Correction - The association between antihypertensive treatment and serious adverse events by age and frailty - A cohort study - Corrections to the analyses, abstract, and outcomes

Sep 29, 2026

Uploaded by Jasmine

Correction to a PLOS Medicine cohort study examining the association between antihypertensive treatment and serious adverse events stratified by age and frailty. Authors report data-management omissions affecting fall-related outcomes, and re-run analyses. The notice updates wording in the Abstract (primary outcome definition and multiple hazard ratio estimates) and revises bullet points in the Author Summary. It also corrects several sentences across Methods/Outcomes and Results sections, including study population characteristics and hospitalization risk estimates.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages8

Reading Time20 min

AccessFree to download

Correction notice

Authors’ explanation of data and manuscript issues

Abstract corrections

Author Summary corrections

Methods/Outcomes corrections

Results corrections

OPEN ACCESS Citation: Sheppard JP, Koshiaris C, Stevens R, Lay-Flurrie S, Banerjee A, Bellows BK, et al.(2026) Correction: The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study. PLoS Med 23(1): e1004885. [https://doi.org/10.1371/](https://doi.org/10.1371/)[ ](https://doi.org/10.1371/)[journal.pmed.1004885](journal.pmed.1004885) [Published:](Published: January 5)[ January 5](Published: January 5) , 2026 Copyright: © 2026 Sheppard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CORRECTION Correction: The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study James P. Sheppard, Constantinos Koshiaris, Richard Stevens, Sarah Lay-Flurrie, Amitava Banerjee, Brandon K. Bellows, Andrew Clegg, F. D. Richard Hobbs, Rupert A. Payne, Subhashisa Swain, Juliet A. Usher-Smith, Richard J. McManus It has come to the attention of the authors that some outcomes, related to fall events, were not included in the original analysis dataset, due to an error during data management. This has now been corrected, and the analysis re-run resulting in the corrections listed below. Furthermore, the original published manuscript described outcomes as an event associated with hospitalisation or death. However, deaths that were not preceded by a hospitalisation, were not included in the analysis. Finally, Table 1 presents the number (%) of males in the cohort, not females, as described in the original published manuscript. In the Methods and findings subsection of the Abstract, there is an error in the fourth sentence of the paragraph. The correct sentence is: The primary outcome was hospitalisation within 10 years from falls. In the Methods and findings subsection of the Abstract, there is an error in the 10th sentence. The correct sentence is: Antihypertensives were associated with an increased risk of hospitalisation from falls (adjusted Hazard Ratio [aHR] 1. 10, 95% Confidence Interval 1.08–1. 12), hypotension (aHR 1.32, 95% CI 1.29–1.35), syncope (aHR 1.20, 95% CI 1.17–1.22), AKI (aHR 1.44, 95% CI 1.41–1.47), electrolyte abnormalities (aHR 1.45, 95% CI 1.43–1.48) and primary care attendance with gout (aHR 1.35, 95% CI 1.32–1.37) . In the Methods and findings subsection of the Abstract, there is an error in the 12th sentence. The correct sentence is: In older patients (80–89 years) and those with severe frailty, this absolute risk was increased, with 38 and 39 fall events per 10,000 patients treated per year (respectively) . In the What Did the Researchers Do and Find subsection of the Author Summary, there is an error in the third and fourth bullet. The correct bullets are: • In a total of 3,834,056 patients, blood pressure lowering treatment was associated with an increased risk of hospitalisation from falls, hypotension, syncope (but not fracture), acute kidney injury, electrolyte abnormalities and primary care consultations for gout. • These risks were much higher in older patients and those with frailty. For example, in those aged 40–49 years 913 patients would need to be treated for 5 years to PLOS Medicine | [https://doi.org/10.1371/journal.pmed.1004885](https://doi.org/10.1371/journal.pmed.1004885) January 5, 2026 1 / 8 cause a serious fall. However, for those aged 80–89 years, only 53 patients would need to be treated for 5 years to cause a serious fall. In the Outcomes subsection of the Methods, there is an error in the first, second and fourth sentences. The correct first sentence is: The primary outcome of this analysis was first hospitalisation with a primary diagnosis of a fall (defined according to ICD9 and ICD10 codes listed in S3 Table) . The correct second sentence is: Secondary outcomes were first hospit

FAQs

What caused the need for this correction?

An error during data management led to the omission of some fall-related outcomes from the original analysis dataset.

Which primary outcome definition was corrected in the Abstract?

The primary outcome was hospitalisation within 10 years from falls.

What impact did antihypertensives have according to the corrected Abstract sentence?

Antihypertensives were associated with increased risk of hospitalisation from falls and several related conditions, including hypotension, syncope, AKI, electrolyte abnormalities, and primary care attendance with gout.

Sep 29, 2026

Uploaded by Jasmine