Effects of Dietary Supplementation with Coriander Seed Powder on Serum Lipid Profile, Glycemic Indices, and Oxidative Stress Biomarkers in Patients with Type 2 Diabetes Mellitus - A Randomized, Double-Blind, Placebo-Controlled Trial

Q: What was the main aim of the study?

To assess how coriander seed powder supplementation affects serum lipid profiles, glycemic indices, and oxidative stress biomarkers in patients with type 2 diabetes mellitus.

Q: How was the study designed and what doses were used?

A randomized, double-blind, placebo-controlled trial with 40 participants. The intervention group received coriander seed powder 1,000 mg/day and the placebo group received placebo 1,000 mg/day for 6 weeks.

Q: Which outcomes improved after coriander seed supplementation?

FBS, serum insulin, HOMA-IR, total cholesterol, triglycerides, LDL-C, and MDA decreased, while total antioxidant capacity increased significantly after treatment.

Sep 29, 2026

Uploaded by ahduag

This randomized, double-blind, placebo-controlled trial evaluated coriander seed powder supplementation on serum lipid profiles, glycemic indices, and oxidative stress biomarkers in 40 patients with type 2 diabetes mellitus aged 30–60 years. Participants received 1,000 mg/day coriander seed powder (n=20) or placebo (n=20) for 6 weeks. The powder significantly reduced fasting blood serum glucose, insulin, HOMA-IR, total cholesterol, triglycerides, LDL-C, and malondialdehyde, while total antioxidant capacity increased (P<0.05). Anthropometric measures did not differ between groups.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages10

Reading Time25 min

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Abstract

Introduction

Diabetes mellitus and oxidative stress

Rationale for herbal supplementation

Prev. Nutr. Food Sci. 2025;30(6):529-538 [https://doi.org/10.3746/pnf.2025.30.6.529](https://doi.org/10.3746/pnf.2025.30.6.529)[ ](https://doi.org/10.3746/pnf.2025.30.6.529)[ISSN 2287-8602](ISSN 2287-8602) Effects of Dietary Supplementation with Coriander Seed Powder on Serum Lipid Profile, Glycemic Indices, and Oxidative Stress Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial Sanaz Zamany 1, Ali Barzegar2, Baharak Aghapour3, and Faranak Ferdosi4 1Students’Research Committee, Faculty of Nutrition and Food Sciences, 2Community Nutrition Department, Faculty of Nutrition and Food Sciences, and 4 Department of Food and Drug Control, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran 3Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran ABSTRACT: This study aimed to investigate the effects of coriander seed supplementation on serum lipid profiles, glycemic indices, and oxidative stress biomarkers in patients with type 2 diabetes mellitus (T2DM). In total, 40 such patients aged 30－60 years were allocated into two groups receiving either coriander seed powder (1,000 mg/d, n=20) or placebo (1,000 mg/d, n=20) for 6 weeks. Serum lipid profile: total cholesterol (TC), high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol (LDL-C), and triglycerides (TGs); anthropometric measurements; dietary intake; and biochemical parameters including fasting blood serum (FBS), serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and malondialdehyde (MDA); and total antioxidant capacity (TAC) were assessed before and after supplementation. Coriander seed powder markedly reduced the FBS (156.15±23.19 to 130.30±21.15 mg/dL), serum insulin (17.72±0.47 to 17.12±0.76 􀁐U/mL), HOMA-IR (6.82±0.95 to 5.52±0.99), TC (183.85±55.68 to 145.20±31.36 mg/dL), TG (152.50±37.59 to 130.40±27.96 mg/dL), LDL-C (127.35±23.45 to 111.40±25.71 mg/dL), and MDA (1.65±0.15 to 1.49±0.15 nmol/mL). However, the serum TAC significantly increased (1.93±0.12 to 1.97±0.09 mmol/L) (P <0.05). Anthropometric measurements did not differ remarkably between groups. Post-dose significant inter-group differences in FBS, serum insulin, HOMA-IR, TC, TG, LDL-C, MDA, and TAC levels were identified after adjusting for baseline values (P <0.05). This study demonstrated that coriander seed supplementation positively improved glycemic indices, lipid profile, and oxidative stress status in patients with T2DM, suggesting its potential as a useful complementary treatment for managing this condition. Keywords: diabetes mellitus type 2, glycemic index, oxidative stress, seeds INTRODUCTION Diabetes mellitus (DM) is a global health challenge (Hossain et al., 2024), with type 2 diabetes mellitus (T2DM) representing a metabolic disorder characterized by hyperglycemia, insulin resistance, and impaired insulin secretion (Lima et al., 2022). In 2021, ∼537 million people were living with diabetes, a figure expected to rise to 643 million by 2030 and 783 million by 2045 (IDF, 2015). Global trends in T2DM-related complications and mortality, highlighting the rising rates in lowand middle-income countries due to factors like obesity and poor lifestyle (Ali et al., 2022). The worldwide T2DM burden has risen dramatically since 1990, with all-age deaths increasing by 203.9%(from 0.238 to 0.7237 million) and disability-adjusted life years (DALYs) surging by 276.7%(from 10.4 to 39.3 million). Projections indicate a continued upward trend, with deaths expected to reach 1.2967 million and DALYs to reach 85.5 million by 2045 (Huang et al., 2025). The pathogenesis of DM involves multiple interconnected factors, including chronic hyperglycemia, dyslipidemia (Dagnew et al., 2021; Maldonado et al., 2025), and marked disturbances in the oxidant-antioxidant homeostasis (Iacobini et al., 202

FAQs

What was the main aim of the study?

To assess how coriander seed powder supplementation affects serum lipid profiles, glycemic indices, and oxidative stress biomarkers in patients with type 2 diabetes mellitus.

How was the study designed and what doses were used?

A randomized, double-blind, placebo-controlled trial with 40 participants. The intervention group received coriander seed powder 1,000 mg/day and the placebo group received placebo 1,000 mg/day for 6 weeks.

Which outcomes improved after coriander seed supplementation?

FBS, serum insulin, HOMA-IR, total cholesterol, triglycerides, LDL-C, and MDA decreased, while total antioxidant capacity increased significantly after treatment.

Sep 29, 2026

Uploaded by ahduag