Deleted in lymphocytic leukemia 2 (DLEU2) - a possible biomarker that holds promise for future diagnosis and treatment of cancer

Sep 24, 2026

Deleted in lymphocytic leukemia 2 (DLEU2) long non-coding RNA has become a major focus in oncology for understanding tumor occurrence and progression. Evidence indicates that lncRNA-DLEU2 can drive abnormal gene or protein expression through downstream targets, and that many DLEU2-associated lncRNAs function as oncogenes linked to proliferation, migration, invasion, and apoptosis. The review integrates DLEU2 expression, biological functions, molecular mechanisms, and evaluates DLEU2 as a diagnostic and prognostic marker, supporting its use as a biomarker and therapeutic target for cancer management.

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CategoryHealthcare

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Introduction

Clinical and Translational Oncology (2023) 25:2772–2782 [https://doi.org/10.1007/s12094-023-03149-x](https://doi.org/10.1007/s12094-023-03149-x) Deleted in lymphocytic leukemia 2 (DLEU2): a possible biomarker that holds promise for future diagnosis and treatment of cancer Xue Qu1 · Yu‑xia Cao2 · Yuan‑xin Xing3 · Qi Liu4 · Huan‑jie Li5 · Wei‑hua Yang2 · Ban‑qin Wang6 · Shu‑yi Han2 · Yun‑shan Wang2 Received: 7 December 2022 / Accepted: 4 March 2023 / Published online: 24 April 2023 © The Author(s) 2023 Abstract The mechanism of deleted in lymphocytic leukemia 2 (DLEU2)-long non-coding RNA in tumors has become a major point of interest in recent research related to the occurrence and development of a variety of tumors. Recent studies have shown that the long non-coding RNA DLEU2 (lncRNA-DLEU2) can cause abnormal gene or protein expression by acting on downstream targets in cancers. At present, most lncRNA-DLEU2 play the role of oncogenes in different tumors, which are mostly associated with tumor characteristics, such as proliferation, migration, invasion, and apoptosis. The data thus far show that because lncRNA-DLEU2 plays an important role in most tumors, targeting abnormal lncRNA-DLEU2 may be an effective treatment strategy for early diagnosis and improving the prognosis of patients. In this review, we integrated lncRNA-DLEU2 expression in tumors, its biological functions, molecular mechanisms, and the utility of DLEU2 as an effective diagnostic and prognostic marker of tumors. This study aimed to provide a potential direction for the diagnosis, prognosis, and treatment of tumors using lncRNA-DLEU2 as a biomarker and therapeutic target. Keywords lncRNA-DLEU2 · Cancer · Biomarker · Molecular mechanisms · Functions Abbreviations DLEU2 Deleted in lymphocytic leukemia 2 lncRNAs Long non-coding RNAs Xue Qu and Yu-xia Cao contributed equally to this work. * Ban-qin Wang [3052@sdhospital.com.cn](3052@sdhospital.com.cn) * Shu-yi Han [hanshuyi2016@126.com](hanshuyi2016@126.com) 1 Shandong First Medical University, No. 6699, Qingdao Road, Huaiyin District, Jinan 250117, Shandong, China 2 Medical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan 250013, Shandong, China 3 Research Center of Basic Medicine, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan 250013, Shandong, China 4 Shandong University, No. 44, Wenhua West Road, Jinan 250100, Shandong, China 5 Medical Integration and Practice Center, Shandong University, Jinan, China 6 Department of Blood Transfusion, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, China ncRNAs ceRNA CLL B-CLL AML PL BC EC ccRCC ESCA PC GC NSCLC TC PCa LC LSCC CC CRC TSA OS LAC HCC EMT Non-coding RNAs Competitive endogenous RNA Chronic lymphocytic leukemia B cell chronic lymphocytic leukemia Pediatric acute myeloid leukemia Pleomorphic liposarcoma Breast cancer Endometrial cancer Clear cell renal cell carcinoma Esophageal cancer Pancreatic cancer Gastric cancer Non-small cell lung cancer Thyroid cancer Prostate cancer Laryngeal cancer Laryngeal squamous cell carcinoma Cervical cancer Colorectal cancer Prostate-specific antigen Poor overall survival Lung adenocarcinoma Hepatocellular carcinoma Epithelial–mesenchymal transition cccDNA EV-DLEU2 NL CH mUICC AFP Covalently closed circular DNA Serum small extracellular vesicle-derived DLEU2 Normal health Chronic hepatitis Modified Union for International Cancer Control Alpha-fetoprotein Introduction Today, modern medicine and technology are developing rapidly. However, cancer remains one of the main causes of human death. The latest global cancer statistics show that 19.29 million new cancer cases and 9.96 million cancer deaths occ

FAQs

What is lncRNA-DLEU2 and why is it studied in tumors?

lncRNA-DLEU2 is a long non-coding RNA associated with tumor biology. Research focuses on how it may contribute to cancer development through changes in gene or protein expression.

How can lncRNA-DLEU2 influence cancer-related processes?

Studies summarized in the document indicate lncRNA-DLEU2 can regulate downstream targets, leading to abnormal gene/protein expression. It is commonly linked with tumor behaviors such as proliferation, migration, invasion, and apoptosis.

What roles does DLEU2 play according to the review?

The review integrates DLEU2 expression and mechanisms and evaluates DLEU2 as a diagnostic and prognostic marker. It also considers DLEU2 as a potential therapeutic target.

Sep 24, 2026

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