Effect of Pulmonary Rehabilitation in Patients with Post-Tuberculosis Sequelae with Functional Limitation

Q: What was the study purpose regarding pulmonary rehabilitation in post-tuberculosis sequelae?

To evaluate whether pulmonary rehabilitation has similar benefits in patients with post-tuberculosis sequelae with functional limitation and whether two morphological variants respond similarly.

Q: How were participants assessed before and after pulmonary rehabilitation?

Baseline health assessment across different health domains was performed at enrollment, then repeated immediately after completing the rehabilitation program at 6 weeks.

Q: Which outcomes improved after pulmonary rehabilitation?

Dyspnea improved, 6MWD increased, SGRQ symptom/activity/impact/total scores decreased, and DASS stress, anxiety, and depression scores declined.

Q: Did bronchiectasis-predominant and fibrosis-predominant groups respond differently to PR?

No. Intergroup comparison indicated both morphological groups responded similarly to pulmonary rehabilitation.

Oct 6, 2026

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Background: Pulmonary rehabilitation (PR) may improve dyspnea, functional limitation, and quality of life in chronic respiratory disease, but its effects in patients with post-tuberculosis sequelae and in different morphological variants are unclear. Methods: Adult patients with post-tuberculosis sequelae with functional limitation (mMRC grade 1 or more) were recruited over two years, assessed at baseline across health domains, and reassessed immediately after a 6-week PR program. Results: 26 completed PR; dyspnea improved, exercise capacity increased, SGRQ scores decreased, and DASS stress/anxiety/depression reduced. Intergroup comparison showed similar responses in bronchiectasis-predominant and fibrosis-predominant groups. Conclusion: PR significantly improved dyspnea, quality of life, and mental health indices; functional capacity change was not statistically significant.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages7

Reading Time18 min

AccessFree to download

Introduction

Post-TB sequelae and need for rehabilitation

Methods

Study design and patient assessment

Results

Dyspnea, exercise capacity, SGRQ, and DASS outcomes

Intergroup comparison by morphological variants

Conclusion

indian journal of tuberculosis xxx (xxxx ) xxx Available online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com) ScienceDirect journal homepage: [http://www.journals. elsevier. com/](http://www.journals. elsevier. com/)[ ](http://www.journals. elsevier. com/)indian-journal-of-tuberculosis/ | Original article
Effect of pulmonary rehabilitation in patients with post-tuberculosis sequelae with functional limitation
Aqeel Hussain a, Alkesh Kumar Khurana a, *, Abhishek Goyal a, S.Y. Kothari b, Raj Krishnan Soman a, Sai Tej a, Abhijit Pakhare c
a Pulmonary, Critical Care & Sleep Medicine, AIIMS Bhopal, India b Physical Medicine & Rehabilitation, AIIMS Bhopal, India c Community and Family Medicine, AIIMS Bhopal, India | | | | --- | --- | --- | | a r t i c l e i n f o | | a b s t r a c t | | Article history:
Received 30 October 2022 Received in revised form 23 March 2023
Accepted 10 April 2023
Available online xxx | | Background: Pulmonary rehabilitation improves dyspnea, functional limitation and quality of life in patients with chronic respiratory disease especially Chronic obstructive pulmonary disease (COPD) . Whether Pulmonary rehabilitation (PR) will have similar effect inpatients with post-tuberculosis sequelae or not and whether the two morphological variants will respond similarly or not was the purpose of our study.
Methods: Adult patients fulﬁlling the inclusion criteria of a diagnosis of post-tuberculosis sequelae with functional limitation (modiﬁed medical research council [mMRC] grade 1 or more) were recruited over a period of two years. A baseline health assessment in the different domains of health was done at the beginning and repeated just after the completion of the rehabilitation program at 6 weeks.
Results: 26 patients completed the PR protocol of our study. Dyspnea improved from an mMRC grade of 1.5 to 0.7 post-PR (p < 0.001) . 6MWD increased by 34 meters from a baseline value of 408.6 meters to 442.7 meters post-PR. (p-value 0.3) St. George's Respiratory Questionnaire (SGRQ) symptom score decreased by 13 points, SGRQ activity score decreased by 18 points, SGRQ impact score decreased by 18 and SGRQ total score decreased by 17 points with p-values of 0.037, 0.002, 0.004 and 0.002 for SGRQ symptom score, SGRQ activity score, SGRQ impact score, SGRQ total score respectively. Depression Anxiety Stress Scale (DASS) Stress score decreased by 6.7, DASS Anxiety score decreased by 6.6, and DASS Depression score decreased by 5.5 points. Intergroup comparison revealed both bronchiectasis predominant group and ﬁbrosis predominant group responded similarly to PR.
Conclusion: PR improved parameters assessing dyspnea, quality of life and mental health indices signiﬁcantly. Improvement in functional capacity was not statically signiﬁcant. Both the morphological variants responded similarly to the PR.
© 2023 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved. | | Keywords: Dyspnea Bronchiectasis Fibrosis Quality of life | | | * Corresponding author. E-mail addresses: [aqeelturabi09@gmail.com](aqeelturabi09@gmail.com) (A. Hussain), [alkesh.pulmed@aiimsbhopal.edu.in](alkesh.pulmed@aiimsbhopal.edu.in) (A.K. Khurana), abhishek.pulmed@ [aiimsbhopal.edu.ins](aiimsbhopal.edu.ins) (A. Goyal), [shashank.pmr@aiimsbhopal.edu.in](shashank.pmr@aiimsbhopal.edu.in) (S.Y. Kothari), [rksut1688@gmail.com](rksut1688@gmail.com) (R.K. Soman), psaitej@gmail. com (S. Tej), [Abhijit.cfm@aiimsbhopal.edu.in](Abhijit.cfm@aiimsbhopal.edu.in) (A. Pakhare). [https://doi.org/10.1016/j.ijtb.2023.04.012](https://doi.org/10.1016/j.ijtb.2023.04.012) 0019-5707/© 2023 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved. Please cite this article as: Hussain A et al., Effect of pulmonary rehabilitation in patients with post-tuberculosis sequelae with functional limitation, Indian Journal of Tuberculosis, [https://doi.o

FAQs

What was the study purpose regarding pulmonary rehabilitation in post-tuberculosis sequelae?

To evaluate whether pulmonary rehabilitation has similar benefits in patients with post-tuberculosis sequelae with functional limitation and whether two morphological variants respond similarly.

How were participants assessed before and after pulmonary rehabilitation?

Baseline health assessment across different health domains was performed at enrollment, then repeated immediately after completing the rehabilitation program at 6 weeks.

Which outcomes improved after pulmonary rehabilitation?

Dyspnea improved, 6MWD increased, SGRQ symptom/activity/impact/total scores decreased, and DASS stress, anxiety, and depression scores declined.

Did bronchiectasis-predominant and fibrosis-predominant groups respond differently to PR?

No. Intergroup comparison indicated both morphological groups responded similarly to pulmonary rehabilitation.

Oct 6, 2026

Uploaded by Eliana