Exploring the role ofthe inflammasomes on prostate cancer: Interplay with obesity - Abstract

Sep 24, 2026

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Obesity is a weight-related disorder marked by excessive adipose tissue growth and dysfunction, driving a systemic chronic low-grade inflammatory state. Inflammation is also a classic cancer hallmark influencing carcinogenesis and tumor progression. Inflammasomes, novel molecular complexes that respond to diverse insults, affect multiple metabolic disorders, yet their role in cancer biology remains unclear. Prostate cancer shows a strong inflammatory component, particularly in elderly patients with obesity. This review explains inflammasome components in PCa, links them to obesity, and summarizes clinical trials on inflammasome targeting.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages23

Reading Time58 min

AccessFree to download

Abstract

Keywords & Abbreviations

Background

Inflammation and prostate cancer risk

Chronic inflammation and recurrence

Genetic polymorphisms and inflammatory genes

Exploring the role ofthe inflammasomes on prostate cancer: Interplay with obesity Jesús M. Pérez‑Gómez1,2,3,4 · Antonio J. Montero‑Hidalgo1,2,3,4 · Antonio C. Fuentes‑Fayos1,2,3,4 · André Sarmento‑Cabral1,2,3,4 · Rocio Guzmán‑Ruiz1,2,3,4 · María M. Malagón1,2,3,4 · Aura D. Herrera‑Martínez1,3,5 · Manuel D. Gahete1,2,3,4 · Raúl M. Luque1,2,3,4 Accepted: 21 September 2023 / Published online: 11 October 2023 © The Author(s) 2023 Abstract Obesity is a weight-related disorder characterized by excessive adipose tissue growth and dysfunction which leads to the onset of a systemic chronic low-grade inflammatory state. Likewise, inflammation is considered a classic cancer hallmark affecting several steps of carcinogenesis and tumor progression. In this regard, novel molecular complexes termed inflammasomes have been identified which are able to react to a wide spectrum of insults, impacting several metabolic-related disorders, but their contribution to cancer biology remains unclear. In this context, prostate cancer (PCa) has a markedly inflammatory component, and patients frequently are elderly individuals who exhibit weight-related disorders, being obesity the most prevalent condition. Therefore, inflammation, and specifically, inflammasome complexes, could be crucial players in the interplay between PCa and metabolic disorders. In this review, we will: 1) discuss the potential role of each inflammasome component (sensor, molecular adaptor, and targets) in PCa pathophysiology, placing special emphasis on IL-1β/ NF-kB pathway and ROS and hypoxia influence; 2) explore the association between inflammasomes and obesity, and how these molecular complexes could act as the cornerstone between the obesity and PCa; and, 3) compile current clinical trials regarding inflammasome targeting, providing some insights about their potential use in the clinical practice. Keywords Obesity · Prostate cancer · Inflammasome · Adipose tissue · IL-1β · NF-κB Abbreviations AT Adipose Tissue ATMs Adipose Tissue Macrophages AR Androgen Receptor * Raúl M. Luque [raul.luque@uco.es](raul.luque@uco.es); [bc2luhur@uco.es](bc2luhur@uco.es) Jesús M. Pérez-Gómez [b42pegoj@uco.es](b42pegoj@uco.es) Antonio J. Montero-Hidalgo [b42mohia@uco.es](b42mohia@uco.es) Antonio C. Fuentes-Fayos [b22fufaa@uco.es](b22fufaa@uco.es) André Sarmento-Cabral [andre.cabral@imibic.org](andre.cabral@imibic.org) Rocio Guzmán-Ruiz [bc2gurur@uco.es](bc2gurur@uco.es) [Mar](Mar)í[a](a) M. Malagón [bc1mapom@uco.es](bc1mapom@uco.es) Aura D. Herrera-Martínez [aurita.dhm@gmail.com](aurita.dhm@gmail.com) BPH Benign Prostate Hyperplasia BMI Body Mass Index CARD Caspase Activation and Recruitment Domain CRPC Castration Resistant Prostate Cancer Manuel D. Gahete [bc2gaorm@uco.es](bc2gaorm@uco.es) 1 Maimonides Biomedical Research Institute of Cordoba (IMIBIC), IMIBIC Building, Av. Menéndez Pidal s/n, 14004 Córdoba, Spain 2 Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Cordoba, Spain 3 Hospital Universitario Reina Sofía (HURS), Cordoba, Spain 4 Centro de Investigación Biomédica en Red de Fisiopatologíade la Obesidad y Nutrición,(CIBERobn), Cordoba, Spain 5 Endocrinology and Nutrition Service, HURS/IMIBIC, Córdoba, Spain CLRs C-type lectin receptors DAMPs Damage-Associated Molecular Patterns EMT Epithelial to Mesenchymal Transition HIF-1α Hypoxia-inducible factor 1-alpha IL-18 Interleukin-18 IL18BP Interleukin-18 Binding Protein IL-1β Interleukin-1β NLRs Nucleotide-binding Oligomerization Domainlike receptors PYD PAAD/DAPIN Domain PAMPs Pathogen-Associated Molecular Patterns PRRs Pattern Recognition Receptors PPAT Periprostatic Adipose Tissue PIA Proliferative Inflammatory Atrophy PCa Prostate Cancer PIN Prostatic Intraepithelial Neoplasia ROS Reactive Oxygen Species RLRs Retinoic acid-Inducible Gene 1 SNPs Single Nucleotide Polymorphisms SVF Stromal-Vascular Fraction TLRs Tol

FAQs

Why is obesity linked to chronic inflammation relevant to prostate cancer?

Obesity causes excessive adipose tissue growth and dysfunction that sustains a systemic chronic low-grade inflammatory state. Since inflammation influences carcinogenesis and tumor progression, this provides a mechanistic basis for considering obesity in prostate cancer biology.

What role do inflammasomes play in prostate cancer according to the review scope?

The review focuses on potential contributions of inflammasome components—sensors, molecular adaptors, and targets—to prostate cancer pathophysiology. It emphasizes the IL-1β/NF-κB pathway and the influence of ROS and hypoxia.

How does the review connect inflammasomes and obesity?

It explores the association between inflammasomes and obesity, proposing these molecular complexes as potential molecular connectors between obesity-related metabolic disorders and prostate cancer.

Sep 24, 2026

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