Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis

Sep 24, 2026

Uploaded by nayy☆

Glioblastoma multiforme (GBM) is a highly heterogenic, malignant brain tumour with a median survival of 15 months, and early identification of primary cases remains difficult. Coronin 1C (CORO1C) regulates actin rearrangement and cofilin dynamics, supporting neurite overgrowth and tumour-cell migration. Bioinformatic analyses quantify CORO1C expression in normal versus malignant brains at mRNA and protein levels. Elevated CORO1C in high-grade metastatic contexts, including GBM, indicates potential biomarker utility linked to poor outcomes, supported by 62 targeting microRNAs.

LanguageEnglish

CategoryHealthcare

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Pages18

Reading Time45 min

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Introduction

Epidemiology and Molecular Characteristics

non-coding RNA Article Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis Denis Mustafov 1,2, Emmanouil Karteris 2 and Maria Braoudaki 1, * Citation: Mustafov, D.; Karteris, E.; Braoudaki, M. Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis. Non-Coding RNA 2023, 9, 4. [https://](https://)[ ](https://)[doi.org/10.3390/ncrna9010004](doi.org/10.3390/ncrna9010004) Academic Editors: Hsiuying Wang and Y-h. Taguchi Received: 2 December 2022 Revised: 28 December 2022 Accepted: 2 January 2023 Published: 4 January 2023 Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 School of Life and Medical Sciences, University of Hertfordshire, Hatﬁeld AL10 9AB, UK 2 College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK * [Correspondence: m.braoudaki@herts.ac.uk](Correspondence: m.braoudaki@herts.ac.uk) Abstract: Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identiﬁcation of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key player in actin rearrangement and coﬁlin dynamics, as well as enhancing the processes of neurite overgrowth and migration of brain tumour cells. Different bioinformatic databases were accessed to measure CORO1C expression at the mRNA and protein level in normal and malignant brains. CORO1C expression was observed in brain regions which have retained high synaptic plasticity and myelination properties. CORO1C was also expressed mainly within the hippocampus formation, including the Cornu Ammonis (CA) ﬁelds: CA1–CA4 . Higher expression was also noticed in paediatric GBM in comparison to their adult counterparts. Pediatric cell populations were observed to have an increased log2 expression of CORO1C. Furthermore, 62 miRNAs were found to target the CORO1C gene. Of these, hsa-miR-34a-5p, hsa-miR-512-3p, hsa-miR-136-5p, hsa-miR-206, hsa-miR-128-3p, and hsa-miR-21-5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. The elevated expression of CORO1Cin high grade metastatic brain malignancies, including GBM, suggests that this protein could have a clinical utility as a biomarker linked to an unfavorable outcome. Keywords: CORO1C; mRNA; microRNA expression; brain; cancer; glioblastoma; pediatric; adult 1. Introduction 1.1. Epidemiology and Molecular Characteristics Presented with a 5-year survival rate of 5.6%, glioblastoma multiforme (GBM) remains one of the most aggressive and deadliest glial malignancies amongst adults [1] . The median onset of GBM is 64 years; however, the malignancy can occur at any age indiscriminatory [2] . GBM accounts for nearly 3350 newly diagnosed cases in the UK annually with an overall survival rate between 6–17 months. Proclaimed as an incurable brain tumour due to its inﬁltrative nature, complete surgical resection of the tumour burden is almost impossible, and thus inevitable progression of residual inﬁltrates enhance relapse and reoccurrence of the malignancy [3] . Postoperative radiotherapy and adjuvant chemotherapy with temozolomide are subsequently prescribed post tumour resection. Paediatric glioblastomas (pGBM) possess distinctive molecular characteristics, which distinguish them from their adult counterparts. pGBM is a rare event accounting for 3–7% of all primary central nervous system (CNS) tumours in children [4] . The estimated median overall survival rate for paediatric GBM is 10.5 months, with children over 10 years of age being impacted more, d

FAQs

Why is CORO1C important in glioblastoma biology?

CORO1C is described as a key regulator of actin rearrangement and cofilin dynamics, promoting neurite overgrowth and brain tumour cell migration.

How was CORO1C expression compared across different brain states?

Different bioinformatic databases were used to measure CORO1C expression at the mRNA and protein levels in normal and malignant brains.

What evidence suggests CORO1C may be useful clinically?

The document reports elevated CORO1C expression in high-grade metastatic brain malignancies, including GBM, and links the protein’s expression pattern to an unfavorable outcome, suggesting biomarker potential.

Sep 24, 2026

Uploaded by nayy☆