effective prognostic indicators. Methods: Select 13 hematological and 5 physical indicators, screen promising candidates using LASSO regression, then choose best predictors with time-ROC curves. Kaplan–Meier and Cox proportional risk regression evaluate survival and associations, including secondary outcomes such as length of stay, costs, ICU admission, and PGSGA scores. Results: GNRI and calf circumference (CC) show highest AUC values; GNRI-CC performs best.

LanguageEnglish

CategoryResearch & Report

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Pages10

Reading Time25 min

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Abstract

Objectives and Methods

Results and Conclusion

Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer Cancer Control Volume 31: 1–10 © The Author(s) 2024 Article reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions) [DOI: 10.1177/10732748241230888](DOI: 10.1177/10732748241230888)[ ](DOI: 10.1177/10732748241230888)[journals.sagepub.com/home/ccx](journals.sagepub.com/home/ccx) Xin Zheng 1,2,3,*, Jin-Yu Shi 1,2,3,*, Zi-Wen Wang 1,2,3,*, Guo-Tian Ruan 1,2,3, Yi-Zhong Ge 1,2,3,4, Shi-Qi Lin 1,2,3,4, Chen-An Liu 1,2,3,4, Yue Chen 1,2,3,4, Hai-Lun Xie 1,2,3, Meng-Meng Song 1,2,3, Tong Liu 1,2,3, Ming Yang 1,2,3, Xiao-Yue Liu 1,2,3, Li Deng 1,2,3,4, Ming-Hua Cong5, and Han-Ping Shi 1,2,3,4 􀀁 Abstract Objectives: To explore the effect of combined hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancer and to screen for the best prognostic indicators. Introduction: Gastric and colorectal cancer is a widespread health concern worldwide and one of the major contributors to cancer-related death. The hematological and physical measurement indicators have been shown to associate with the prognosis of patients undergoing surgery for gastric or colorectal cancer, respectively, but it is still unclear whether the combination of the two can reﬂect the prognosis more effectively. Methods: Thirteen hematological indicators and 5 physical measurement indicators were selected in this study, and the most promising ones were screened using LASSO regression. Then, the best prognostic indicators were selected by time-ROC curves. Survival curves were constructed using the Kaplan–Meier method, and the effects of hematological and physical measurement indicators on the prognosis of patients undergoing surgery for gastric or colorectal cancers were evaluated by Cox proportional risk regression analysis. In addition, the relationship between hematological and physical measurement indicators on secondary outcomes, including length of stay, hospitalization costs, intensive care unit (ICU) admission, and patients’ subjective global assessment scores (PGSGA), was explored. 1 Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China 2Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China 3Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China 4The Second Afﬁliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China 5Comprehensive Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China *Xin Zheng, Jin-Yu Shi and Zi-Wen Wang have contributed equally to this work and share ﬁrst authorship. Corresponding Authors: Li Deng, Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. Email: [dengli070@foxmail.com](dengli070@foxmail.com) Ming-Hua Cong, Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. Email: [doccong@163.com](doccong@163.com) Han-Ping Shi, Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. Email: [shihp@ccmu.edu.cn](shihp@ccmu.edu.cn) Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)) which permits non-commercial use, reproduction and distribution of the work without fur

FAQs

What is the main objective of this study?

To determine whether combining hematological indicators with physical measurements improves prognosis prediction for patients undergoing gastric or colorectal cancer surgery, and to identify the best prognostic indicators.

Which indicators were evaluated and how were the best predictors selected?

Thirteen hematological indicators and five physical measurement indicators were screened, with promising candidates selected by LASSO regression and final prognostic indicators determined using time-ROC curves.

What combination showed the best prognostic performance?

The combined nutritional prognostic index (GNRI) together with calf circumference (CC) (GNRI-CC) demonstrated the best performance for predicting prognosis in these surgical patients.

Sep 21, 2026

Uploaded by Himbo