Elucidating the Role of Steroid Hormone Receptors in Anaplastic Thyroid Carcinoma and Pancreatic Ductal Carcinoma Models - Issue Supplement 1 - Presentation

Sep 21, 2026

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Steroid hormones regulate transcriptional mechanisms across many cancers through context-dependent control by ligands, cofactors, and dynamic posttranslational modifications. Despite links between elevated steroid hormones or steroid hormone receptors and multiple cancers, the potential of SR-modulated transcription to limit tumor growth remains insufficiently studied. This work focuses on pancreatic ductal adenocarcinoma (PDAC) and anaplastic thyroid carcinoma (ATC), both aggressive and increasingly prevalent, associated with metabolic and endocrine alterations. Using public datasets and panels of PDAC and ATC models, the study examines expression of mixed steroid receptors and tests whether related receptors (PR, GR, MR), together with posttranslational modifications, ligand binding, and selected cofactors, shape SR actions under activated signaling pathways.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Abstract citation ID bvae163.1804

Steroid hormones and context-dependent transcription in cancer

Focus cancers: PDAC and ATC

Expression of mixed steroid receptors and study hypothesis

Mechanisms: posttranslational modifications, ligand binding, cofactors

Presentation details

Abstract citation ID: bvae163.1804 Steroid Hormones_Nuclear Receptors_and Coregulators 7340 Elucidating the Role of Steroid Hormone Receptors in Anaplastic Thyroid Carcinoma and Pancreatic Ductal Carcinoma Models O. M. Stockert and C. A. Lange University of Minnesota, Minneapolis, MN Disclosure: O.M. Stockert: None. C.A. Lange: None. Steroid hormones play important roles in modulating transcription mechanisms in a variety of cancers, including breast cancer, prostate cancer, and ovarian cancer. These interactions are highly context-dependent and regulated by diverse ligands, cofactors, and dynamic posttranslational modiﬁcations that occur in response to the activation of stress-sensing and oncogenic signaling pathways. Numerous other cancers are associated with elevated steroid hormones, steroid hormone receptors, or both, but have not been studied to explore the possibility of leveraging steroid or steroid receptor (SR)-modulated transcriptional regulation to combat cancerous growth. Two of these cancers are pancreatic ductal adenocarcinoma (PDAC) and anaplastic thyroid carcinoma (ATC) . PDAC isan aggressive cancer with a very poor 5-year survival of 8-11% . It is also rapidly growing in incidence and has been shown to be associated with other increasing health conditions, including diabetes and obesity. PDAC is associated with metabolic reprogramming and elevated Progesterone Receptor (PR), Glucocorticoid Receptor (GR), and Mineralocorticoid Receptor (MR) expression. ATC is another aggressive cancer with less than 10% 6-month survival from diagnosis. Like PDAC, ATC has a rapidly increasing incidence and is associated with obesity and high-fat diets. ATC is also associated with elevated cholesterol biosynthesis and elevated GR expression. Herein, we probed public data sets and screened a panel of PDAC and ATC models to demonstrate the expression of mixed SRs. In this study, we take an initial exploration of the hypothesis that related SRs (such as PR, GR, and/ or MR) contribute to PDAC and ATC progression and that post-translational modiﬁcations, ligand binding, and/or selected cofactors modulate SR actions in the context of activated signaling pathways associated with these aggressive cancers. This study gives us a preliminary understanding of the potential role of steroid hormones and their receptors in the aggressive biology of two deadly and increasingly prevalent endocrine cancers in aging and obese populations. Presentation: 6/3/2024 J Endocrine Soc, Volume 8, Issue Supplement_ 1, October–November 2024 A948

FAQs

Which cancer models are analyzed in this study?

The study examines pancreatic ductal adenocarcinoma (PDAC) and anaplastic thyroid carcinoma (ATC) using public datasets and screened model panels.

What is the main hypothesis about steroid hormone receptors?

The hypothesis is that related steroid receptors (such as PR, GR, and MR) contribute to PDAC and ATC progression, with their actions modulated by posttranslational modifications, ligand binding, and selected cofactors.

What mechanisms are proposed to regulate steroid receptor actions?

Steroid receptor activity is described as shaped by posttranslational modifications, ligand binding, and cofactors in the context of activated signaling pathways associated with these cancers.

Sep 21, 2026

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