Gastric motility and its association with adiposity and metabolic health in a cohort of Sri Lankan office workers

Sep 28, 2026

Uploaded by Stanford

Gastric motility is a core gastrointestinal function influenced by age, sex, body composition, and metabolic status, yet evidence linking these factors remains limited. A cross-sectional study assessed 130 University of Kelaniya office workers (20–50 years) using real-time ultrasonography to quantify fasting and postprandial antral areas and contraction frequency, alongside measures of adiposity and metabolic markers. Gastric motility parameters showed weak associations, mainly with lipid profiles, with patterns differing by sex, supporting targeted risk identification.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages12

Reading Time30 min

AccessFree to download

Abstract

Background

Aim

Methods

Results

Conclusion

Key Words

| W | J | G | P | World Journal of
Gastrointestinal Pathophysiology | | --- | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Pathophysiol 2025 December 22; 16(4): 112536 DOI: 10.4291/wjgp.v16.i4.112536 ISSN 2150-5330 (online) ORIGINAL ARTICLE Observational Study Gastric motility and its association with adiposity and metabolic health in a cohort of Sri Lankan office workers Pradeepa Isurumali Basnayake, Dulani Kottahachchi, Dinu Santha Chandran, Kushan Medagoda, Niranga Manjuri Devanarayana Specialty type: Gastroenterology and hepatology Provenance and peer review: Invited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s classification Scientific Quality: Grade B Novelty: Grade C Creativity or Innovation: Grade C Scientific Significance: Grade C P-Reviewer: Gunes Y, Full Professor, Türkiye Received: July 30, 2025 Revised: August 13, 2025 Accepted: October 29, 2025 Published online: December 22, 2025 Processing time: 145 Days and 15.7 Hours Pradeepa Isurumali Basnayake, Department of Physiology, Faculty of Medicine, Sabaragamuwa University of Sri Lanka, Ratnapura 70012, Sabaragamuwa Province, Sri Lanka Dulani Kottahachchi, Kushan Medagoda, Niranga Manjuri Devanarayana, Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Western Province, Sri Lanka Dinu Santha Chandran, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India Corresponding author: Niranga Manjuri Devanarayana, Professor, Department of Physiology, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 11010, Western Province, [Sri Lanka.](Sri Lanka. niranga@kln.ac.lk)[ niranga@kln.ac.lk](Sri Lanka. niranga@kln.ac.lk) Abstract BACKGROUND Gastric motility is an essential gastrointestinal function. It can be influenced by age, gender, body composition, and metabolic status. However, published data on these associations remains limited. AIM To assess the relationship between gastric motility and adiposity, and metabolic indicators in a cohort of Sri Lankan office workers. METHODS A cross-sectional study was conducted among 130 office workers (58.5% females) aged 20-50 years (mean 36.81, SD 8.85 years) of the University of Kelaniya, Sri Lanka. Gastric motility was assessed by real-time ultrasonography, using a previously validated method. Fasting antral area (FAA), postprandial antral areas at 1 minutes and 15 minutes (AA1, AA15), and antral contraction frequency (FAC) were measured, and gastric emptying rate (GER) and antral motility index were calculated. Anthropometric parameters were obtained using sensitive scales. Glycated hemoglobin, lipid profile, and liver enzyme levels were measured at an accredited laboratory. RESULTS The mean body mass index (BMI) was 24.36 (SD 4.09) kg/m2, and 39.2% were WJGP [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 22, 2025 Volume 16 Issue 4 Basnayake PI et al. Gastric motility, adiposity, and metabolic health overweight or obese. Increased abdominal adiposity was detected in 29.2% and 40.8% had high waist-to-hip ratios. Prediabetes/diabetes were observed in 20.0%, hypercholesterolemia in 47.7%, hypertriglyceridemia in 14.7%, high low-density lipoproteins in 39.2%, and elevated aspartate transaminase and alanine transaminase in 5.4% and 21.5% respectively. FAA had a weak negative correlation with high-density lipoprotein level (r = -0.227, P = 0.009), and a positive correlation with waist circumference (r = 0.235, P = 0.007), and waist-to-hip ratio (r = 0.244, P = 0.005). GER and AA1 correlated weakly with triglyceride (GER: r = 0.174, P = 0.048; AA1: r = 0.194, P = 0.027) and VLDL levels (GER: r = 0.183, P = 0.038; AA1: r = 0.195, P = 0.026). In females, AA1 positively correlated with triglycerides (r = 0.333, P = 0.003), and VLDL levels (r = 0

FAQs

What was the study aim regarding gastric motility?

To assess the relationship between gastric motility, adiposity, and metabolic indicators in a cohort of Sri Lankan office workers.

How was gastric motility measured in this study?

By real-time ultrasonography using a previously validated approach, including fasting and postprandial antral areas and antral contraction frequency, from which gastric emptying rate and antral motility index were calculated.

What overall relationship did the study find between gastric motility and metabolic health?

Gastric motility parameters had weak associations with metabolic indicators, especially lipid profiles, and to a lesser extent with adiposity indicators, with more correlations observed in females.

Sep 28, 2026

Uploaded by Stanford