Efficacy and safety of lidocaine versus sufentanil in patient-controlled intravenous analgesia after laparoscopic colorectal cancer surgery: a prospective, randomized, doubleblind clinical trial

Q: What was the study’s primary endpoint for comparing lidocaine and sufentanil PCIA?

The primary endpoint was the visual analogue scale (VAS) pain score during movement at 24 hours after surgery.

Q: How did the two groups compare in postoperative pain scores over time?

VAS pain scores at rest and during movement were not significantly different between the lidocaine and sufentanil groups at 6, 12, 24, 36, and 48 hours.

Q: What outcomes favored lidocaine-based PCIA?

Patient satisfaction was significantly higher with lidocaine, and the incidence of postoperative nausea and vomiting (PONV) was significantly lower than with sufentanil.

Sep 29, 2026

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Lidocaine-based patient-controlled intravenous analgesia (PCIA) is compared with sufentanil-based PCIA for postoperative pain management in patients undergoing laparoscopic colorectal cancer surgery. A total of 126 patients received randomized assignment in a 1:1 ratio, with primary assessment using visual analogue scale (VAS) pain during movement at 24 h and secondary measures spanning multiple time points, bowel function, hospitalization metrics, satisfaction, and adverse events. Pain scores at rest and movement were similar between groups, while satisfaction and PONV favored lidocaine. Lidocaine PCIA was concluded to relieve postoperative pain, reduce PONV incidence, and improve satisfaction.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages9

Reading Time23 min

AccessFree to download

Abstract

Background

Methods

Results

Conclusions

Trials registration

Introduction

Postoperative pain burden in colorectal surgery

Current analgesic modalities and limitations

Rationale for PCIA and comparison of anesthetics

Wu et al. BMC Anesthesiology (2026) 26:12 [https://doi.org/10.1186/s12871-025-03506-z](https://doi.org/10.1186/s12871-025-03506-z) BMC Anesthesiology RESEARCH Open Access Efficacy and safety of lidocaine versus sufentanil in patient-controlled intravenous analgesia after laparoscopic colorectal cancer surgery: a prospective, randomized, doubleblind clinical trial Yumin Wu 1†, Bin Tian2†, Lewen Li3, Ruijuan Liu2, Zhenying Zhang2, Wenjie Zhang4, Song Qu5 and Wenjun Yan2* Abstract Background This study aimed to compare the efficacy and safety of lidocaine-based patient-controlled intravenous analgesia (PCIA) with sufentanil-based PCIA for managing postoperative pain in patients undergoing laparoscopiccolorectal cancer surgery. Methods A total of 126 patients were randomly assigned in a 1:1 ratio to lidocaine group (group L, n = 63) or the sufentanil group (group S, n = 63) . The primary endpoint was visual analogue scale (VAS) pain score during movement at 24 h after surgery. Secondary endpoints included VAS pain scores at rest and during movement at 6, 12, 36, and 48 h after surgery, the time of first flatus and defecation after the surgery, postoperative hospitalization time and total hospitalization costs, patient satisfaction scores, and the incidence of adverse events. Results There was no significant difference between the two groups in VAS pain scores at rest and during movement at 6, 12, 24, 36, and 48 h after surgery (all p > 0. 05) . The time to first flatus and defecation, as well as postoperative hospitalization time and total hospitalization expenses, were also similar between the two groups (all p > 0. 05) . However, satisfaction score was significantly higher in group L compared to group S (p < 0. 05), and the incidence of postoperative nausea and vomiting (PONV) was significantly lower in group L than in group S (p < 0. 05) . Conclusions Lidocaine-based PCIA can effectively relieve postoperative pain, decrease the incidence of PONV, and improve patient satisfaction in patients undergoing laparoscopic colorectal cancer surgery. Trials registration The study was registered on the Chinese Clinical Trial Registry (ChiCTR) with the registration number ChiCTR2300068854, with the registration date being March 1, 2023. Keywords Lidocaine, Colorectal neoplasms, Patient-Controlled analgesia, Postoperative period †Yumin Wu and Bin Tian contributed equally to this work and are co-first author. *Correspondence: Wenjun Yan [13893370700@163.com](13893370700@163.com) Full list of author information is available at the end of the article © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/. Wu et al. BMC Anesthesiology (2026) 26:12 Introduction Radical tumor resection is the primary treatment for improving the prognosis and survival rate of patients with colorectal cancer [1]. However, approximately 70.8% of patients experience moderate-to-severe pain within 5 h after surgery, and the in

FAQs

What was the study’s primary endpoint for comparing lidocaine and sufentanil PCIA?

The primary endpoint was the visual analogue scale (VAS) pain score during movement at 24 hours after surgery.

How did the two groups compare in postoperative pain scores over time?

VAS pain scores at rest and during movement were not significantly different between the lidocaine and sufentanil groups at 6, 12, 24, 36, and 48 hours.

What outcomes favored lidocaine-based PCIA?

Patient satisfaction was significantly higher with lidocaine, and the incidence of postoperative nausea and vomiting (PONV) was significantly lower than with sufentanil.

Sep 29, 2026

Upload by Rainbow Cat