E-POSTERS - EP-001 - Exposure to metal mixtures and neurodevelopment outcomes in 4-5-year-old children living in Spain

Sep 15, 2026

Uploaded by William

Exposure to multiple toxic metals/metalloids and essential elements occurs simultaneously in real-life settings, producing potential additive, synergistic, or antagonistic health effects. Early life represents a vulnerable window for metal exposure with consequences that may persist across the lifespan. This study in Spain examines how metal mixture exposure relates to neurodevelopment at age 4, using urine-based measurements, principal component analysis to derive latent mixtures, and regression models adjusted for confounding factors.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages1268

Reading Time53 h 15 min

AccessFree to download

EP-001 Neurologic and mental health outcomes

Exposure to metal mixtures and neurodevelopment outcomes in 4-5-year-old children living in Spain

EP-002 Exposures

Pro-vegetarian dietary patterns and metal exposure in Spanish children of 4-5 years

E-POSTERS EP-001[Neurologic and mental health outcomes » Neurodevelopmental outcomes] Exposure to metal mixtures and neurodevelopment outcomes in 4-5-year-old children living in Spain N. Jimenez Redondo 1, S. Díaz Coto 2, P. Martinez Camblor3, M. Guxens4, M. Vrijheid4, A. Andiarena5, A. Irizar5, I. Riaño Galan6, A. Fernández Somoano 10, S. Llop7, M. Lozano7, M. R. Karagas2, J. Vioque9, M. Carey8, A. Meharg8, C. Meharg8, K. Ralphs8, C. Mccreanor8, E. Sendra 1, A. J. Signes Pastor9 1Centro de Investigación e Innovación Agroalimentaria y Agroambiental CIAGRO. Universidad Miguel Hernández de Elche.Ctra Beniel KM 3,2 03312 Orihuela (Alicante) . 2 Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States. 3 Biomedical Data Science Department, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States. 4ISGlobal-Instituto de Salud Global de Barcelona-Campus MAR, Parc de Recerca Biomèdica de Barcelona (PRBB), Barcelona, Spain. 5 Health Research Institute, Biodonostia, Donostia-San Sebastian, Spain. 6Servicio de Pediatría. Endocrinología pediátrica. HUCA. Roma Avenue s/n. 33001, Oviedo. Asturias, Spain. University Institute of Oncology of the Principality of Asturias (IUOPA)– Department of Medicine, University of Oviedo. Julián Clavería Street s/n. 33006, Oviedo. Asturias. Spain. Institute of Health Research of the Principality of Asturias (ISPA) . Roma Avenue s/n. 33001, Oviedo. Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. 7 Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIOPublic Health, Valencia, Spain. 8Institute for Global Food Security, Queen’s University Belfast, School of Biological Sciences Building, 19 Chlorine Gardens, Belfast, Northern Ireland, BT9 5DL. 9 Unidad de Epidemiología de la Nutrición. Universidad Miguel Hernández, Alicante, Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Spain. 10 University Institute of Oncology of the Principality of Asturias (IUOPA)– Department of Medicine, University of Oviedo. Julián Clavería Street s/n. 33006, Oviedo. Asturias. Spain. Institute of Health Research of the Principality of Asturias (ISPA) . Roma Avenue s/n. 33001, Oviedo. Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. BACKGROUND AND AIM:Humans are exposed to toxic metals/metalloids and essential elements (hereafter,“metals”) simultaneously in real-life scenarios with potential additive, synergistic or antagonistic effects. Early life is a vulnerable window for metal exposure, with potential adverse health effects that may last throughout the life course. This study aims to explore the association between metal mixture exposures and the neurodevelopment of children in Spain. METHOD:The study population (n = 962) belonged to the INMA Project. A standardised version of the McCarthy Scales of Children's Ability was used to assess 4-year-old children's neurodevelopment. The concentrations of As species, Co, Cu, Mo, Pb, Se and Zn were measured in spot urine samples adjusted for urine dilution. Principal component analysis was performed as a dimension reduction technique to identify latent metal mixtures. The association between the metal mixtures and children's neurodevelopment function scores was explored using multiple linear regression adjusted for confounding factors. RESULTS:Four principal components or metal mixtures were identified with a cumulative explained variance of 69% . The first component comprised the essential elements Cu, Se, and Zn, as well as the toxic metal Pb, and was linked to a decreased performance in global verbal, executive, verbal executive, and working memory function scores. The second component, compri

FAQs

What question does the EP-001 study address?

It investigates whether metal mixture exposures are associated with neurodevelopment in 4-5-year-old children living in Spain.

How were metal mixtures identified in EP-001?

Concentrations of multiple metal(loid) species were measured in spot urine, and principal component analysis was used to identify latent metal mixtures.

What neurodevelopment outcomes were linked to specific mixtures?

Different components were associated with distinct scores, including verbal, executive, working memory, motor, gross motor, and fine motor functions.

Sep 15, 2026

Uploaded by William