Correction to “Gallium Complex K6 Inhibits Colorectal Cancer by Increasing ROS Levels to Induce DNA Damage and Enhance Phosphatase and Tensin Homolog Activity”

Sep 29, 2026

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Correction note for a MedComm article reporting that a mistake was identified in the raw data during Figure 3B review. The authors state that the image data for SW620 cells treated with L-OHP (8 µM) or K6 (8 µM) for 2 h in Figure 3B were incorrect and have been replaced with the correct images. The revised result is presented, and the authors apologize while declaring the correction does not change description, interpretation, or conclusions.

LanguageEnglish

CategoryHealthcare

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Pages2

Reading Time5 min

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Correction Notice

Details of the Figure 3B Error and Replacement

Statement on Impact to Conclusions

Figure 3 Summary

MedComm CORRECTION Correction to “Gallium Complex K6 Inhibits Colorectal Cancer by Increasing ROS Levels to Induce DNA Damage and Enhance Phosphatase and Tensin Homolog Activity” Li W, Yang C, Cheng Z, et al.,“Gallium complex K6 inhibits colorectal cancer by increasing ROS levels to induce DNA damage and enhance phosphatase and tensin homolog activity.” MedComm. (2024);5:e665 . doi: 10.1002/mco2.665 In the process of checking the raw data [1], the authors noticed an inadvertent mistake occurring in Figure 3B that needed tobe corrected after the online publication of the article. In paragraph 3 of the “Results” section, the image data for SW620 cells following treatment with L-OHP (8 µM) orK6 (8 µM) for 2 h in Figure 3B was incorrect and has been replaced with the correct images. The corrected result is shown below. The authors apologize for this error and declare that this correction does not affect the description, interpretation, or conclusions. 1. Li W, Yang C, Cheng Z, et al.,“Gallium complex K6 inhibits colorectal cancer by increasing ROS levels to induce DNA damage and enhance phosphatase and tensin homolog activity.” MedComm (2020). 2024 Jul 24;5(8):e665. [https://doi.org/10.1002/mco2.665](https://doi.org/10.1002/mco2.665) . This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. MedComm, 2026; 7:e70527 [https://doi.org/10.1002/mco2.70527](https://doi.org/10.1002/mco2.70527) 1 of 2 FIGURE 3 K6 upregulated reactive oxygen species (ROS) levels to induce deoxyribonucleic acid (DNA) damage in SW480 and SW620 cell lines. (A) K6 upregulated ROS levels in SW480 and SW620 cells. The ROS levels of SW480 and SW620 cells after treatment with K6 (2, 4, and 8 µM) or oxaliplatin (L-OHP) (8 µM) for 6 h were assessed by flow cytometry. (B) K6 induced the rapid accumulation of γH2Ax in SW480 and SW620 cells. The γH2Ax accumulation levels in SW480 and SW620 cells after treatment with K6 (8 µM) or L-OHP (8 µM) for 1 and 2 h were assessed by immunofluorescence.(C) K6 upregulated the phosphorylation of DNA damage-related proteins in SW480 and SW620 cells. The phosphorylation levels of ATM, CHK1, CHK2, and H2Ax proteins in SW480 and SW620 cells after treatment with K6 (8 µM) or L-OHP (8 µM) for 1 and 2 h were detected by Western blotting (WB) .(D) N-acetyl-L-cysteine (NAC) antagonized K6-induced upregulation of γH2Ax protein levels. Following pretreatment of SW480 and SW620 cells with NAC (1 mM) for 12 h, cells were treated with K6 (8 µM) for 2 h, and γH2Ax protein levels were assessed by WB. (E) NAC inhibited the ability of K6 to downregulate the activity of SW480 and SW620 cells. SW480 and SW620 cells were treated with NAC (1 mM) or K6 (8 µM) alone or a combination of both for 48 h, and the cell viability was measured using sulforhodamine B (SRB) .

FAQs

What was corrected in the article?

The authors corrected the image data in Figure 3B for SW620 cells after treatment with L-OHP (8 µM) or K6 (8 µM) for 2 h.

How did the authors determine the correction was needed?

During checking of the raw data, the authors noticed an inadvertent mistake in Figure 3B after the article was published online.

Does the correction affect the study’s conclusions?

No. The authors declare that the correction does not affect the description, interpretation, or conclusions.

Sep 29, 2026

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