From Rhythm to Resilience - The Interplay of Circadian Rhythm, Melatonin, Lifestyle, Nutrition in Psychoneuroimmunology (PNI) - Editorial

Sep 30, 2026

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Emerging evidence links circadian rhythm, melatonin signaling, nutrition, and inflammation in shaping both mental and physical health. Circadian disruptions and lifestyle imbalances contribute to neuroinflammation, mood dysregulation, and cardiometabolic dysfunction, reflected in conditions such as ADHD, major depressive disorder, metabolic syndrome, and cardiovascular diseases. This special issue emphasizes interdisciplinary research integrating circadian biology, nutrition, and psychoneuroimmunology (PNI) to support personalized and preventive psychiatry, including mechanistic studies and lifestyle-based interventions.

LanguageEnglish

CategoryHealthcare

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Pages4

Reading Time10 min

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Introduction

Interplay among circadian rhythms, nutrition, and lifestyle

Off the beat with circadian rhythm and singing the blues with a broken heart

BioMedicine | Volume 15 Issue 4 | Article 1 | | --- | --- | | 2025
From Rhythm to Resilience: The Interplay of Circadian Rhythm, Melatonin, Lifestyle, Nutrition in Psychoneuroimmunology (PNI)
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Part of the Life Sciences Commons, and the Medical Sciences Commons

This work is licensed under a Creative Commons Attribution 4.0 License. | | Recommended Citation Chang, Jane Pei-Chen and Su, Kuan-Pin (2025) "From Rhythm to Resilience: The Interplay of Circadian Rhythm, Melatonin, Lifestyle, Nutrition in Psychoneuroimmunology (PNI)," BioMedicine: Vol. 15 : Iss. 4 , Article 1. DOI: 10.37796/2211-8039 .1691 This Editorial is brought to you for free and open access by BioMedicine. It has been accepted for inclusion in BioMedicine by an authorized editor of BioMedicine. From rhythm to resilience: The interplay of circadian rhythm, melatonin, lifestyle, nutrition in psychoneuroimmunology (PNI) Chang Jane Pei-Chen a,b,c, Su Kuan-Pin a,c,d,e,* a Mind-Body Interface Research Center (MBI Lab & Care), China Medical University Hospital, Taichung, Taiwan b Child Psychiatry Division, Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan c College of Medicine, China Medical University (CMU), Taichung, Taiwan d An-Nan Hospital, China Medical University (CMU), Tainan, Taiwan e Office of Research and Development, Asia University, Taichung, Taiwan Abstract Emerging evidence reveals that circadian rhythm, melatonin signaling, nutrition, and inflammation are intricately intertwined in shaping both mental and physical health. Circadian disruptions and lifestyle imbalances contribute toneuroinflammation, mood dysregulation, and cardiometabolic dysfunction, as seen in attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), metabolic syndrome, and cardiovascular diseases. This special issue highlights interdisciplinary research that integrates circadian biology, nutrition, and psychoneuroimmunology (PNI) toward personalized and preventive psychiatry. Featured studies explore circadian and melatonin mechanisms in ADHD and MDD, the therapeutic and prophylactic potential of omega-3 polyunsaturated fatty acids (n-3 PUFAs), theneuroprotective potentical of paeoniflorin, and the role of extracellular matrix gene variants in MDD vulnerability. Additionally, evidence supporting lifestyle-based interventions such as Tai Chi underscores the value of nonpharmacological mind—body approaches. Collectively, these studies illuminate a multidimensional model linking biological rhythm, nutrition, and inflammation to mental resilience and cardiovascular well-being. Keywords: ADHD, Cardiovascular diseases, Circadian rhythm, Lifestyle, MDD, Nutrition, Psychoneuroimmunology (PNI) 1. Introduction T he interplay among circadian rhythms, nutri tion, and lifestyle provides new perspectives for addressing common mental and physical disorders. The body's internal clock orchestrates circadian rhythms, playing a crucial role in regulating immune function and neurochemical homeostasis [1]. Disruptions in these rhythms have been implicated in the development of various neuropsychiatric conditions, such as attentiondeficit hyperactivity disorder (ADHD) [2] and major depressive disorder (MDD) [3], as well as in cardiovascular diseases [4]. Furthermore, growing evidence highlights inflammation as a shared underlying mechanism among these disorders. Elevated inflammatory markers have been observed in ADHD [5], MDD [6], and cardiovascular diseases, particularly when comorbid with MDD [7]. In contrast, healthy nutritional habits and lifestyle interventions―such as regular physical activity and improved sleep hygiene―have shown promise in reducing neuroinflammation, restoring circadian balance, and promoting both mental and cardiovascular health [8]. 2. Off the beat with circa

FAQs

How are circadian rhythm and melatonin related to mental and physical disorders in this editorial?

Disruptions in circadian rhythms and melatonin secretion are described as closely linked to multiple neuropsychiatric disorders (including ADHD and MDD) as well as physical conditions such as coronary artery disease. The editorial frames inflammation as a key connecting mechanism.

What role does nutrition play according to the special issue overview?

The text highlights that nutrition and healthy lifestyle habits can help reduce neuroinflammation, restore circadian balance, and support mental and cardiovascular health. It also mentions omega-3 polyunsaturated fatty acids (n-3 PUFAs) as a featured area.

What does the special issue aim to contribute to psychiatry?

The special issue focuses on integrating circadian biology, nutrition, and psychoneuroimmunology (PNI) to advance personalized and preventive psychiatry. It includes both mechanistic research and lifestyle-based mind-body approaches such as Tai Chi.

Sep 30, 2026

Uploaded by moss~