Dermatology Test Bank - Mini-Osce edition

Sep 20, 2026

Uploaded by Marry

Dermatology Test Bank Mini-Osce edition by Laith Sami focuses on psoriasis and psoriatic nail dystrophy, combining image-based question sets with answers and concise explanations. The material covers classic clinical descriptions of psoriatic plaques, likely triggers and genetics, nail changes such as onycholysis and pitting, and related histopathologic findings including acanthosis and parakeratosis. It also addresses systemic and biological treatment options, inheritance risk estimates, and links to psoriatic arthropathy and psoriatic arthritis presentations.

LanguageEnglish

CategoryExam

FormatPDF

Pages152

Reading Time6 h 23 min

AccessFree to download

Psoriasis Mini-Osce Questions

Q1: Clinical description, cause, and treatment

Q2: Nail changes and diagnosis

Q3: Histopathology and key pathogenesis steps

Q4: Inheritance risk and systemic treatments

Q5: Psoriatic arthritis diagnosis and supporting findings

Dermatology Test Bank Laith Sami Dermatology Test Bank Mini-Osce edition Laith Sami Psoriasis Q1) Look at this picture carefully, then answer the following questions? A) Describe? B) Most likely cause? C) Most appropriate Tx for this case? Answers: A) Well-demarcated, erythematous plaques with silver-white scaling. B) Psoriasis C) Phototherapy EXPLANATION: - Psoriasis: Psoriasis is now considered to be a genetically determined inflammatory systemic autoimmune disease. Characterized by plaques of diseased skin often at sites of minor trauma (elbows/knees), which occur next to areas of clear ‘normal’ skin. ○ well-demarcated and are erythematous with Silver-white surface scale. ● Associated with seronegative arthritis, type 2 diabetes, cardiovascular disease. The treatment ladder starts with avoidance of known exacerbating factors (smoking, alcohol), topical therapy, then Ultraviolet treatment (phototherapy and photochemotherapy) and finally systemic medication (tablet, S/C, IV) . Q2) Look at this picture carefully, then answer the following questions? A) What is the name of this condition? B) Most likely diagnosis? C) Mention other 3 nail changes can be seen with this disease? Answers: A) onycholysis B) Psoriasis C) Subungual hyperkeratosis / nail Pitting / Beau’s lines / Splinter hemorrhages EXPLANATION: - Psoriatic nail dystrophy: onycholysis, subungual hyperkeratosis, pitting, Beau’s lines (transverse lines, groove), splinter hemorrhages (longitudinal black lines) 1-onycholysis (lifting of the nail plate off the nail bed) due to abnormal cell adhesion; this usually manifests as a white or salmon patch on the nail plate 2-subungal hyperkeratosis (accumulation of chalky looking material under the nail) due to excessive proliferation of the nail bed that can ultimately lead toonycholysis 3-pitting (very small depressions in the nail plate) which result from parakeratotic (nucleated) cells being lost from the nail surface 4-Beau's lines (transverse lines on the nail plate) due to intermittent inflammation of the nail bed, leading to transient arrest in nail growth 5-splinter hemorrhages (which clinically look like minute longitudinal black lines) due to leakage of blood from dilated tortuous capillaries Q3) What is the histopathology for this disease? Answer: -Acanthosis, parakeratosis EXPLANATION: - Genetic predisposition + Precipitating factors “Stress, infection, local trauma Alcohol, drugs, childbirth.” ○ Hyperkeratosis “increased thickness + Thick keratin scale”, parakeratosis” keratocytes retain their nuclei”, poorly adherent and easily scraped off keratocytes (‘Auspitz sign’) ○ Vasodilation, angiogenesis → Inflammation → swelling (oedema) anderythema ○ sterile pustules “accumulation of inflammatory cells” → in palmo-plantarpustulosis, Look at this following picture: Acanthosis: Think of acanthosis as the VIP section of the epidermis. Thesquamous cell layer—the one responsible for your skin’s strength and resilience—decides to bulk up. It’s like doing extra reps at the skin gym. Acanthosis often shows up in conditions like psoriasis, where the skin cells are flexing their rete ridges (those little finger-like projections) like they’re ina bodybuilding competition. Q4) Look at this picture carefully, then answer the following questions? A) Describe? B) What’s the likelihood that her child would affect by this condition? C)Name 3 systemic Treatment? Answers: A) Well-demarcated, erythematous plaques with silver-white scaling. B) 1 parent:16%, 2parent:50% C) methotrexate, cyclosporine, biologic agents: infliximab EXPLANATION: - Systemic treatment ○ Indications → unstable inflamed psoriasis, widespread disease that have failed to respond to topical/phototherapy, psoriatic arthropathy. ○ first-line systemic → Acitretin ,Cyclosporin A, Methotrexate ○ 2nd line → Mycophenolate mofetil (MMF), hydroxyurea, azathiop

FAQs

What are the characteristic skin findings described for psoriasis in this test bank?

Well-demarcated, erythematous plaques with silver-white scaling are described as the classic appearance.

Which nail changes are associated with psoriatic nail dystrophy?

Onycholysis, subungual hyperkeratosis, nail pitting, Beau’s lines, and splinter hemorrhages are listed as associated changes.

What systemic or biological treatments are mentioned for psoriasis?

Systemic options include methotrexate, cyclosporine, and biological agents such as infliximab (anti-TNF), with additional systemic agents and a treatment ladder also provided.

Sep 20, 2026

Uploaded by Marry