Evaluation of variations in urine laminin-γ2 monomer in non-muscle-invasive bladder cancer before and after transurethral resection of the bladder tumor

Sep 23, 2026

Urine laminin-γ2 monomer (Lm-γ2m) was previously reported as a diagnostic biomarker for non-muscle-invasive bladder cancer (NMIBC), but its prognostic value after transurethral resection of bladder tumor (TURBT) remained unclear. This study measured urine Lm-γ2m prospectively in 41 NMIBC patients before TURBT and 3 months after, and assessed relationships with recurrence within 1 year and compared with traditional urine markers.

LanguageEnglish

CategoryResearch & Report

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Pages8

Reading Time20 min

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Abstract

Background

Methods

Results

Conclusions

Introduction

Table 1 Characteristics of evaluated patients with NMIBC

Osaka et al. BMC Cancer (2026) 26:319 BMC Cancer [https://doi.org/10.1186/s12885-026-15658-3](https://doi.org/10.1186/s12885-026-15658-3) RESEARCH Open Access Evaluation of variations in urine laminin-γ2 monomer in non-muscle-invasive bladder cancer before and after transurethral resection of the bladder tumor Kimito Osaka1,8, Takeshi Kishida 1, Susumu Umemoto 1,9, Takashi Karashima2*, Masatoshi Nakagawa3, Eisaku Yoshida3, Toru Yoshimura3, Masahiko Sakaguchi4,5,10,11, Keiji Inoue2, Naohiko Koshikawa5,6,7, Motoharu Seiki7 and Taro Shuin2 Abstract Background We have previously reported urine laminin-γ2 monomer (Lm-γ2m) as a diagnostic biomarker for patients with non-muscle-invasive bladder cancer (NMIBC) . However, Lm-γ2m has not been evaluated as a prognostic biomarker for patients with NMIBC after transurethral resection of bladder tumor (TURBT) . This study aimed to clarify whether urine Lm-γ2m offers a useful prognostic biomarker for patients with NMIBC after TURBT. Methods Participants comprised 41 patients with NMIBC. Urine Lm-γ2m was prospectively measured before and 3 months after TURBT and values were compared. Traditional urine tumor markers such as urine nuclear matrix protein 22 and cytology were also evaluated before and after TURBT. Patients were stratified by the presence of recurrence within 1 year after TURBT and values of urine Lm-γ2m before and after TURBT were analyzed. Results Mean urine Lm-γ2m values were significantly decreased after TURBT compared to before surgery. Mean urine Lm-γ2m before and after TURBT were higher in patients with recurrence within 1 year after surgery than inpatients without recurrence. Urine Lm-γ2m before TURBT was also important to predict prognosis in patients with NMIBC treated using TURBT. Conclusions These results suggest urine Lm-γ2m as a potentially useful biomarker for NMIBC before and after TURBT. Keywords Bladder cancer, non, Muscle, Invasive bladder cancer, laminin, γ2, urine laminin, γ2 monomer, biomarker *Correspondence: Takashi Karashima [karasima@kochi-u.ac.jp](karasima@kochi-u.ac.jp) 1Department of Urology, Kanagawa Cancer Center, Yokohama, Japan 2Department of Urology, Kochi Medical School, Nankoku, Japan 3Diagnostic Division, Abbott Japan LLC, Chiba, Japan 4Integrated Center for Advanced Medical Technologies, Kochi Medical School, Nankoku, Japan 5Kanagawa Cancer Center Research Institute, Yokohama, Japan 6School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan 7Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan 8Department of Urology, Yokohama City University Medical Center, Yokohama, Japan 9Yokohama Futamatagawa Umemoto Urology Clinic, Yokohama, Japan 10Department of Engineering Informatics, Faculty of Information and Communication Engineering, Osaka Electro-Communication University, Neyagawa, Japan 11Unit of Cancer Education, Kanagawa Cancer Center Research Institute, Yokohama, Japan © The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence,

FAQs

What question does the study address about urine Lm-γ2m?

It clarifies whether urine laminin-γ2 monomer (Lm-γ2m) can serve as a useful prognostic biomarker for NMIBC patients after TURBT.

How was urine Lm-γ2m measured in the study?

Urine Lm-γ2m was measured prospectively before TURBT and again 3 months after TURBT, and values were compared.

What were the key findings related to recurrence prognosis?

Urine Lm-γ2m decreased after TURBT, and levels before and after TURBT were higher in patients who had recurrence within 1 year compared with those without recurrence.

Sep 23, 2026

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