Deciphering Glioblastoma - Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas

Sep 24, 2026

Uploaded by Riley

Gliomas represent a diverse and complex set of central nervous system tumors with varied prognostic outcomes and treatment responses. This literature review analyzes gliomas with a primary focus on glioblastoma, covering classification and epidemiology within the CNS tumor spectrum. It evaluates the immunological context, key discoveries in tumor behavior, recent treatment-response advances, and cellular signaling pathways. It also integrates transcriptomic findings, gene-expression variability, prognostic and therapeutic implications, and the contribution of epigenetic alterations to tumor evolution and potential therapeutic progress.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages42

Reading Time1 h 46 min

AccessFree to download

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Review Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas Razvan Onciul 1,2,†, Felix-Mircea Brehar 1,3,*, Corneliu Toader 1,4,†, Razvan-Adrian Covache-Busuioc 1, Luca-Andrei Glavan 1, Bogdan-Gabriel Bratu 1, Horia Petre Costin 1, David-Ioan Dumitrascu 1, Matei Serban 1 and Alexandru Vlad Ciurea 1,5 Citation: Onciul, R.; Brehar, F.-M.; Toader, C.; Covache-Busuioc, R.-A.; Glavan, L.-A.; Bratu, B.-G.; Costin, H.P.; Dumitrascu, D.-I.; Serban, M.; Ciurea, A.V. Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas. Curr. Issues Mol. Biol. 2024, 46, 2402–2443. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/cimb46030153](10.3390/cimb46030153) Academic Editor: Joana Márquez Received: 24 January 2024 Revised: 6 March 2024 Accepted: 9 March 2024 Published: 13 March 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 Department of Neurosurgery,“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; [razvan.onciul@drd.umfcd.ro](razvan.onciul@drd.umfcd.ro) (R.O.); [corneliu.toader@umfcd.ro](corneliu.toader@umfcd.ro) (C.T.); [razvan-adrian.covache-busuioc0720@stud.umfcd.ro](razvan-adrian.covache-busuioc0720@stud.umfcd.ro) (R.-A.C.-B.); [luca-andrei.glavan0720@stud.umfcd.ro](luca-andrei.glavan0720@stud.umfcd.ro) (L.-A.G.); [bogdan.bratu@stud.umfcd.ro](bogdan.bratu@stud.umfcd.ro) (B.-G.B.); [horia-petre.costin0720@stud.umfcd.ro](horia-petre.costin0720@stud.umfcd.ro) (H.P.C.); [david-ioan.dumitrascu0720@stud.umfcd.ro](david-ioan.dumitrascu0720@stud.umfcd.ro) (D.-I.D.); [matei.serban2021@stud.umfcd.ro](matei.serban2021@stud.umfcd.ro) (M.S.); [prof.avciurea@gmail.com](prof.avciurea@gmail.com) (A.V.C.) 2 Neurosurgery Department, Emergency University Hospital, 050098 Bucharest, Romania 3 Department of Neurosurgery, Clinical Emergency Hospital “Bagdasar-Arseni”, 041915 Bucharest, Romania 4 Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 077160 Bucharest, Romania 5 Neurosurgery Department, Sanador Clinical Hospital, 010991 Bucharest, Romania * Correspondence: [felix.brehar@umfcd.ro](felix.brehar@umfcd.ro) † These authors contributed equally to this work. Abstract: Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies. Moreover, we accentuate critical developments in understanding tumor behavior, focusing on recent research breakthroughs in treatment responsesand the elucidation of cellular signaling pathways. Analyzing the most novel transcriptomic studies, we investigate the variations in gene expression patterns in glioma cells, assessing the prognostic and therapeutic implications of these genetic alterations. Furthermore, the role of epigenetic modifications in the pathogenesis of gliomas is underscored, suggesting that such changes are fundamental to tumor evolution and possible therapeutic advancements. In the end, this comparative oncological analysis situates GBM within the wider context of neoplasms, delineating both distinc

FAQs

What is the focus of the review on glioblastoma?

The review emphasizes glioblastoma within the broader glioma landscape, covering its classification, epidemiology, immunological context, and recent advances in therapeutic understanding.

How does the review describe progression in gliomas?

It outlines glioma progression as developmental stages, including early transformation, invasion capability, increased proliferation, disrupted cell-cycle control, enhanced angiogenesis, and clonal evolution that drives heterogeneity.

What molecular research areas are highlighted in the review?

The review highlights transcriptomic studies of gene-expression patterns and the role of epigenetic modifications in glioma pathogenesis, linking these changes to prognosis and therapeutic potential.

Sep 24, 2026

Uploaded by Riley