Correlation of Biochemical Secretion and Imaging Parameters on [18F]-SiTATE-PET/CT in Pheochromocytoma and Paraganglioma

Sep 2, 2026

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SSTR-targeted [18F]-SiTATE-PET/CT is evaluated for diagnosing pheochromocytoma and paraganglioma by relating imaging readouts to tumor marker levels and secretory activity. Patients with histologically confirmed PPGL underwent [18F]-SiTATE-PET/CT between 2020 and 2024 and provided plasma and 24-hour urine hormonal measurements within 100 days. Metabolic tumor volume used SUVmean=5.0, with total lesion uptake derived as SUVmean×MTV. Moderate correlations were observed between TLU/MTV and urinary dopamine, norepinephrine, serum chromogranin-A, and plasma normetanephrine and 3-methoxytyramine.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages36

Reading Time1 h 31 min

AccessFree to download

Introduction

Methods

Results

Conclusion

| 138 | | --- | | Correlation of biochemical secretion and imaging parameters on [18F] -SiTATE-PET/CT in pheochromocytoma and paraganglioma
Meike Onkes1, Paul Dahlmann1, Christine Schmid-Tannwald2,
Junia Schweizer3, Isabel St¨ufchen3, Lena Unterrainer1, Matthias Brendel1, Matthias Kroiss3, Martin Bidlingmaier3 & Friederike V¨olter3
1Department of Nuclear Medicine, LMU Klinik Munich; 2Department of Radiology, LMU Klinik Munich; 3Department of Endocrinology, LMU Klinik Munich
Introduction
Somatostatin receptor (SSTR)-targeted PET/CT is widely used for diagnosing and monitoring pheochromocytoma and paraganglioma (PPGLs) . This study aims to evaluate the potential of the novel SSTR-targeted tracer [18F]-SiTATE in diagnosing PPGLs by comparing imaging parameters with tumor marker levels and secretory activity in a small cohort of patients diagnosed with PPGL. Methods
All patients with histologically conﬁrmed PPGL who presented for [18F] -SiTATE-PET/CT at LMU Klinikum between October 2020 and February 2024, along with hormonal laboratory analysis of both plasma and 24-hour urine samples within up to 100 days, were included. Metabolic tumor volume (MTV) was assessed using a threshold of mean standard uptake value (SUVmean) of 5.0 . Total lesion uptake (TLU) was assessed as SUVmean ! MTV. Correlation was tested using Spearman’s rank correlation test.
Results
Thirty-four out of 39 patients (median age: 55, range: 5-83) were included in this study, with 5 patients with cervical PGL excluded. Twenty-one patients had metastatic disease. There was a moderate correlation between TLU and MTV and urinary dopamine (r Z 0.50-0.51, P ! 0.05) as well as norepinephrine (r Z 0.50- 0.54, P ! 0.05) . TLU and MTV also moderately correlated with serum chromogranin-A levels (r Z 0.60, P ! 0.01) . Additionally, a moderate correlation was found between TLU and MTV with plasma normetanephrine and 3-methoxytyramine (r Z 0.52-0.56, P ! 0.01) .
Conclusion
MTV and TLU measured with [18F]-SiTATE-PET/CT correlate well with serum chromogranin-A and speciﬁc catecholamine pathway biomarkers in urine and plasma, reﬂecting metabolic tumor activity. Despite the limitations of the relatively small cohort, our results suggest that TLU in [18F]-SiTATE-PET/CT could be used as an imaging biomarker for monitoring disease progression and secretory activity in patients with PPGL.
DOI: 10.1530/endoabs.102.138 | | 80 | | 4 | | --- | | Androgen secreting adrenocortical carcinoma
Tamara Dojcinovic1,2, Jelena Malinovic Pancic1,2 & Aleksandra Markovic1,2
1Department of Endocrinology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina; 2School of Medicine, University of Banja Luka, Bosnia and Herzegovina
Introduction
Adrenocortical carcinoma (ACC) is a rare malignancy with estimated annual incidence of 0,7 to 2 cases per milion, and it is more commonly diagnosed in women. Being extremely agressive entity, survival median of four years is notsuprising. Hormone secreting ACC is found in 60% of patients diagnosed with disease, whereas isolated hyperandrogenism is found in 3-5% cases of adult patients.
Case presentation
We present the case of 63-year-old patient who was hospitalized in endocrinology department for functional testing of adrenal incidentaloma. She presented with abdominal pain and fatigue and malaise, clinically she was obese with signs of hyperandrogenemia i.e. marked hirsutism. In laboratory results we found increased values of DHEAS of 1073..1326,2 mg/dl and testosteron: 2,09 ng/ml, while ACTH, daily cortisol, renin, aldosteron and 24h urinary catecholamine values were in refferent range. The Chest CT revealed no abnormalities, while abdominal NMR detected expansive heterogeneous mass with smaller zones of necrosis sized 11 ! 9.4 ! 11.5 cm with suppression of the pancreas but without signs of inﬁltration of surrounding structures. Abdominal surgeon was consulted, patient was oper

FAQs

What was the main aim of the study using [18F]-SiTATE-PET/CT?

To evaluate whether the novel SSTR-targeted tracer [18F]-SiTATE can diagnose PPGLs by comparing imaging parameters with tumor marker levels and secretory activity.

How were MTV and TLU calculated in this research?

Metabolic tumor volume (MTV) was assessed using a threshold SUVmean of 5.0, and total lesion uptake (TLU) was calculated as SUVmean multiplied by MTV.

Which biomarkers showed correlations with TLU and MTV?

TLU and MTV correlated moderately with urinary dopamine and norepinephrine, serum chromogranin-A, and plasma normetanephrine and 3-methoxytyramine.

Sep 2, 2026

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