FAM13A polymorphisms are associated with a specific susceptibility to clinical progression of oral cancer in alcohol drinkers

Sep 24, 2026

Uploaded by Jacob

Study addresses how FAM13A single nucleotide polymorphisms (SNPs) relate to oral cancer risk and progression, focusing especially on alcohol drinking. Methods examine rs1059122, rs3017895, rs3756050, and rs7657817 in FAM13A using TaqMan allelic discrimination. General analyses show no significant differences between controls and patients for clinical stage, tumor size, lymph node invasion, distant metastasis, or pathology. In alcohol drinkers, rs3017895 G genotype increases well-differentiated status.

LanguageEnglish

CategoryHealthcare

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Reading Time23 min

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Abstract

Background

Methods

Results

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Introduction

Materials and methods

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Hsieh et al. BMC Cancer (2023) 23:607 [https://doi.org/10.1186/s12885-023-11052-5](https://doi.org/10.1186/s12885-023-11052-5) BMC Cancer RESEARCH Open Access FAM13A polymorphisms are associated with a specific susceptibility to clinical progression of oral cancer in alcohol drinkers Ming‑Ju Hsieh 1,2,3, Yu‑Sheng Lo1, Yun‑Jung Tsai4,5, Hsin‑Yu Ho 1, Chia‑Chieh Lin 1, Yi‑Ching Chuang1, Shu‑Hui Lin4,5,6 and Mu‑Kuan Chen7,8* Abstract Background Single nucleotide polymorphism (SNP) is a genetic variation that occurs when a single nucleotide base in the DNA sequence varies between individuals and is present in at least 1% of the population. Genetic variants in FAM13A are associated with different types of chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and lung cancer. However, there is little literature on the association of FAM13A genotypes with oral cancer. Therefore, this project will explore the correlation between the FAM13A genotype and the formation of oral cancer. Methods In this project, we will examine the presence of gene polymorphisms gene polymorphisms of rs1059122, rs3017895, rs3756050, and rs7657817 in the FAM13A gene exon, and combine the expression of these genes to try to clarify the impact of the FAM13A gene polymorphism on oral cancer. First, four loci (rs1059122, rs3017895, rs3756050, and rs7657817) of the FAM13A SNP were genotyped using TaqMan allelic discrimination. Results By estimating OR and AOR, FAM13A exhibited different genotypic variables in four SNPs that were not statistically significant between controls and patients with oral cancer. The results of the general analysis showed that different distributions of allelic types did not affect clinical stage, tumour size, lymph node invasion, distant metas‑ tasis, and pathological differentiation status. However, in the alcohol drinking group specifically, patients with the rs3017895 SNP G genotype had a 3.17‑fold (95% CI, 1.102–9. 116; p = 0. 032) increase in the well differentiated state of cells compared to patients with the A allele. Conclusions Our results suggested that the SNP rs3017895 FAM13A could contribute to oral cancer. More sample studies are needed in the future to confirm our results and more functional studies are needed to investigate their relevant roles in the development of oral cancer. Keywords Polymorphism, Oral, FAM13A, Alcohol drinkers *Correspondence: Mu‑Kuan Chen [53780@cch.org.tw](53780@cch.org.tw) Full list of author information is available at the end of the article © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[. The Creative Commons Public Domain Dedication waiver (](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[http://creativeco](http://creativeco)[mmons.org/publicdomain/zero/1.0/](mmons.org/publicdomain/zero/1.0/)) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Hsieh et al. BMC Cancer (2023) 23:607 Introduction

FAQs

Which FAM13A SNPs were evaluated in the study?

The study examined rs1059122, rs3017895, rs3756050, and rs7657817 in the FAM13A gene exon.

Did FAM13A polymorphisms show significant associations in the overall comparison?

Overall analyses found genotypic variables in four SNPs were not statistically significant between controls and oral cancer patients for the assessed clinical and pathological outcomes.

What was the key finding among alcohol drinkers?

In the alcohol drinking group, rs3017895 G genotype was associated with a 3.17-fold increase in the well-differentiated state compared with the A allele.

Sep 24, 2026

Uploaded by Jacob