Fibrinogen to Albumin Ratio, Lactate Dehydrogenase to Albumin Ratio and Uric Acid to Albumin Ratio in Preeclampsia

Q: How were the preeclampsia groups defined in the study?

Patients with preeclampsia were categorized into two groups based on disease severity: those without severe features and those with severe features.

Q: What differences were observed for FAR, UAR, and LAR?

FAR was significantly higher in both preeclampsia groups versus controls but showed no significant difference between the two preeclampsia severity groups. UAR and LAR differed significantly between the severe-feature and non-severe-feature groups and the control group.

Q: What did the ROC curve results show for UAR and LAR?

ROC curves for UAR produced a reported cut-off value with specific sensitivity and specificity for distinguishing severe from non-severe features. ROC curves for LAR similarly yielded a cut-off value with reported sensitivity and specificity.

Sep 30, 2026

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Preeclampsia is clinically grouped into cases with and without severe features, and this study evaluates whether fibrinogen to albumin ratio (FAR), uric acid to albumin ratio (UAR), and lactate dehydrogenase to albumin ratio (LAR) can distinguish disease severity. A retrospective cohort in Istanbul’s Basaksehir Cam and Sakura City Hospital (2020–2023) included 73 women with preeclampsia and 30 healthy pregnant controls. FAR was higher versus controls but did not differ by severity, while UAR and LAR differed across groups. ROC analyses identified UAR and LAR cut-offs with reported sensitivity and specificity. UAR and LAR are proposed as better, accessible biomarkers for severe-feature-related delivery risk.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages10

Reading Time25 min

AccessFree to download

Abstract

1. Introduction

Article Fibrinogen to Albumin Ratio, Lactate Dehydrogenase to Albumin Ratio and Uric Acid to Albumin Ratio in Preeclampsia Esra Selvi 1, *, Kübra Kurt Bilirer 1, Aybekcan Batman 1, ˙Izel Günay 2, Verda Alpay 1 and Hakan Erenel 1 Academic Editor: Everett F. Magann Received: 18 November 2025 Revised: 16 December 2025 Accepted: 17 December 2025 Published: 19 December 2025 Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. 1 Department of Perinatology, Ba¸sak¸sehir Çam and Sakura City Hospital, 34480 Istanbul, Turkey; [kubrakbilirer@gmail.com](kubrakbilirer@gmail.com) (K.K.B.); [batman.aybek.can@gmail.com](batman.aybek.can@gmail.com) (A.B.); [verda_alpay@yahoo.com](verda_alpay@yahoo.com) (V.A.); [hakanerenel@yahoo.com](hakanerenel@yahoo.com) (H.E.) 2 Department of Obstetrics and Gynecology, Ba¸sak¸sehir Çam and Sakura City Hospital, 34480 Istanbul, Turkey; [zel.gunay@gmail.com](zel.gunay@gmail.com) * Correspondence: [esraorak@yahoo.com.tr](esraorak@yahoo.com.tr); Tel.: +90-537-491-6104 Abstract Background/Objectives: Preeclampsia can be divided into two groups (with and without severe features) based symptom severity. We aimed to distinguish these two entities with the aid of fibrinogen to albumin ratio (FAR), uric to acid albumin ratio (UAR) and LDH to albumin ratio (LAR) . Methods: This retrospective study was conducted in Istanbul Basaksehir Cam and Sakura City Hospital between 2020 and 2023 . Seventy-three patients with preeclampsia were included in this study which were categorized into two groups according to disease severity: 40 patients with preeclampsia without severe features and 33 patients with severe features. Additionally, 30 healthy pregnant women were included as a control group. Neutrophil–lymphocyte ratio (NLR), monocyte–lymphocyte ratio (MLR), platelet–lymphocyte ratio (PLR), mean platelet volume (MPV), red cell distribution width (RDW), mean platelet volume (MPV), Uric acid, LDH, AST, ALT, fibrinogen, albumin, FAR, UAR and LAR were compared among the groups. Results: FAR was significantly higher in preeclampsia patients with and without severe features compared to control group (Odds ratio 8.32 for ≥0.139 vs. <0.139, p < 0.001) . There was no significant difference in FAR levels between preeclampsia patients according to disease severity. UAR and LAR were significantly different between preeclampsia patients with and without severe features and the control group (p < 0.001) . Receiver operating characteristics (ROC) curves for UAR showed that a cut-off value of 1.727 had a sensitivity of 73% and a specificity of 68% in discriminating between preeclampsia with and without severe features (Odds ratio 5.53 for ≥1.727 vs. <1.727) . ROC curves for LAR showed that a cut-off value of 79.09 had a sensitivity of 85% and a specificity of 73% in discriminating between preeclampsia with and without severe features (Odds ratio 14.76 for ≥79.09 vs. <79.09) . Conclusions: UAR and LAR appear tobe better markers than FAR for identifying preeclamptic patients who require delivery due to severe features. They are easily accessible and promising biomarkers, and to our knowledge, this is the first study to evaluate LAR in this context. Further studies are needed to validate their diagnostic accuracy and compare their performance with established biomarkers. Keywords: albumin; fibrinogen; LDH; preeclampsia; uric acid 1. Introduction Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality, occurring in 5–10% of pregnancies and characterized by newly developed hy- pertension and proteinuria after 20 weeks of gestation [1,2] . Although endothelial cell activation, intravascular inflammation, and syncytiotrophoblast stress play crucial roles in the underlying pathophysiology, the exact pathological mechanism of preec

FAQs

How were the preeclampsia groups defined in the study?

Patients with preeclampsia were categorized into two groups based on disease severity: those without severe features and those with severe features.

What differences were observed for FAR, UAR, and LAR?

FAR was significantly higher in both preeclampsia groups versus controls but showed no significant difference between the two preeclampsia severity groups. UAR and LAR differed significantly between the severe-feature and non-severe-feature groups and the control group.

What did the ROC curve results show for UAR and LAR?

ROC curves for UAR produced a reported cut-off value with specific sensitivity and specificity for distinguishing severe from non-severe features. ROC curves for LAR similarly yielded a cut-off value with reported sensitivity and specificity.

Sep 30, 2026

Uploaded by Aldword