Decoding Fujian’s cervical HPV landscape - unmasking dominance of non-16/18 HR-HPV and tailoring prevention strategies at a large scale

Sep 21, 2026

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Persistent high-risk human papillomavirus (HR-HPV) drives cervical cancer and shows geographic variation: Europe/Americas report higher HPV16/18 rates, while Asia/Africa more often involve non-16/18 HR-HPV. This study in Fujian examines non-16/18 HR-HPV infections by estimating epidemiology and linking genotypes to cervical lesions for prevention design. Data include 101,621 women screened from 2013–2019 and 11,666 HPV-positive cases with histopathology.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages9

Reading Time23 min

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Background

Methods

Results

Conclusion

Introduction

TYPE Original Research PUBLISHED 06 June 2024 DOI 10.3389/fpubh.2024.1357073 OPEN ACCESS EDITED BY Kingston Rajiah, Ulster University, United Kingdom REVIEWED BY Arnaud John Kombe Kombe, University of Texas Southwestern Medical Center, United States Guy-Armel Bounda, China Pharmaceutical University, China *CORRESPONDENCE Xiangqin Zheng [Zhengxq1215@163.com](Zhengxq1215@163.com)[ ](Zhengxq1215@163.com)Huan Yi [yi.huan@fjmu.edu.cn](yi.huan@fjmu.edu.cn)[ ](yi.huan@fjmu.edu.cn)Jianrong Song [sjr0318@163.com](sjr0318@163.com) †These authors have contributed equally to this work RECEIVED 17 December 2023 ACCEPTED 16 May 2024 PUBLISHED 06 June 2024 CITATION Zhang Y, Li H, You Q, Chen Y, Zhao Z, Chen J, Su Y, Zheng X, Yi H and Song J (2024) Decoding Fujian’s cervical HPV landscape: unmasking dominance of non-16/18 HR-HPV and tailoring prevention strategies at a large scale. Front. Public Health 12:1357073 . doi: 10.3389/fpubh.2024.1357073 COPYRIGHT © 2024 Zhang, Li, You, Chen, Zhao, Chen, Su, Zheng, Yi and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Decoding Fujian’s cervical HPV landscape: unmasking dominance of non-16/18 HR-HPV and tailoring prevention strategies at a large scale Yulong Zhang 1†, Haibo Li 2†, Qianru You 1†, Yusha Chen3, Ziyan Zhao4, Jiancui Chen3, Yanzhao Su 1, Xiangqin Zheng 1*, Huan Yi 1*and Jianrong Song 1* 1 Department of Gynecology, Fujian Province Key Clinical Specialty for Gynecology, National Key Gynecology Clinical Specialty Building Institution, Fujian Maternity and Child Health Hospital College of Clinical Medical for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China, 2 Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China, 3Cervical Disease Diagnosis and Treatment Health Center, Fujian Maternity and Child Health Hospital College of Clinical Medical for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China, 4 Department of Integrative Biology, University of California-Berkeley, Berkeley, CA, United States Background: Persistent HR-HPV causes cervical cancer, exhibiting geographic variance. Europe/Americas have higher HPV16/18 rates, while Asia/Africa predominantly have non-16/18 HR-HPV. This study in Fujian, Asia, explores non-16/18 HR-HPV infections, assessing their epidemiology and cervical lesion association for targeted prevention. Methods: A total of 101,621 women undergoing HPV screening at a hospital in Fujian Province from 2013 to 2019 were included. HPV genotyping was performed. A subset of 11,666 HPV-positive women with available histopathology results were analyzed to characterize HPV genotype distribution across cervical diagnoses. Results: In 101,621 samples, 24.5% tested positive for HPV. Among these samples, 17.3% exhibited single infections, while 7. 2% showed evidence of multiple infections. The predominant non-16/18 high-risk HPV types identified were HPV 52, 58, 53, 51, and 81. Single HPV infections accounted for 64.1% of all HPVpositive cases, with 71 .4% of these being non-16/18 high-risk HPV infections. Agerelated variations were observed in 11,666 HPV-positive patients with pathological results. Cancer patients were older. In the cancer group, HPV52 (21 .8%) and HPV58 (18 .6%) were the predominant types, followed by HPV33, HPV31, and HPV53 . Compared to single HPV16/18 infection, non-16/18 HPV predominated in LSIL. Adj

FAQs

What was the main goal of this Fujian-based study on cervical HPV?

To characterize non-16/18 HR-HPV infections in Fujian by describing epidemiology and evaluating associations with cervical lesions to support targeted prevention.

How many women were included, and what time period did the screening cover?

A total of 101,621 women were included, undergoing HPV screening at a hospital in Fujian Province from 2013 to 2019.

Which HR-HPV types were identified as predominant non-16/18 types?

The predominant non-16/18 HR-HPV types identified were HPV 52, 58, 53, 51, and 81.

Sep 21, 2026

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