Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing - A Multicenter Retrospective Cohort Study

Q: What was the primary objective of this multicenter study?

To evaluate the role of plasma cytokine detection in screening for endometrial cancer and assessing tumor progression in patients with abnormal uterine bleeding.

Q: Which cytokines were identified as independent risk factors for endometrial cancer?

Low IL-4 and high IL-8 were independent risk factors for endometrial cancer in patients with abnormal uterine bleeding.

Q: How did the diagnostic models improve prediction accuracy for cancer risk and deep myometrial invasion?

Combining IL-4, IL-8, CA125, and menopausal status improved endometrial cancer risk accuracy (AUC 0.816). For deep myometrial invasion, combining IL-6, IL-8, and Monocyte counts improved assessment accuracy (AUC 0.753).

Sep 21, 2026

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Objective: Evaluate plasma cytokine detection for endometrial cancer screening and for assessing tumor progression in women with abnormal uterine bleeding. Methods: A multicenter retrospective cohort of 287 patients underwent cytokine measurement, routine blood tests, and tumor marker assessment; links between indicators and carcinogenesis/progression were tested, and independent risk factors were modeled using multivariate binary logistic regression with a diagnostic prediction model. Results: Low IL-4 and high IL-8 predicted endometrial cancer, and adding IL-4, IL-8, CA125, and menopausal status improved accuracy (AUC 0.816); high IL-6 and IL-8 predicted deep myometrial invasion (AUC 0.753). Conclusions: IL-4, IL-8, and IL-6 support monitoring endometrial cancer incidence and progression.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages11

Reading Time28 min

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Abstract

Objective

Methods

Results

Conclusions

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Ivyspring International Publisher InternationalJournal of Medical Sciences 2024; 21(4): 601-611. doi: 10.7150/ijms.91506 Research Paper Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study Jincheng Ma1,2,3*, Dabin Liu4*, Xiaodan Mao1,2,3, Leyi Huang1,2,3, Yuan Ren1,2,3, Xiaozhen Xu5, Xiaoli Huang6,7, Caiping Deng8, Feifeng Shi5􀀍, Pengming Sun1,2,3,4􀀍 1. Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, Fujian, China. 2. Fujian Key Laboratory of Women and Children’s Critical Diseases Research, Fujian Maternity and Child Health Hospital, Fuzhou 350001, Fujian, China. 3. Fujian Clinical Research Center for Gynecological Oncology, Fujian Maternity and Child Health Hospital, Fuzhou 350001, Fujian, China. 4. Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, Fujian, China. 5. Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian, China. 6. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China. 7. Department of Obstetrics and Gynecology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian, China. 8. The Second Hospital of Nanping City, Nanping 354200, Fujian, China. * These authors contributed equally to this work. 􀀍 Corresponding authors: Feifeng Shi ([ffshi63@sina.com](ffshi63@sina.com)) and Pengming Sun ([fmsun1975@fjmu.edu.cn](fmsun1975@fjmu.edu.cn)) . © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions. Received: 2023.10.25; Accepted: 2024.01.09; Published: 2024.01.21 Abstract Objective: This study aimed to evaluate the role of plasma cytokine detection in endometrial cancer screening and tumor progression assessment in patients with abnormal uterine bleeding. Methods: In this multicenter retrospective cohort study of 287 patients with abnormal uterine bleeding, comprehensive clinical information and laboratory assessments, including cytokines, routine blood tests, and tumor markers, were performed. Associations between the clinical indicators and endometrial carcinogenesis/progression were evaluated. The independent risk factors for endometrial cancer and endometrial cancer with deep myometrial invasion were analyzed using multivariate binary logistic regression. Additionally, a diagnostic model was used to evaluate the predictive efficacy of these identified risk factors. Results: In patients with abnormal uterine bleeding, low IL-4 and high IL-8 levels were independent risk factors for endometrial cancer (p < 0.05). Combining IL-4, IL-8, CA125, and menopausal status improved the accuracy of assessing endometrial cancer risk. The area under curve of the model is 0.816. High IL-6 and IL-8 levels were independent risk factors for deep myometrial invasion in patients with endometrial cancer (p < 0.05) . Similarly, combining IL-6, IL-8, and Monocyte counts enhanced the accuracy of assessing endometrial cancer risk with deep myometrial invasion. The area under curve of the model is 0.753. Conclusions: Cytokines such as IL-4, IL-8, and IL-6 can serve as markers for monitoring endometrial cancer and its progression in women with abnormal uterine bleeding. Keywords: endometrial cancer, cytokine, abnormal uterine bleeding, biomarker, inflamm

FAQs

What was the primary objective of this multicenter study?

To evaluate the role of plasma cytokine detection in screening for endometrial cancer and assessing tumor progression in patients with abnormal uterine bleeding.

Which cytokines were identified as independent risk factors for endometrial cancer?

Low IL-4 and high IL-8 were independent risk factors for endometrial cancer in patients with abnormal uterine bleeding.

How did the diagnostic models improve prediction accuracy for cancer risk and deep myometrial invasion?

Combining IL-4, IL-8, CA125, and menopausal status improved endometrial cancer risk accuracy (AUC 0.816). For deep myometrial invasion, combining IL-6, IL-8, and Monocyte counts improved assessment accuracy (AUC 0.753).

Sep 21, 2026

Upload by Finn